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Epidemiologie der Augenbeteiligung beim Morbus Adamantiades-Behçet

Epidemiology of ocular involvement in Adamantiades-Behçets disease

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Zusammenfassung

Epidemiologische Studien ergeben eine Prävalenz für den Morbus Adamantiades-Behçet (MAB) in einer Spanne von 0,12–420 auf 100.000 Einwohner mit den höchsten Raten in der Türkei und den niedrigsten in den USA. Es existieren kaum ophthalmologische Daten in Deutschland, da die meisten epidemiologischen Studien auf dermatologischen oder rheumatologischen Daten beruhen. Aufgrund der internationalen Bevölkerungsstruktur bot sich Berlin für eine ophthalmologische epidemiologische Untersuchung an. Wir haben die wichtigsten uns vorliegenden epidemiologischen Daten von 140 Patienten (63 w, 77 m) mit einem durchschnittlichen Follow-up von 6,4 Jahren (0,5 bis 22 Jahre), die wir in den letzten Jahren publiziert haben, zusammengefasst. Das mittlere Alter zum Zeitpunkt der ersten Manifestationen betrug 23 Jahre. Das Vollbild der Erkrankung bot sich im Mittel mit 32 Jahren. Das durchschnittliche Alter bei Augenbeteiligung betrug 30 Jahre. Insgesamt trat eine Augenbeteiligung bei 56% der Betroffenen auf, bei 8,6% als Erstmanifestation und bei 19,3% als Zweitmanifestation. Die berechnete Prävalenz für Berlin betrug 1,77/100.000 Einwohner.

Abstract

Epidemiological studies demonstrate a prevalence of Adamantiades-Behçets disease (MAB) in the range of 0.12–420 per 100,000 inhabitants with the highest rates in Istanbul, Turkey and the lowest rates in the USA. Ophthalmological data on the prevalence of ocular involvement are limited for MAB in Germany because most epidemiological studies are based on rheumatological or dermatological data. Berlin is the city with the highest number of non-native German inhabitants and its multiethnic character renders it uniquely appropriate for epidemiological studies on MAB. This article summarizes the most important epidemiological data of 140 patients (63 female and 77 male) with a mean follow-up of 6.4 years (range 0.5–22 years) which we have recently published. The mean age was 23 years at the first manifestation and 32 years when the fully developed disease was recorded. The mean age at onset of ocular involvement was 30 years, 56% of patients developed ocular involvement, which was the first manifestation in 8.6% and the second manifestation in 19.3%. More than half the patients developed ocular involvement. The calculated prevalence of ocular involvement in MAB is 1.77/100,000 inhabitants for the population of Berlin.

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Authors and Affiliations

  1. Klinik für Augenheilkunde, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland

    C.E. Kneifel &  L. Krause

  2. Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau, Deutschland

    A. Altenburg & C.C. Zouboulis

  3. Augenklinik, Sankt Gertrauden-Krankenhaus, Berlin, Deutschland

    A.-K. Köhler

Authors
  1. C.E. Kneifel
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  2. A.-K. Köhler
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  3. A. Altenburg
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  4. C.C. Zouboulis
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  5. L. Krause
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Correspondence to L. Krause.

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Kneifel, C., Köhler, AK., Altenburg, A. et al. Epidemiologie der Augenbeteiligung beim Morbus Adamantiades-Behçet. Ophthalmologe 109, 542–547 (2012). https://doi.org/10.1007/s00347-011-2503-x

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  • DOI: https://doi.org/10.1007/s00347-011-2503-x

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