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Gender effect on renal outcome in patients with urothelial carcinoma

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Abstract

Purpose

Taiwan is a highly endemic area for urothelial carcinoma (UC) and chronic kidney disease (CKD). We evaluate the gender effect on the relationship between renal outcome and clinical characteristics of CKD patients with UC.

Methods

The clinical and pathologic records of 404 patients were retrospectively analyzed. We calculated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) equation, and staged CKD status according to K/DOQI guideline.

Results

The female group had a significantly higher proportion (67.6% vs 29.0%, P < 0.001) of upper urinary tract urothelial carcinoma (UUT-UC). Pathologically, the frequency of high T stage UC (32.4% and 19.1%; P = 0.003), high-grade UC (89.4% and 75.6%; P = 0.001), and larger UC (51.4% and 37.8%; P = 0.009) in the female patients were significantly higher, when compared with the male group. Male gender, diabetes, anemia, poor preoperative renal function, UUT-UC, and low-grade tumor were independent risk factors of poor renal outcome by multivariate analysis in these UC patients. Diabetes was a risk factor of poor renal outcome in male UUT-UC patients, but not in the female patients (P = 0.009).

Conclusion

Female gender had a more aggressive histological urothelial carcinoma pattern than male patients did, but paradoxically had a more favorable renal outcome.

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Acknowledgments

This study was supported by grants from the National Science Council (NSC 97-2314-B-002-053-MY3) and Mrs. Hsiu-Chin Lee Kidney Foundation.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Chia-yi Christian Hospital, Chia-yi, Taiwan

    Peir-Haur Hung, Chih-Yen Hsiao & Pei-Chun Chiang

  2. Department of Urology, Chia-yi Christian Hospital, Chia-yi, Taiwan

    Cheng-Huang Shen

  3. Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-yi, Taiwan

    Hung-Bin Tsai

  4. Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    How-Ran Guo

  5. Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

    How-Ran Guo

  6. Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung-Shan South Road, Taipei, Taiwan

    Kuan-Yu Hung

  7. Department of Nursing, Chia-yi School, Chang Gung Institute of Technology, Chia-yi, Taiwan

    Peir-Haur Hung

Authors
  1. Peir-Haur Hung
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  2. Cheng-Huang Shen
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  3. Hung-Bin Tsai
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  4. Chih-Yen Hsiao
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  5. Pei-Chun Chiang
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  6. How-Ran Guo
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  7. Kuan-Yu Hung
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Corresponding author

Correspondence to Kuan-Yu Hung.

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Hung, PH., Shen, CH., Tsai, HB. et al. Gender effect on renal outcome in patients with urothelial carcinoma. World J Urol 29, 511–516 (2011). https://doi.org/10.1007/s00345-011-0682-3

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  • DOI: https://doi.org/10.1007/s00345-011-0682-3

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