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The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review

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Abstract

In this paper the association between smoking history, beverage consumption, diet and bladder cancer incidence is systematically reviewed. A rating system has been used to summarise the level of scientific evidence (i.e. convincing, probable, possible, and no evidence) and the level of association (i.e. substantially increased, (RR≥2.5), moderately increased (1.5≤RR<2.5), slightly increased (1.2≤RR<1.5), no association (0.8≤RR<1.2), slightly decreased (0.7≤RR<0.8), moderately decreased (0.4≤RR<0.7), and substantially decreased (RR<0.4)). There is convincing evidence that cigarette smoking status, frequency and duration substantially increase the risk of bladder cancer. However, the evidence is not clear for other forms of smoking. A small increased risk for cigar, pipe, and environmental smoking is only possible. There is possible evidence that total fluid intake is not associated with bladder cancer. Although there is convincing evidence for a positive association between alcohol consumption and bladder cancer risk in men, the risk is small and not clinically relevant. Coffee and tea consumption are probably not associated with bladder cancer. The authors conclude that total fruit consumption is probably associated with a small decrease in risk. There is probably no association between total vegetable intake, vitamin A intake, vitamin C intake and bladder cancer and a possibly moderate inverse association with vitamin E intake. Folate is possibly not associated with bladder cancer. There probably is a moderate inverse association between selenium intake and bladder cancer risk.

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References

  1. Steward BW, Kleinhaus P (2003) World Cancer Report. WHO-IARC, Lyon

  2. Lousbergh D, et al (2003) Incidence of cancer in the Belgian province of Limburg. LIKAS, Hasselt

  3. Visser O, Coeberg J, Dijck van J, Siesling S (2002) Incidence of cancer in the Netherlands 1998. Association of comprehensive cancer centres, Utrecht

  4. Schottenfeld D, Fraumeni JF (1996) Cancer epidemiology and prevention. Oxford University Press, New York, Oxford

  5. van der Meijden (1998) APM bladder cancer. British Medical Journal 317:1366–1369

    PubMed  Google Scholar 

  6. Bruyninckx R, Buntinx F, Aertgeerts B, Van Casteren V (2003) The diagnostic value of macroscopic haematuria for the diagnosis of urological cancer in general practice. Br J Gen Pract 53:31–35

    PubMed  Google Scholar 

  7. Buntinx F, Wauters H (1997) The diagnostic value of macroscopic haematuria in diagnosing urological cancers: a meta-analysis. Fam Pract 14:63–68

    Article  CAS  PubMed  Google Scholar 

  8. van der Windt DA, Zeegers MP, Kemper HC, Assendelft WJ, Scholten RJ (2000) Practice of systematic reviews. VI. Searching, selection and methodological evaluation of etiological research. Ned Tijdschr Geneeskd 144:1210–1214

    PubMed  Google Scholar 

  9. van den Brandt PA, et al (1990) A large-scale prospective cohort study on diet and cancer in the Netherlands. J Clin Epidemiol 43:285–95

    PubMed  Google Scholar 

  10. van den Brandt PA, Schouten LJ, Goldbohm RA, Dorant E, Hunen PHM (1990) Development of a record linkage protocol for use in the Dutch cancer registry for epidemiological research. Int J Epidemiol 19:553–558

    PubMed  Google Scholar 

  11. Barlow WE (1994) Robust variance estimation for the case-cohort design. Biometrics 50:1064–1072

    CAS  PubMed  Google Scholar 

  12. Barlow WE, Ichikawa L, Rosner D, Izumi S (1999) Analysis of case-cohort designs. J Clin Epidemiol 52:1165–1172

    Article  CAS  PubMed  Google Scholar 

  13. Zeegers MP, Goldbohm RA, van den Brandt PA (2001) Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev 10:1121–1128

    CAS  PubMed  Google Scholar 

  14. Zeegers MP, Goldbohm RA, van den Brandt, PA (2001) Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer 85:977–983

    Article  CAS  PubMed  Google Scholar 

  15. Zeegers MP, Dorant E, Goldbohm RA, van den Brandt PA (2001) Are coffee, tea, and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort Study. Cancer Causes Control 12:231–238

