Abstract
Objectives
To evaluate the feasibility and safety of the application of robotic enucleation of adrenal masses (REAM).
Methods
Thirteen patients at Shanghai Changhai Hospital who underwent robotic enucleation of adrenal mass from February 2017 to March 2018 were reviewed. After mobilizing the adrenal gland and clamping the feeding blood vessels, the tumor was enucleated and reconstruction was performed. Relevant clinical data were recorded including baseline patient and tumor characteristics, and perioperative outcomes (operating time, ischemic time, estimated blood loss, complications, and so on).
Results
All cases were successfully completed without conversion to total adrenalectomy or open surgery. The mean operative time was 75 min (range 60–95), with a mean warm ischemia time of 12 min (range 8–17). The estimated blood loss was 20 mL (range 10–50). No intraoperative complications were observed, and no steroid replacement was given post-operatively. After a median follow-up period of 12 months (range 9–15), no evidence of disease recurrence was detected.
Conclusions
Robotic enucleation of adrenal masses is a safe and feasible procedure with excellent short-term functional and oncologic outcomes. Steroid supplementation is not necessary and recurrence is not usual with limited follow-up. Long-term follow-up and larger studies should be conducted to further evaluate outcomes of this robotic adrenal-sparing approach.
Similar content being viewed by others
References
Nehs MA, Ruan DT (2011) Minimally invasive adrenal surgery: an update. Curr Opin Endocrinol Diabetes Obes 18(3):193–197. https://doi.org/10.1097/MED.0b013e32834693bf
Wang HS, Li CC, Chou YH, Wang CJ, Wu WJ, Huang CH (2009) Comparison of laparoscopic adrenalectomy with open surgery for adrenal tumors. Kaohsiung J Med Sci 25(8):438–444. https://doi.org/10.1016/s1607-551x(09)70539-x
Hall DW, Raman JD (2010) Has laparoscopy impacted the indications for adrenalectomy? Curr Urol Rep 11(2):132–137. https://doi.org/10.1007/s11934-009-0089-5
Ball MW, Hemal AK, Allaf ME (2017) International Consultation on Urological Diseases and European Association of Urology International Consultation on Minimally Invasive Surgery in Urology: laparoscopic and robotic adrenalectomy. BJU Int 119(1):13–21. https://doi.org/10.1111/bju.13592
Kaye DR, Storey BB, Pacak K, Pinto PA, Linehan WM, Bratslavsky G (2010) Partial adrenalectomy: underused first line therapy for small adrenal tumors. J Urol 184(1):18–25. https://doi.org/10.1016/j.juro.2010.03.052
Diner EK, Franks ME, Behari A, Linehan WM, Walther MM (2005) Partial adrenalectomy: The National Cancer Institute experience. Urology 66(1):19–23. https://doi.org/10.1016/j.urology.2005.01.009
Davison AS, Jones DM, Ruthven S, Helliwell T, Shore SL (2018) Clinical evaluation and treatment of phaeochromocytoma. Ann Clin Biochem 55(1):34–48. https://doi.org/10.1177/0004563217739931
Pavan N, Derweesh I, Rassweiler J, Challacombe B, Zargar H, Porter J, Liatsikos E, Kaouk J, Porpiglia F, Autorino R (2017) Contemporary minimally invasive surgery for adrenal masses: it's not all about (pure) laparoscopy. BJU Int 119(2):201–203. https://doi.org/10.1111/bju.13701
Telenius-Berg M, Ponder MA, Berg B, Ponder BA, Werner S (1989) Quality of life after bilateral adrenalectomy in MEN 2. Henry Ford Hosp Med J 37(3–4):160–163
Walther MM, Keiser HR, Choyke PL, Rayford W, Lyne JC, Linehan WM (1999) Management of hereditary pheochromocytoma in von Hippel-Lindau kindreds with partial adrenalectomy. J Urol 161(2):395–398
Chen SF, Chueh SC, Wang SM, Wu VC, Pu YS, Wu KD, Huang KH (2014) Clinical outcomes in patients undergoing laparoscopic adrenalectomy for unilateral aldosterone producing adenoma: partial versus total adrenalectomy. J Endourol 28(9):1103–1106. https://doi.org/10.1089/end.2014.0102
Jeschke K, Janetschek G, Peschel R, Schellander L, Bartsch G, Henning K (2003) Laparoscopic partial adrenalectomy in patients with aldosterone-producing adenomas: indications, technique, and results. Urology 61(1):69–72
Wang L, Cai C, Liu B, Yang Q, Wu Z, Xiao L, Yang B, Chen W, Xu Z, Song S, Sun Y (2013) Perioperative outcomes and cosmesis analysis of patients undergoing laparoendoscopic single-site adrenalectomy: a comparison of transumbilical, transperitoneal subcostal, and retroperitoneal subcostal approaches. Urology 82(2):358–364. https://doi.org/10.1016/j.urology.2013.03.060
