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Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

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Abstract

To investigate how autoimmune thyroiditis (ATD) affects the clinical presentation of established rheumatoid arthritis (RA) with particular reference to fibromyalgia and chronic widespread pain (CWP). A cohort of 204 patients with RA for whom the presence or absence of autoimmune thyroid antibodies was documented was examined for the relationships between thyroid autoantibodies and fibromyalgia or CWP. We identified 29 % who tested positive for antithyroid peroxidase antibodies (TPOAb). The anti-thyroglobulin antibody (TgAb) was found in 24 %. Among the thyroid autoantibody-positive patients, 40 % had a diagnosis of fibromyalgia or CWP versus 17 % for antibody negative patients. Logistic regression analyses (adjusted by age, sex, diabetes and BMI) indicated that TPOAb-positive patients were more likely to have fibromyalgia or CWP, with an odds ratio (OR) of 4.641, 95 % confidence interval (CI) (2.110–10.207) P < .001. Adjusting for spinal degenerative disc disease did not change the association with fibromyalgia, OR 4.458, 95 % CI (1.950–10.191), P < .001. The OR between TgAb and fibromyalgia was not significant (P > .05). Additional logistic regression analyses (adjusted by age, sex and BMI) indicated a significant relationship between TPOAb and fibromyalgia or CWP in patients without diabetes and those without hypothyroidism (OR of 4.873, 95 % CI (1.877–12.653), P = .001 and OR of 4.615 95 % CI (1.810–11.770), P = .001, respectively). There may be a positive association between the ATD antibody TPOAb, and fibromyalgia syndrome and CWP in patients with established RA.

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Conflict of interest

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA

    Jowairiyya Ahmad

  2. Division of Geriatrics, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

    Helena Blumen

  3. Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

    Clement E. Tagoe

  4. Division of Rheumatology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467-2490, USA

    Clement E. Tagoe

Authors
  1. Jowairiyya Ahmad
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  2. Helena Blumen
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  3. Clement E. Tagoe
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Correspondence to Clement E. Tagoe.

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Ahmad, J., Blumen, H. & Tagoe, C.E. Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis. Rheumatol Int 35, 1415–1421 (2015). https://doi.org/10.1007/s00296-015-3278-1

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  • DOI: https://doi.org/10.1007/s00296-015-3278-1

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