    Article  CAS  PubMed  Google Scholar 

  16. Zeegers MP, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA (2001) Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study. Am J Epidemiol 153:38–41

    Article  CAS  PubMed  Google Scholar 

  17. Zeegers MP, Goldbohm RA, Bode P, van den Brandt PA (2002) Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 11:1292–1297

    CAS  PubMed  Google Scholar 

  18. Zeegers MP, Goldbohm RA, van den Brandt PA (2002) A prospective study on active and environmental tobacco smoking and bladder cancer risk (The Netherlands). Cancer Causes Control 13:83–90

    PubMed  Google Scholar 

  19. World Cancer Research Fund & American Institute for Cancer Research (1997) Food, nutrition and the prevention of cancer: a global perspective. Banta Book Group, Menasha

  20. Rothman K, Greenland S (1998) Modern epidemiology. Lippincott-Raven Publishers, Philadelphia

  21. Sommer F, Klotz T, Schmitz-Dräger BJ (2004) Lifestyle issues and genitourinary tumours. World J Urol (in press) DOI 10.1007/s00345-003-0379-3

  22. Zeegers MP, Tan FE, Dorant E, van Den Brandt PA (2000) The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer 89:630–639

    Article  CAS  PubMed  Google Scholar 

  23. Brennan P, et al (2000) Cigarette smoking and bladder cancer in men: a pooled analysis of 11 case-control studies. Int J Cancer 86:289–294

    CAS  PubMed  Google Scholar 

  24. Brennan P, et al (2001) The contribution of cigarette smoking to bladder cancer in women (pooled European data). Cancer Causes Control 12:411–417

    Article  CAS  PubMed  Google Scholar 

  25. Castelao JE, et al (2001) Gender- and smoking-related bladder cancer risk. J Natl Cancer Inst 93:538–545

    Article  CAS  PubMed  Google Scholar 

  26. Matanoski GM, Elliott EA (1981) Bladder cancer epidemiology. Epidemiol Rev 3:203–229

    CAS  PubMed  Google Scholar 

  27. Morrison AS (1984) Control of cigarette smoking in evaluating the association of coffee drinking and bladder cancer. In: MacMahon B, Sugimura T (eds) Coffee and health. Cold Spring Harbor Laboratory, Spring Harbor, pp 127–136

  28. Dolin PJ (1991) An epidemiological review of tobacco use and bladder cancer. J Smoking Related Dis 2:129–143

    Google Scholar 

  29. Silverman DT, Hartge P, Morrison AS, Devesa SS (1992) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 6:1–30

    CAS  Google Scholar 

  30. Shirai T (1993) Etiology of bladder cancer. Semin Urol 11:113–126

    CAS  PubMed  Google Scholar 

  31. Shirai T, et al (1995) The etiology of bladder cancer: are there any new clues or predictors of behavior? Int J Urol 2[Suppl 3]: 64–75

  32. Silverman DT, Morrison AS, Devesa SS (1996) Bladder cancer. In: Schottenfeld D, Fraumeni JF (eds) Cancer epidemiology and prevention. Oxford University Press, New York, Oxford, pp 1156–79

  33. Ross RK, Jones PA, Yu MC (1996) Bladder cancer epidemiology and pathogenesis. Semin Oncol 23:536–545

    CAS  PubMed  Google Scholar 

  34. Johansson SL, Cohen SM (1997) Epidemiology and etiology of bladder cancer. Semin Surg Oncol 13:291–298

    CAS  PubMed  Google Scholar 

  35. Howe GR, et al (1980) Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J Natl Cancer Inst 64:701–713

    CAS  PubMed  Google Scholar 

  36. Burch JD, et al (1989) Risk of bladder cancer by source and type of tobacco exposure: a case-control study. Int J Cancer 44:622–628

    CAS  PubMed  Google Scholar 

  37. Jensen OM, Wahrendorf J, Blettner M, Knudsen JB, Sorensen BL (1987) The Copenhagen case-control study of bladder cancer: role of smoking in invasive and non-invasive bladder tumours. J Epidemiol Community Health 41:30–36

    CAS  PubMed  Google Scholar 

  38. Claude J, et al (1986) Life-style and occupational risk factors in cancer of the lower urinary tract. Am J Epidemiol 124:578–589

