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Effektor-T-Zellen

Effector T cells

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Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Hintergrund

Unser Verständnis zu den Pathomechanismen und der Ätiologie rheumatischer Entzündungen ist noch sehr unvollständig. Es deutet jedoch viel darauf hin, dass Effektor-T-Zellen, insbesondere CD4+-Effektor-T-Helfer (Th)-Lymphozyten, hier eine zentrale Rolle spielen.

Ergebnisse

In den letzten Jahren wurden mehrere Untergruppen von Effektor-Th-Zellen beschrieben, die über die klassische Einteilung in Th1 und Th2 hinausgeht. Die Th-Subpopulationen wie Th1, Th2, Th9, Th17, Th22 und T-follikuläre Helferzellen (Tfh) unterscheiden sich in ihrer Expression von Zytokinen sowie Transkriptionsfaktoren und können unterschiedliche Funktionen ausüben.

Schlussfolgerung

Die wachsende Erkenntnis, welche Rolle diese unterschiedlichen T-Zell-Typen bei der Entzündung spielen, trägt zu einem besseren Verständnis hinsichtlich Entstehung und Chronifizierung rheumatischer Erkrankungen bei.

Abstract

Background

Although the present understanding of the immunopathogenesis of rheumatoid inflammation is still incomplete, there is substantial evidence that effector CD4+ T helper (Th) cells play a central role.

Results

In recent years, in addition to the established Th cell subsets Th1 and Th2 cells, other subsets, such as Th9, Th17, Th22 and T follicular helper (Tfh) cells have been described. Defining the contribution of T cells in the initiation and maintenance of inflammation has been augmented by the identification of functionally distinct subsets of effector Th cells that can be classified based on their cytokine and transcription factor profiles.

Conclusion

Increasing knowledge of the role of these various T cell populations in chronic inflammation provides a better understanding and insights into the pathogenic mechanisms and chronification of rheumatic diseases.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Leipe und H.-D. Chang geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Sektion für Rheumatologie und Klinische Immunologie, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Pettenkoferstr. 8a, 80336, München, Deutschland

    J. Leipe

  2. Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Deutschland

    H.-D. Chang

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  1. J. Leipe
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  2. H.-D. Chang
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Correspondence to J. Leipe.

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___Finanzielle Unterstützung_____

Jan Leipe erhielt für seine Forschungsarbeiten finanzielle Unterstützung durch die Deutsche Forschungsgemeinschaft (DFG LE 2784/1-1), Deutsche Gesellschaft für Rheumatologie (Start-up Förderung), Medizinische Fakultät der LMU (FöFoLE-Programm) und das Bundesministerium für Bildung und Forschung (IMPAM-Programm, Projekt 10, OIEC 1008H).

Hyun-Dong Chang erhielt für seine Forschungsarbeiten finanzielle Unterstützung durch die Deutsche Forschungsgemeinschaft (SFB650, SFB633 und SPP1468 Immunobone) und das Bundesministerium für Bildung und Forschung (IMPAM Fö-Kz. 01EC1008B und Immunopain Fö-Kz. 01EC1004A).

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Leipe, J., Chang, HD. Effektor-T-Zellen. Z. Rheumatol. 74, 14–19 (2015). https://doi.org/10.1007/s00393-014-1441-9

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  • DOI: https://doi.org/10.1007/s00393-014-1441-9

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