Ho CH, Liao PW, Lin VC, Jaw FS, Chueh SC, Chung SD, Liu SP, Tsai YC, Yu HJ (2015) Laparoendoscopic single-site (LESS) retroperitoneal partial adrenalectomy using a custom-made single-access platform and standard laparoscopic instruments: technical considerations and surgical outcomes. Asian J Surg 38(1):6–12. https://doi.org/10.1016/j.asjsur.2014.01.014
Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K, Gnarra JR, Reynolds JC, Glenn GM, Zbar B, Linehan WM (1999) Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. J Urol 162(3 Pt 1):659–664
Fu B, Zhang X, Wang GX, Lang B, Ma X, Li HZ, Wang BJ, Shi TP, Ai X, Zhou HX, Zheng T (2011) Long-term results of a prospective, randomized trial comparing retroperitoneoscopic partial versus total adrenalectomy for aldosterone producing adenoma. J Urol 185(5):1578–1582. https://doi.org/10.1016/j.juro.2010.12.051
Walz MK, Peitgen K, Diesing D, Petersenn S, Janssen OE, Philipp T, Metz KA, Mann K, Schmid KW, Neumann HP (2004) Partial versus total adrenalectomy by the posterior retroperitoneoscopic approach: early and long-term results of 325 consecutive procedures in primary adrenal neoplasias. World J Surg 28(12):1323–1329. https://doi.org/10.1007/s00268-004-7667-y
Ishidoya S, Ito A, Sakai K, Satoh M, Chiba Y, Sato F, Arai Y (2005) Laparoscopic partial versus total adrenalectomy for aldosterone producing adenoma. J Urol 174(1):40–43. https://doi.org/10.1097/01.ju.0000162045.68387.c3
Brandao LF, Autorino R, Zargar H, Krishnan J, Laydner H, Akca O, Mir MC, Samarasekera D, Stein R, Kaouk J (2014) Robot-assisted laparoscopic adrenalectomy: step-by-step technique and comparative outcomes. Eur Urol 66(5):898–905. https://doi.org/10.1016/j.eururo.2014.04.003
Yiannakopoulou E (2016) Robotic assisted adrenalectomy: Surgical techniques, feasibility, indications, oncological outcome and safety. Int J Surg Lond Engl 28:169–172. https://doi.org/10.1016/j.ijsu.2016.02.089
Simone G, De Nunzio C, Ferriero M, Cindolo L, Brookman-May S, Papalia R, Sperduti I, Collura D, Leonardo C, Anceschi U, Tuderti G, Misuraca L, Dalpiaz O, Hatzl S, Lodde M, Trenti E, Pastore AL, Palleschi G, Lotrecchiano G, Salzano L, Carbone A, De Cobelli O, Tubaro A, Schips L, Zigeuner R, Tostain J, May M, Guaglianone S, Muto G, Gallucci M (2016) Trends in the use of partial nephrectomy for cT1 renal tumors: Analysis of a 10-yr European Multicenter dataset. Eur J Surg Oncol 42(11):1729–1735. https://doi.org/10.1016/j.ejso.2016.03.022
St Julien J, Ball D, Schulick R (2006) Robot-assisted cortical-sparing adrenalectomy in a patient with Von Hippel-Lindau disease and bilateral pheochromocytomas separated by 9 years. J Laparoendosc Adv Surg Tech Part A 16(5):473–477. https://doi.org/10.1089/lap.2006.16.473
Boris RS, Gupta G, Linehan WM, Pinto PA, Bratslavsky G (2011) Robot-assisted laparoscopic partial adrenalectomy: initial experience. Urology 77(4):775–780. https://doi.org/10.1016/j.urology.2010.07.501
Simone G, Anceschi U, Tuderti G, Misuraca L, Celia A, De Concilio B, Costantini M, Stigliano A, Minisola F, Ferriero M, Guaglianone S, Gallucci M (2019) Robot-assisted partial adrenalectomy for the treatment of conn's syndrome: surgical technique, and perioperative and functional outcomes. Eur Urol 75(5):811–816. https://doi.org/10.1016/j.eururo.2018.07.030
Asher KP, Gupta GN, Boris RS, Pinto PA, Linehan WM, Bratslavsky G (2011) Robot-assisted laparoscopic partial adrenalectomy for pheochromocytoma: the National Cancer Institute technique. Eur Urol 60(1):118–124. https://doi.org/10.1016/j.eururo.2011.03.046
Author information
Authors and Affiliations
Contributions
CY: protocol development and manuscript writing; YY: data collection and manuscript writing; FG: data collection and data analysis; FW: data analysis; HW: data management; ZC: protocol development and manuscript writing; YB: protocol development and manuscript editing.
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no competing financial interests.
Human and animals rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Written informed consents from all enrolled patients were obtained.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ye, C., Yang, Y., Guo, F. et al. Robotic enucleation of adrenal masses: technique and outcomes. World J Urol 38, 853–858 (2020). https://doi.org/10.1007/s00345-019-02868-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00345-019-02868-7