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Augenbeteiligung bei Kollagenosen und Vaskulitiden

Ocular involvement in connective tissue diseases and vasculitides

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Zusammenfassung

Kollagenosen und Vaskulitiden sind relativ häufig mit Augenmanifestationen assoziiert, welche zu schweren Komplikationen und sogar zur Erblindung führen können. Dieser Übersichtsartikel beschreibt die okulären Manifestationen, ihre Symptome und Häufigkeit sowie Therapieoptionen bei M. Sjögren, systemischem Lupus erythematodes (SLE), Antiphospholipidsyndrom (APLS), Riesenzellarteriitiden/Arteriitis cranialis, ANCA-assoziierten Vaskulitiden und M. Behçet. Darüber hinaus werden mögliche okuläre Nebenwirkungen von Malariamitteln beschrieben.

Abstract

Connective tissue diseases and systemic vasculitides are commonly associated with ocular manifestations, which can lead to severe complications and even blindness. The present review article describes these ocular manifestations, their signs and symptoms and possible treatment options for Sjoegren’s syndrome, systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APLS), as well as those of giant cell arteritis/cranial arteritis, ANCA-associated vasculitides and Behçet’s disease. Additionally, possible ocular adverse effects of antimalarial agents are described.

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Literatur

  1. Achkar AA, Lie JT, Hunder GG et al (1994) How does previous corticosteroid treatment affect the biopsy findings in giant cell (temporal) arteritis? Ann Intern Med 120:987–992

    CAS  PubMed  Google Scholar 

  2. Araza-Casillias R, Cárdenas F, Morales Y, Cardiel MH (2004) Factors associated with chloroquine-induced retinopathy in rheumatic diseases. Lupus 13:119–124

    Article  Google Scholar 

  3. Cursiefen C, Jacobi C, Dietrich T, Kruse FE (2006) Aktuelle Therapie des trockenen Auges. Ophthalmologe 103:18–24

    Article  CAS  PubMed  Google Scholar 

  4. Davies JB, Kumar Rao P (2008) Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 19:512–518

    Article  PubMed  Google Scholar 

  5. Deuter CME, Kötter I, Wallace GR et al (2008) Behçet’s disease: ocular effects and treatment. Prog Retin Eye Res 27:111–136

    Article  CAS  PubMed  Google Scholar 

  6. Dörner T (2010) Hydroxychloroquine in SLE: old drug, new perspectives. Nat Rev Rheumatol 6:10–11

    Article  PubMed  Google Scholar 

  7. Harper SL, Letko E, Samson CM et al (2001) Wegener’s granulomatosis: the relationship between ocular and systemic disease. J Rheumatol 28:1025–1032

    CAS  PubMed  Google Scholar 

  8. Hatemi G, Silman A, Bang D et al (2008) EULAR recommendations for the management of Behçet disease. Ann Rheum Dis 67:1656–1662

    Article  CAS  PubMed  Google Scholar 

  9. Jacobi C, Dietrich T, Cursiefen C, Kruse FE (2006) Das trockene Auge. Aktuelle Konzepte zu Klassifizierung, Diagnostik und Pathogenese. Ophthalmologe 103:9–17

    Article  CAS  PubMed  Google Scholar 

  10. Kassan SS, Moutsopoulos HM (2004) Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med 164:1275–1284

    Article  PubMed  Google Scholar 

  11. Metzler C, Schnabel A, Gross WL, Hellmich B (2008) A phase II study of interferon-alpha for the treatment of refractory Churg-Strauss syndrome. Clin Exp Rheumatol 26 (Suppl 49):S35–S40

    CAS  PubMed  Google Scholar 

  12. Neß T, Auw-Hädrich C, Schmidt D (2006) Riesenzellarteriitis (Arteriitis temporalis, Arteriitis cranialis). Ophthalmologe 103:296–301

    Article  PubMed  Google Scholar 

  13. Pakrou N, Selva D, Leibovitch I (2006) Wegener’s granulomatosis: ophthalmic manifestations and management. Semin Arthritis Rheum 35:284–292

    Article  PubMed  Google Scholar 

  14. Schmidt D, Neß T (2009) Augenbefunde und Differenzialdiagnosen bei Riesenzellarteriitis (Arteriitis cranialis). Z Rheumatol 68:117–123

    Article  CAS  PubMed  Google Scholar 

  15. Sivaraj RR, Durrani OM, Denniston AK et al (2007) Ocular manifestations of systemic lupus erythematosus. Rheumatol 46:1757–1762

    Article  CAS  Google Scholar 

  16. Stübiger N, Schlote T, Kötter I, Zierhut M (1999) Churg-Strauss-Syndrom. Klin Monbl Augenheilkd 214:171–174

    Article  PubMed  Google Scholar 

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Studienunterstützung durch Roche Pharma (Deuter, Kötter); Studienteilnahme und Drittmittel durch Novartis Pharma (Deuter).

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Deuter, C., Kötter, I. Augenbeteiligung bei Kollagenosen und Vaskulitiden. Z. Rheumatol. 69, 419–424 (2010). https://doi.org/10.1007/s00393-009-0579-3

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  • DOI: https://doi.org/10.1007/s00393-009-0579-3

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