    CAS  PubMed  Google Scholar 

  39. Hartge P, Hoover R, Kantor A (1985) Bladder cancer risk and pipes, cigars and smokeless tobacco. Cancer 15:901–906

    Google Scholar 

  40. Steineck G, Norell SE, Feychting M (1988) Diet, tobacco and urothelial cancer: a 14-year follow-up of 16,477 subjects. Acta Oncol 27:323–327

    CAS  PubMed  Google Scholar 

  41. Morrison AS, et al (1984) An international study of smoking and bladder cancer. Journal d Urologie 131:650–654

    CAS  Google Scholar 

  42. Sandler DP, Everson RB, Wilcox AJ (1985) Passive smoking in adulthood and cancer risk. Am J Epidemiol 121:37–48

    CAS  PubMed  Google Scholar 

  43. Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin North Am 3:13–29

    CAS  PubMed  Google Scholar 

  44. Vineis P (1992) Epidemiological models of carcinogenesis: the example of bladder cancer. Cancer Epidemiol Biomarkers Prev 1:149–153

    CAS  PubMed  Google Scholar 

  45. Sandler DP, Wilcox AJ, Everson RB (1985) Cumulative effects of lifetime passive smoking on cancer risk. Lancet 1:312–315

    Article  CAS  PubMed  Google Scholar 

  46. Bos RP, Theuws JL, Henderson PT (1983) Excretion of mutagens in human urine after passive smoking. Cancer Lett 19:85–90

    CAS  PubMed  Google Scholar 

  47. Jensen OM, Wahrendorf J, Knudsen JB, Sorensen BL (1986) The Copenhagen case-control study of bladder cancer. II. Effect of coffee and other beverages. Int J Cancer 37:651–657

    CAS  PubMed  Google Scholar 

  48. Kunze E, Chang Claude J, Frentzel Beyme R (1992) Life style and occupational risk factors for bladder cancer in Germany. A case-control study. Cancer 69:1776–1790

    CAS  PubMed  Google Scholar 

  49. Vena JE, et al (1993) Drinking water, fluid intake and bladder cancer in western New York. Arch Environ Health 48:191–198

    CAS  PubMed  Google Scholar 

  50. Cantor KP, et al (1987) Bladder cancer, drinking water source, and tap water consumption: a case-control study. J Natl Cancer Inst 79:1269–1279

    CAS  PubMed  Google Scholar 

  51. Bianchi GD, et al (2000) Tea consumption and risk of bladder and kidney cancers in a population-based case-control study. Am J Epidemiol 151:377–383

    CAS  PubMed  Google Scholar 

  52. Risch HA, et al (1988) Dietary factors and the incidence of cancer of the urinary bladder. Am J Epidemiol 127:1179–1191

    CAS  PubMed  Google Scholar 

  53. Slattery ML, West DW, Robison LM (1988) Fluid intake and bladder cancer in Utah. Int J Cancer 42:17–22

    CAS  PubMed  Google Scholar 

  54. Dunham LJ, Rabson AS, Steward HS, Frank A, Young JL (1968) Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. J Natl Cancer Inst 41:683–709

    CAS  PubMed  Google Scholar 

  55. Wilkens LR, Kadir MM, Kolonel LN, Nomura AM, Hankin JH (1996) Risk factors for lower urinary tract cancer: the role of total fluid consumption, nitrites and nitrosamines, and selected foods. Cancer Epidemiol Biomarkers Prev 5:161–166

    CAS  PubMed  Google Scholar 

  56. Mills PK, Beeson WL, Phillips RL, Fraser GE (1991) Bladder cancer in a low risk population: results from the Adventist Health Study. Am J Epidemiol 133:230–239

    CAS  PubMed  Google Scholar 

  57. Michaud DS, et al Fluid intake and the risk of bladder cancer in men. N Engl J Med 340:1390–1397 (1999)

    Article  CAS  PubMed  Google Scholar 

  58. Zeegers MP, Tan FE, Goldbohm RA, van den Brandt PA (2001) Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis. Int J Epidemiol 30:353–362

