Abstract
Purpose
To evaluate morphology of lateral ventricles of ventriculomegaly/hydrocephaly fetuses using 3D-sonography by virtual organ computer-aided analysis (VOCAL) technique and magnetic resonance imaging (MRI) and verify morphologic patterns related to etiology.
Methods
Seventeen fetuses presenting with ventricular enlargement (atria > 10 mm) were evaluated. 3D datasets were acquired from a coronal reference plane and post-processed by the rotational imaging using VOCAL 30o. MRI study was analyzed in the three plans in all sequences. Morphologic aspects such as global shape, anterior, posterior and inferior horn characteristics, wall irregularities and deformities were analyzed and related to etiology factor.
Results
Twenty-nine percent of the cases were secondary to Arnold–Chiari syndrome and presented with global dilation of the three-horns. Cases related to aqueduct stenosis presented with ependymal rupture and wall irregularities in advanced cases. Corpus callosum agenesis cases presented with small ventricular volumes, thin shape, normal or slightly enlarged anterior and inferior horns with dilation restricted to posterior horn. Cases related to trisomy 18 and cytomegalovirus presented irregular ventricular walls associated with anomalous ventricular shapes, suggesting parenchymal destruction.
Conclusion
Ventricular morphology evaluation gives important information on etiology of ventricular enlargement, supporting prognosis prediction and decision making process of the affected fetuses and their families.
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References
Roza SJ, Govaert PP, Vrooman HA, Lequin MH, Hofman A, Steegers EA et al (2008) Foetal growth determines cerebral ventricular volume in infants. The Generation R Study. Neuroimage 39:1491–1498
Gaglioti P, Danelon D, Bontempo S, Mombro M, Cardaropoli S, Todros T (2005) Fetal cerebral ventriculomegaly: outcome in 176 cases. Ultrasound Obstet Gynecol 25:372–377
Kelly EN, Allen VM, Seaward G, Windrim R, Ryan G (2001) Mild ventriculomegaly in the fetus, natural history, associated findings and outcome of isolated mild ventriculomegaly: a literature review. Prenat Diagn 21:697–700
Lavinio A, Czosnyka Z, Czosnyka M (2008) Cerebrospinal fluid dynamics: disturbances and diagnostics. Eur J Anaesthesiol Suppl 42:137–141
Monteagudo A, Timor-Tritsch IE (2009) Normal sonographic development of the central nervous system from the second trimester onwards using 2D, 3D and transvaginal sonography. Prenat Diagn 29(4):326–339
Farell TA, Hertzberg BS, Kliewer MA, Harris L, Paine SS (1994) Fetal lateral ventricles: reassessment of normal values for atrial diameter at US. Radiology 193:409–411
Cardoza JD, Goldstein RB, Filly RA (1988) Exclusion of fetal ventriculomegaly with a single measurement: the width of the lateral ventricular atrium. Radiology 169:711–714
Yagel S (2001) Three-dimensional volumetry in fetal weight estimation, cerebral ventricle measurements and cardiac function. Ultrasound Obstet Gynecol 18:87
Monteagudo A, Timor-Trisch I, Mayberry P (2001) Three-dimensional sonographic evaluation of the fetal brain. In: Timor-Trisch IE, Cohen HL (eds) Ultrasonography of the prenatal and neonatal brain, 2nd edn. McGraw-Hill, New York, pp 359–392
Gilmore JH, Smith LC, Wolfe HM et al (2008) Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain. Biol Psychiatry 64:1069–1076
Raine-Fenning N, Campbell B, Collier J, Brincat M, Johnson I (2002) The reproducibility of endometrial volume acquisition and measurement with the VOCAL-imaging program. Ultrasound Obstet Gynecol 19:69–75
Garel C, Luton D, Oury JF, Gressens P (2003) Ventricular dilatations. Childs Nerv Syst 19:517–523
Oi S (2003) Diagnosis, outcome, and management of fetal abnormalities: fetal hydrocephalus. Childs Nerv Syst 19:508–516
Rickard S, Morris J, Paley M, Griffiths P, Whitby E (2006) In utero magnetic resonance of non-isolated ventriculomegaly: does ventricular size or morphology reflect pathology? Clin Radiol 61(10):844–853
Cavalheiro S, Moron AF, Zymberg ST, Dastoli P (2003) Fetal hydrocephalus—prenatal treatment. Childs Nerv Syst 19:561–573
Valat A, Dehouck M, Dufour P, Dubos J, Djebara A, Dewlamea L (2008) Ventriculomégalie cérébrale fœtale—Etiologie et devenir, à propos de 141observations. J Gynecol Obstet Biol Reprod 27:782–789
Pooh R, Pooh KH (2010) Fetal neuroimaging. Fetal Matern Med Rev 19:1–31
Gilmore JH, Gerig G, Specter B, Charles HC, Wilber JS, Hertzberg BS et al (2001) Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging. Ultrasound Med Biol 27:1143–1146
Martinez-Zamora MA, Borrell A, Borobio V et al (2007) False positives in the prenatal ultrasound screening of fetal structural anomalies. Prenat Diagn 27:18–22
Levine D, Trop I, Mehta TS, Barnes PD (2002) MR imaging appearance of fetal cerebral ventricular morphology. Radiology 223:652–659
Bennett GL, Bromley B, Benacerraf BR (1996) Agenesis of the corpus callosum: prenatal detection usually is not possible before 22 weeks of gestation. Radiology 199:447–450
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Haratz, K.K., Nardozza, L.M.M., de Oliveira, P.S. et al. Morphological evaluation of lateral ventricles of fetuses with ventriculomegaly by three-dimensional ultrasonography and magnetic resonance imaging: correlation with etiology. Arch Gynecol Obstet 284, 331–336 (2011). https://doi.org/10.1007/s00404-010-1666-z
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DOI: https://doi.org/10.1007/s00404-010-1666-z