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One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration

  • Retinal Disorders
  • Published:
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Abstract

Background

To evaluate the efficacy of combined photodynamic therapy (PDT) and intravitreal bevacizumab injection in eyes with a serous pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD).

Methods

Twenty-two eyes with a serous PED exceeding two disc areas associated with AMD with choroidal vascular abnormalities [choroidal neovascularization (n = 10), polypoidal choroidal vasculopathy (n = 9), and retinal angiomatous proliferation (n = 3)] received combined PDT and intravitreal bevacizumab, and were followed about every 6 weeks for more than 1 year. Additional treatments were given for residual or recurrent lesions. The main outcome measures were changes in the PED height measured by optical coherence tomography, and the best-corrected visual acuity.

Results

After one treatment, the PED resolved in 12 eyes (55%) and the PED decreased in ten eyes (45%). There was no recurrence in eight (36%) eyes; however, PED recurred in 14 eyes. At 1 year, the average PED height decreased to 413 microns from the baseline 751 microns (p < 0.001). Twenty eyes (91%) had improved or stabilized vision; two eyes had decreased vision due to a retinal pigment epithelial tear and subretinal hemorrhage.

Conclusions

Combined PDT and intravitreal bevacizumab may decrease the PED height and stabilize visual acuity at 1 year.

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Chiharu Shima, Fumi Gomi, Miki Sawa, Hirokazu Sakaguchi, Motokazu Tsujikawa & Yasuo Tano

Authors
  1. Chiharu Shima
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  2. Fumi Gomi
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  3. Miki Sawa
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  4. Hirokazu Sakaguchi
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  5. Motokazu Tsujikawa
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  6. Yasuo Tano
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Corresponding author

Correspondence to Fumi Gomi.

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The authors have no proprietary and financial interest in any aspect of this report.

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Shima, C., Gomi, F., Sawa, M. et al. One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 247, 899–906 (2009). https://doi.org/10.1007/s00417-009-1067-9

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  • DOI: https://doi.org/10.1007/s00417-009-1067-9

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