Zusammenfassung
T-Helfer-Zellen tragen mit der Sekretion von Zytokinen zur Induktion und Aufrechterhaltung rheumatischer Entzündungen bei. Die Untersuchung von Interferon-γ-produzierenden Th1-Zellen, Interleukin-17-produzierenden Th17-Zellen und die vor Kurzem beschriebenen Th1+17-Zellen könnten Einblicke in pathophysiologische Mechanismen rheumatischer Entzündungen geben und zu neuen, gezielteren therapeutischen Ansätzen führen.
Abstract
T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases. This could lead to the development of novel, targeted therapeutic strategies.
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Chang, HD., Kamradt, T. & Schulze-Koops, H. Th1-, Th17- und Th1+17-Zellen. Z. Rheumatol. 70, 862–865 (2011). https://doi.org/10.1007/s00393-011-0779-5
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DOI: https://doi.org/10.1007/s00393-011-0779-5