    Article  CAS  PubMed  Google Scholar 

  59. World Health Organization (1991) IARC monographs on the evaluation of carcinogenic risks to humans: coffee, tea, mate, methylxanthines and methylgloxal. World Health Organization, Lyon

    Google Scholar 

  60. Nehlig A, Debry G (1996) Coffee and cancer: a review of human and animal data. World Rev Nutr Diet 79:185–221

    CAS  PubMed  Google Scholar 

  61. Negri E, La Vecchia C (2001) Epidemiology and prevention of bladder cancer. Eur J Cancer Prev 10:7–14

    Article  CAS  PubMed  Google Scholar 

  62. Jones PA, Ross RK (1999) Prevention of bladder cancer. N Engl J Med 340:1424–1426

    Article  CAS  PubMed  Google Scholar 

  63. Blot WJ (1999) Invited commentary: more evidence of increased risks of cancer among alcohol drinkers. Am J Epidemiol 150:1138–1140

    CAS  PubMed  Google Scholar 

  64. Berger A (1998) Science commentary: why wine might be less harmful than beer and spirits. BMJ 317:848

    PubMed  Google Scholar 

  65. Seitz HK, Simanowski UA (1988) Alcohol and carcinogenesis. Annu Rev Nutr 8:99–119

    Article  CAS  PubMed  Google Scholar 

  66. Garro AJ, Lieber CS Alcohol and cancer. Annu Rev Pharmacol Toxicol 30:219–49 (1990)

    Article  CAS  PubMed  Google Scholar 

  67. Freund G (1979) Possible relationships of alcohol in membranes to cancer. Cancer Res 39:2899–2901

    CAS  PubMed  Google Scholar 

  68. Lopez-Abente G, Escolar A (2001) Tobacco consumption and bladder cancer in non-coffee drinkers. J Epidemiol Community Health 55:68–70

    Article  CAS  PubMed  Google Scholar 

  69. Yang CS, Wang ZY (1993) Tea and cancer. J Natl Cancer Inst 85:1038–1049

    Article  CAS  PubMed  Google Scholar 

  70. Goldbohm RA, Hertog MG, Brants HA, van Poppel G, van den Brandt PA (1996) Consumption of black tea and cancer risk: a prospective cohort study. J Natl Cancer Inst 88:93–100

    CAS  PubMed  Google Scholar 

  71. Dreosti IE, Wargovich MJ, Yang CS (1997) Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr 37:761–770

    CAS  PubMed  Google Scholar 

  72. Dreosti IE (1996) Bioactive ingredients: antioxidants and polyphenols in tea. Nutr Rev 54: S51–S58

    CAS  Google Scholar 

  73. Katiyar SK, Mukhtar H (1996) Tea consumption and cancer. World Rev Nutr Diet 79:154–184

    CAS  PubMed  Google Scholar 

  74. Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151:693–702

    CAS  PubMed  Google Scholar 

  75. Michaud DS, et al (2002) Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer 87:960–965

    Article  CAS  PubMed  Google Scholar 

  76. Michaud DS, et al (2000) Prospective study of dietary supplements, macronutrients, micronutrients, and risk of bladder cancer in US men [In Process Citation]. Am J Epidemiol 152:1145–1153

    Article  CAS  PubMed  Google Scholar 

  77. Riboli E, et al (1991) Diet and bladder cancer in Spain: a multi-centre case-control study. Int J Cancer 49:214–219

    CAS  PubMed  Google Scholar 

  78. Vena JE, et al (1992) Diet in the epidemiology of bladder cancer in western New York. Nutr Cancer 18:255–264

    CAS  PubMed  Google Scholar 

  79. Shibata A, Paganini Hill A, Ross RK, Henderson BE (1992) Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer 66:673–679

    CAS  PubMed  Google Scholar 

  80. Nomura AMY, Kolonel LN, Hankin JH, Yoshizawa CN (1991) Dietary factors in cancer of the urinary tract. Int J Cancer 48:199–205

    CAS  PubMed  Google Scholar 

  81. Kolonel LN, Hinds MW, Nomura AM, Hankin JH, Lee J (1985) Relationship of dietary vitamin A and ascorbic acid intake to the risk for cancers of the lung, bladder, and prostate in Hawaii. Natl Cancer Inst Monogr 69:137–142

