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Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?

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Abstract

Background

Little is known about the relationship between serum magnesium (Mg) and C-reactive protein (CRP) in heart failure (HF).

Aim of the study

To investigate the relationship, if any, between serum Mg and CRP in HF patients and, concomitantly, to test a hypothesis that Mg supplementation might affect serum CRP levels.

Methods

Serum Mg and CRP were evaluated in 68 patients with chronic systolic HF leading to hospital admission and 65 patients requiring hospitalization for other causes. Following 5 weeks, serum Mg, CRP and intracellular Mg were reevaluated in 17 HF patients after administration of oral Mg citrate 300 mg/day (group A), and 18 untreated HF patients (group B). In order to obtain Gaussian distribution, logarithmic transformation of CRP was performed.

Results

Inverse correlation was found between serum Mg and log CRP (r = −0.28, P = 0.002). Compared to controls, patients with HF demonstrated higher baseline CRP levels, independent of coexisting conditions, and lower serum Mg values. Following Mg treatment, log CRP decreased from 1.4 ± 0.4 to 0.8 ± 0.3 in group A (P < 0.001). No significant changes in log CRP were demonstrable in group B. Serum Mg (mmol/l) rose significantly in group A (0.74 ± 0.04–0.88 ± 0.08, P < 0.001), and to a lesser extent in group B (0.82 ± 0.08–0.88 ± 0.08, P = 0.04). Intracellular Mg significantly increased only in Mg-treated group A (P = 0.01).

Conclusions

Oral Mg supplementation to HF patients significantly attenuates blood levels of CRP, a biomarker of inflammation. Targeting the inflammatory cascade by Mg administration might prove a useful tool for improving the prognosis in HF.

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Authors and Affiliations

  1. Dept. of Internal medicine “F”, Assaf Harofeh Medical Center, Zerifin, 70300, Israel

    Dorit Almoznino-Sarafian, Miriam Shteinshnaider, Oleg Gorelik, Irma Tzur, Irena Alon & Natan Cohen

  2. Dept. of Nephrology, Assaf Harofeh Medical Center, Zerifin, Israel

    Sylvia Berman & David Modai

  3. Dept. of Clinical Chemistry, Assaf Harofeh Medical Center, Zerifin, Israel

    Anat Mor

Authors
  1. Dorit Almoznino-Sarafian
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  2. Sylvia Berman
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  3. Anat Mor
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  9. Natan Cohen
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Correspondence to Natan Cohen.

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Almoznino-Sarafian, D., Berman, S., Mor, A. et al. Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?. Eur J Nutr 46, 230–237 (2007). https://doi.org/10.1007/s00394-007-0655-x

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  • DOI: https://doi.org/10.1007/s00394-007-0655-x

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