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Gender-spezifische Unterschiede der Komorbidität bei rheumatoider Arthritis

Gender-specific differences in comorbidities of rheumatoid arthritis

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Zusammenfassung

Hintergrund

Komorbiditäten haben bedeutenden Einfluss auf den Verlauf und die Therapie der rheumatoiden Arthritis (RA). Sie können sowohl in ihrer Häufigkeit als auch in der Ausprägung geschlechtsspezifische Unterschiede aufweisen.

Ziel der Arbeit

Die bisherigen Erkenntnisse über Gender-spezifische Aspekte der häufigsten Komorbiditäten bei RA werden zusammengefasst.

Material und Methoden

Es wurden nationale Daten ausgewertet. Die publizierten Ergebnisse aus Metaanalysen, Kohortenstudien und Reviews werden vorgestellt.

Ergebnisse

Es gibt geschlechtsspezifische Unterschiede in der Prävalenz der Begleiterkrankungen der RA. Depression, Fibromyalgie und Hypothyreose treten häufiger bei Frauen als bei Männern auf, während kardiovaskuläre Erkrankungen und Diabetes sich häufiger bei Männern als bei Frauen manifestieren. Arthrose und Osteoporose sind bei Männern und Frauen häufig.

Schlussfolgerung

Bei der Diagnostik und Therapie RA-assoziierter Komorbiditäten sollten mögliche geschlechtsspezifische Aspekte berücksichtigt werden.

Abstract

Background

Comorbidities play an important role in the course and therapy of rheumatoid arthritis (RA). Sex-specific aspects are observed with regard to prevalence and manifestation of RA-related comorbidities.

Aim

A summary of current insights into sex and gender-related aspects of frequent comorbidities in RA is given.

Material and methods

National data were analyzed and literature findings from meta-analyses, observational studies and reviews with regard to gender and RA-associated comorbidities are presented.

Results

There are gender-specific differences in the prevalence of comorbidities of RA. Depression, fibromyalgia and hypothyroidism are more frequent in women than in men, whereas cardiovascular diseases and diabetes are more common in men. Osteoarthritis and osteoporosis are frequent in both sexes.

Conclusion

Sex and gender-specific aspects should be taken into consideration in the diagnostics and treatment of RA-related comorbidities.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. K. Albrecht gibt an, dass kein Interessenkonflikt besteht. Der Beitrag enthält keine Studien an Menschen oder Tieren.

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Albrecht, K. Gender-spezifische Unterschiede der Komorbidität bei rheumatoider Arthritis. Z. Rheumatol. 73, 607–614 (2014). https://doi.org/10.1007/s00393-014-1410-3

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  • DOI: https://doi.org/10.1007/s00393-014-1410-3

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