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Radiochemotherapy versus radiotherapy in locally advanced cervical cancer: a meta-analysis

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The objectives of this review are to compare the effectiveness and safety of radiochemotherapy (RTCT) with radiotherapy (RT) alone in locally advanced cervical cancer (LACC).

Data sources

We comprehensively searched the Cochrane library, Medline, EMBASE, Chinese biomedicine literature database, Chinese scientific full-text database and Chinese journal full-text database for relevant articles. The computer search was supplemented with a manual search of reference lists for all available review articles. Also reference lists of the included studies were reviewed.

Results

We included 18 randomized trials involving 3,517 patients. Meta-analysis results are as follows: the response rate, 3 and 5-year survival rates were significantly better in patients in the RTCT group than in RT group. As adverse effects, limited evidence suggests that there was no significant difference between the two groups with regard to rectitis, cystitis, nausea and vomiting. But RTCT group has higher incidence rates than RT group in gastrointestinal, myelosuppression and leucopenia.

Conclusion

The combination of radiotherapy and chemotherapy was more effective for LACC than radiotherapy alone. There was no significant difference between the RTCT regimen group and RT regimen group with regard to adverse effects.

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Acknowledgments

We thank the following individuals for helpful comments at various stages of the review process: Lei jiang, Wen-Zhen Yuan, Peng Zhao, Xiao-Wei Wang, Yong-Xun Zhao.

Conflict of interest statement

None.

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Authors and Affiliations

  1. Oncological Surgery of First Hospital of Lanzhou University, Lanzhou, Gansu, China

    Na Wang, Quan-Lin Guan, Xin Zhou, Chen Gao, Han-Teng Yang & Tian-Gen Ni

  2. Department of Surgery of Second Hospital of Lanzhou University, Lanzhou, Gansu, China

    Kai Wang

Authors
  1. Na Wang
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  2. Quan-Lin Guan
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  3. Kai Wang
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  4. Xin Zhou
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  7. Tian-Gen Ni
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Corresponding author

Correspondence to Quan-Lin Guan.

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Wang, N., Guan, QL., Wang, K. et al. Radiochemotherapy versus radiotherapy in locally advanced cervical cancer: a meta-analysis. Arch Gynecol Obstet 283, 103–108 (2011). https://doi.org/10.1007/s00404-010-1385-5

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  • DOI: https://doi.org/10.1007/s00404-010-1385-5

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