    CAS  PubMed  Google Scholar 

  82. Bruemmer B, White E, Vaughan TL, Cheney CL (1996) Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol 144:485–495

    CAS  PubMed  Google Scholar 

  83. Nomura A, Heilbrun LK, Morris JS, Stemmermann GN (1987) Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J Natl Cancer Inst 79:103–108

    CAS  PubMed  Google Scholar 

  84. Helzlsouer KJ, Comstock GW, Morris JS (1989) Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res 49:6144–6148

    CAS  PubMed  Google Scholar 

  85. Knekt P, et al (1990) Serum selenium and subsequent risk of cancer among Finnish men and women. J Natl Cancer Inst 82:864–868

    CAS  PubMed  Google Scholar 

  86. Garland M, et al (1995) Prospective study of toenail selenium and cancer among women. J Natl Cancer Inst 87:497–505

    Google Scholar 

  87. Steinmetz KA, Potter JD (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96:1027–1039

    Article  CAS  PubMed  Google Scholar 

  88. Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2:427–442

    CAS  PubMed  Google Scholar 

  89. Patterson RE, White E, Kristal AR, Neuhouser ML, Potter JD (1997) Vitamin supplements and cancer risk: the epidemiologic evidence. Cancer Causes Control 8:786–802

    Article  CAS  PubMed  Google Scholar 

  90. Kamat AM, Lamm DL (1999) Chemoprevention of urological cancer. J Urol 161:1748–1760

    Article  CAS  PubMed  Google Scholar 

  91. Birt DF (1986) Update on the effects of vitamins A, C, and E and selenium on carcinogenesis. Proc Soc Exp Biol Med 183:311–320

    CAS  PubMed  Google Scholar 

  92. Knekt P, et al (1988) Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 127:28–41

    CAS  PubMed  Google Scholar 

  93. Glynn SA, Albanes D (1994) Folate and cancer: a review of the literature. Nutr Cancer 22:101–119

    CAS  PubMed  Google Scholar 

  94. Blount BC, et al (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 94:3290–3295

    Article  CAS  PubMed  Google Scholar 

  95. Clark LC, et al (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. JAMA 276:1957–1963

    CAS  PubMed  Google Scholar 

  96. Salonen JT, Alfthan G, Huttunen JK, Puska P (1984) Association between serum selenium and the risk of cancer. Am J Epidemiol 120:342–349

    CAS  PubMed  Google Scholar 

  97. Willett WC, et al (1983) Prediagnostic serum selenium and risk of cancer. Lancet 2:130–134

    Article  CAS  PubMed  Google Scholar 

  98. Virtamo J, et al (1987) Serum selenium and risk of cancer. A prospective follow-up of nine years. Cancer 60:145–148

    CAS  PubMed  Google Scholar 

  99. Fan AM, Kizer KW (1990) Selenium: nutritional, toxicologic and clinical aspects. West J Med 153:160–167

    CAS  PubMed  Google Scholar 

  100. Brockmoller J, Kerb R, Drakoulis N, Staffeldt B, Roots I (1994) Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. Cancer Res 54:4103–4111

    PubMed  Google Scholar 

  101. Brockmoller J, Cascorbi I, Kerb R, Roots I (1996) Combined analysis of inherited polymorphisms in arylamine N- acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 56:3915–3925

    CAS  PubMed  Google Scholar 

  102. Marcus PM, et al (2000) Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev 9:461–467

    CAS  PubMed  Google Scholar 

  103. Spurr NK, Gough AC, Chinegwundoh FI, Smith CA (1995) Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk. Clin Chem 41:1864–1869

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD , Maastricht, The Netherlands

    Maurice P. A. Zeegers, Frank Buntinx & Piet A. van den Brandt

  2. Comprehensive Cancer Institute Limberg, Department of General Practice, University of Leuven, Kapucijnenvoer 33, blok J, 3000, Leuven, Belgium

    Maurice P. A. Zeegers, Eliane Kellen & Frank Buntinx

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  1. Maurice P. A. Zeegers
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Zeegers, M.P.A., Kellen, E., Buntinx, F. et al. The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review. World J Urol 21, 392–401 (2004). https://doi.org/10.1007/s00345-003-0382-8

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