Zusammenfassung
Das primäre Sjögren-Syndrom ist mit einer Prävalenz zwischen 1:100 und 1:1000 die häufigste Kollagenose. Dennoch ist die Erkrankung wegen der überwiegend unspezifischen Symptome und der bei vielen Patienten fehlenden spezifischen Marker oft schwer zu diagnostizieren. Zudem wurden bislang nur wenige kontrollierte Therapiestudien durchgeführt, sodass die optimale Behandlung noch nicht klar ist. Mittlerweile wurden aber Outcomeparameter für den Therapieerfolg etabliert, sodass aktuell eine große Zahl klinischer Studien läuft. Im Review werden die aktuellen Diagnostik- und Behandlungsmöglichkeiten des primären Sjögren-Syndroms zusammengefasst.
Abstract
The prevalence of primary Sjögren’s syndrome (pSS) is between 1:100 and 1:1000 and it is therefore the most common connective tissue disease. Nevertheless, it can be difficult to diagnose pSS as the symptoms are frequently unspecific and diagnostic markers are lacking in many patients. In addition, only few controlled therapeutic studies of pSS have been carried out so that the optimal management is not yet clear. Meanwhile, outcome parameters to monitor clinical improvement have been developed and a large number of therapeutic studies are currently being performed. This review article summarizes the current diagnostic and treatment options for pSS.
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Witte, T. Sjögren-Syndrom. Z Rheumatol 78, 511–517 (2019). https://doi.org/10.1007/s00393-019-0625-8
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DOI: https://doi.org/10.1007/s00393-019-0625-8