Skip to main content
Log in

Th1-, Th17- und Th1+17-Zellen

Th1, Th17 and Th1+17 cells

  • Neues aus der Forschung
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

T-Helfer-Zellen tragen mit der Sekretion von Zytokinen zur Induktion und Aufrechterhaltung rheumatischer Entzündungen bei. Die Untersuchung von Interferon-γ-produzierenden Th1-Zellen, Interleukin-17-produzierenden Th17-Zellen und die vor Kurzem beschriebenen Th1+17-Zellen könnten Einblicke in pathophysiologische Mechanismen rheumatischer Entzündungen geben und zu neuen, gezielteren therapeutischen Ansätzen führen.

Abstract

T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases. This could lead to the development of novel, targeted therapeutic strategies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Afkarian M, Sedy JR, Yang J et al (2002) T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+T cells. Nat Immunol 3:549–557

    Article  PubMed  CAS  Google Scholar 

  2. Annunziato F, Cosmi L, Santarlasci V et al (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204:1849–1861

    Article  PubMed  CAS  Google Scholar 

  3. Bending D, De La Pena H, Veldhoen M et al (2009) Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 119:565–572

    Article  PubMed  CAS  Google Scholar 

  4. Codarri L, Gyülvészi G, Tosevski V et al (2011) RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12:560–567

    Article  PubMed  CAS  Google Scholar 

  5. Frey O, Meisel J, Hutloff A et al (2010) Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Ann Rheum Dis 69:1495–1501

    Article  PubMed  CAS  Google Scholar 

  6. Hot A, Miossec P (2011) Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes. Ann Rheum Dis 70:727–732

    Article  PubMed  CAS  Google Scholar 

  7. Infante-Duarte C, Horton HF, Byrne MC et al (2000) Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 165:6107–6115

    PubMed  CAS  Google Scholar 

  8. Janke M, Peine M, Nass A et al (2010) In-vitro-induced Th17 cells fail to induce inflammation in vivo and show an impaired migration into inflamed sites. Eur J Immunol 40:1089–1098

    Article  PubMed  CAS  Google Scholar 

  9. Kebir H, Ifergan I, Alvarez JI et al (2009) Preferential recruitment of interferon-gamma-expressing TH 17 cells in multiple sclerosis. Ann Neurol 66:390–402

    Article  PubMed  CAS  Google Scholar 

  10. Leipe J, Grunke M, Dechant C et al (2010) Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum 62:2876–2885

    Article  PubMed  CAS  Google Scholar 

  11. Leipe J, Schramm MA, Grunke M et al (2011) Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis 70:1453–1457

    Article  PubMed  CAS  Google Scholar 

  12. Lexberg MH, Taubner A, Forster A et al (2008) Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol 38:2654–2664

    Article  PubMed  CAS  Google Scholar 

  13. Sattler A, Wagner U, Rossol M et al (2009) Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. Blood 113:1948–1956

    Article  PubMed  CAS  Google Scholar 

  14. Schulz EG, Mariani L, Radbruch A et al (2009) Sequential polarization and imprinting of type 1T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 30:673–683

    Article  PubMed  CAS  Google Scholar 

  15. Zhou L, Littman DR (2009) Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol 21:146–152

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H.-D. Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, HD., Kamradt, T. & Schulze-Koops, H. Th1-, Th17- und Th1+17-Zellen. Z. Rheumatol. 70, 862–865 (2011). https://doi.org/10.1007/s00393-011-0779-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-011-0779-5

Schlüsselwörter

Keywords

Navigation