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The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis

Results of a double-blind, randomised, controlled trial

  • Rhinology
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

In a prospective, randomised, double-blinded controlled study, we compared the efficacy and safety of two different treatment options with the herbal medicines cineole and a combination of five different components for acute viral rhinosinusitis. One hundred and fifty patients with acute and viral rhinosinusitis (75 patients in each treatment group) were enrolled. The diagnosis rhinosinusitis was made according to a defined symptoms-sum-score which was based on rhinoscopic and clinical signs which are characteristic for rhinosinusitis. The primary endpoint was the amelioration of the symptoms-sum-score, which includes all relevant characteristics for rhinosinusitis as headache on bending, frontal headache, sensitivity of pressure points of trigeminal nerve, impairment of general condition, nasal obstruction, rhino-secretion, secretion quantity, secretion viscosity and fever in a treatment period of 7 days. The mean reduction of the symptoms-sum-score after 4 days was 6.7 (±3.4) and after 7 days 11.0 (±3.3) in the cineole group and 3.6 (±2.8) after 4 days and 8.0 (±3.0) after 7 days in the control group. The differences between both groups were clinically relevant and statistically significant after 4 and 7 days (P < 0.0001). This result is validated by the amelioration of the secondary endpoints headache on bending, frontal headache, sensitivity of pressure points of trigeminal nerve, impairment of general condition, nasal obstruction and rhino-secretion. These findings correlate with the statistically significant difference of the estimation of B-scan ultrasonography. It is safe to use both medications for 7 days in patients with acute viral rhinosinusitis. Treatment with cineole is clinically relevant and statistically significant, more effective in comparison to the alternative herbal preparation with five different components.

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References

  1. Evans KL (1994) Diagnosis and management of sinusitis. BMJ 309:1415–1422

    PubMed  CAS  Google Scholar 

  2. Lee KJ (ed) (1995) Essential otolaryngology. Head and neck surgery, 6th edn. Appleton & Lange, New York

  3. Dorow P (1989) What influence does cineole have on mucociliary clearance? Therapiewoche 39:2652

    Google Scholar 

  4. Juergens UR, Stöber M, Vetter H (1998) Steroid-like inhibition of monocyte arachidonic acid metabolism and IL-1β production by eucalyptole (1.8-cineole). Atemwegs Lungenerkrankungen 24:3–11

    CAS  Google Scholar 

  5. Kaspar P, Petro W, Swoboda M (1990) Influence of etheric oils on the activity of human cilia. Pneumologie 44:1062

    Google Scholar 

  6. Kaspar P, Repges R, Dethlefsen U, Petro W (1994) Comparison of secretolytics. Change of ciliary frequency and lungfunction after therapy with cineole and ambroxol. Atemwegs Lungen-krankheiten 20:605–614

    Google Scholar 

  7. Kehrl W, Sonnemann U, Dethlefsen U (2004) Therapy of acute nonpurulent rhinosinusitis with cineole: results of a double-blind, randomised, placebo-controlled trial. Laryngoscope 114:738–742

    Article  PubMed  Google Scholar 

  8. Neubauer N, Maerz RW (1994) Placebo-controlled, randomized double-blind clinical trial with Sinupret, sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1(3):177–181

    Google Scholar 

  9. Wei LJ, Lachin JM (1984) Two-sample asymptotically distribution-free tests for incomplete multivariate observations. J Am Stat Assoc 79:653–661

    Article  Google Scholar 

  10. Federspil P, Wulokow R, Zimmermann Th (1997) Efficacy of myrtol standardized in the therapy of acute sinusitis—results of a double blind, randomised, placebo-controlled multicentre trial. Laryngo-Rhino-Otol 76:23–27

    Article  CAS  Google Scholar 

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Correspondence to Stefan Tesche.

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This study was funded by a grant of Cassella-med, Cologne, Germany.

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Tesche, S., Metternich, F., Sonnemann, U. et al. The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Eur Arch Otorhinolaryngol 265, 1355–1359 (2008). https://doi.org/10.1007/s00405-008-0683-z

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  • DOI: https://doi.org/10.1007/s00405-008-0683-z

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