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Entzündung und Knochen

Osteoimmunologische Aspekte

Inflammation and bone

Osteoimmunological aspects

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Zusammenfassung

Mikroskopische Frakturen (sog. „microcracks“) und unfallbedingte makroskopische Frakturen erfordern von Knochen als Grundgerüst des menschlichen Körpers eine hohe Regenerationsfähigkeit. Um diesen Anforderungen genügen zu können, sind sie permanenten Umbau- und Erneuerungsprozessen unterworfen. Ist die Knochenhomöostase jedoch gestört, führt dies zu Osteoporose oder anderen Knochenerkrankungen. Da das Immunsystem wesentlich an der Regulation der Knochenhomöostase beteiligt ist und insbesondere chronische Entzündungen diese aus dem Gleichgewicht bringen können, werden im Rahmen dieses Beitrags die osteoimmunologischen Aspekte beleuchtet, die zur Entstehung von Osteoporose und anderen Erkrankungen, die mit einer Knochendegradation einhergehen, beitragen.

Abstract

Microscopic fractures (so-called microcracks) or traumatic macrofractures require bone, as the basic scaffold of the human body, to have a high regenerative capability. In order to be able to provide this regenerative capability, bone is in a constant process of remodeling. This finely tuned homeostasis of bone formation and degradation can become disrupted, which leads to osteoporosis or other bone disorders. It has been shown that the immune system is substantially involved in the regulation of bone homeostasis and that chronic inflammation in particular can disturb this balance; therefore, this article reviews the osteoimmunological aspects contributing to osteoporosis and other diseases associated with bone degradation.

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Authors and Affiliations

  1. Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik Bad Nauheim, Rheumatologie und Klin. Immunologie, Justus-Liebig-Universität Gießen, Benekestr. 2–8, 61231, Bad Nauheim, Deutschland

    K. W. Frommer, E. Neumann & U. Lange

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  1. K. W. Frommer
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  2. E. Neumann
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  3. U. Lange
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Correspondence to K. W. Frommer.

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Interessenkonflikt

K.W. Frommer, E. Neumann und U. Lange geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Redaktion

U. Lange, Bad Nauheim

G. Schett, Erlangen

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Frommer, K.W., Neumann, E. & Lange, U. Entzündung und Knochen. Z Rheumatol 75, 444–450 (2016). https://doi.org/10.1007/s00393-016-0101-7

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  • DOI: https://doi.org/10.1007/s00393-016-0101-7

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