Abstract
The objectives of this study are noninvasive assessment of endothelial dysfunction (ED) and diagnosing the possible early vascular development of atherosclerosis in psoriasis disease (PD). Twenty-eight PD patients (study group) without any obstructive vascular involvement were compared with 28 healthy controls (control group) in terms of ED utilizing endothelium-dependent dilation as well as endothelium-independent dilation, which was assessed by measuring changes in brachial artery diameter following sublingual glyceryl trinitrate (400 μg Nitrolingual spray). All patients underwent a complete transthoracic echocardiographic and tissue Doppler study. A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease. Statistical analysis was performed by utilizing SPSS version 11. There was no difference between patients and controls in terms of echocardiographic and tissue Doppler parameters as well as baseline brachial artery diameters. Flow-mediated dilation showed 37% impairment in study group compared with control (p < 0.05). Endothelium-independent NTG dilatation did not differ in both groups. Noninvasive methods such as ultrasonography, saving time and cost-effective, can be utilized for following outpatient PD patients for the risk of ED, which may preclude to atherosclerosis.
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References
Schön MP, Boehncke WH (2005) Psoriasis. N Engl J Med 352:1899–1912
McDonald CJ, Calabresi P (1978) Psoriasis and occlusive vascular disease. Br J Dermatol 99:469–475
Seishima M, Mori S, Noma A (1994) Serum lipid and apolipoprotein levels in patients with psoriasis. Br J Dermatol 130:738–742
Kannel WB (1995) Range of serum cholesterol values in the population developing coronary artery disease. Am J Cardiol 76:69–77
Malerba M, Gisondi P, Radaeli A, Sala R, Pinton PG, Girolomoni G (2006) Plasma homocystein and folate levels in patients with chronic plaque psoriasis. Br J Dermatol 155:1165–1169
Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y (2008) Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol 88:337–340
Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, DeanWeld JE (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111–1115
Ulusoy RE, Karabudak O, Kilicaslan F, Kirilmaz A, Us MH, Cebeci BS (2008) Noninvasive assessment of impaired endothelial dysfunction in mucocutaneous Behçet’s disease. Rheumatol Int 28:617–621
Ramsay B, Lawrence CM (1991) Measurement of involved surface area in patients with psoriasis. Br J Dermatol 124:565–570
Henry WL, De Maria A, Gramiak R, King DL, Kisslo JA, Popp RL, Sahn DJ, Schiller NB, Tajik A, Teicholz LE, Weyman AE (1980) Report of the American Society of Echocardiography Committee on nomenclature and standards in two-dimensional echocardiography. Circulation 62:212–217
Quiňones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA (2002) Recommendations for quantification of Doppler echocardiography: a report from the Doppler quantification task force of the nomenclature and standards committee of the American Society of Echocardiography. J Am Soc Echocardiogr 15:167–184
Agricola E, Galderisi M, Oppizzi M, Schinkel AFL, Maisano F, De Bonis M, Margonato A, Maseri A, Alfieri O (2004) Pulsed tissue Doppler imaging detects early myocardial dysfunction in asymptomatic patients with severe mitral regurgitation. Heart 90:406–410
Ormerod AD, Weller R, Copeland P, Benjamin N, Ralston SH, Grabowski P, Herriot R (1998) Detection of nitric oxide and nitric oxide synthases in psoriasis. Arch Dermatol Res 290:3–8
Verma S, Wang CH, Li SH, Dumont AS, Fedak PW, Badiwala MV, Dhillon B, Weisel RD, Li RK, Mickle DA, Stewart DJ (2002) A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 106:913–919
Korman NJ, Moul DK (2005) Alefacept for the treatment of psoriasis: a review of the current literature and practical suggestions for everyday clinical use. Semin Cutan Med Surg 24:10–18
Prinz JC (2005) Efalizumab. Long-term treatment of psoriasis. Hautarzt 56:812–818
Krathen RA, Berthelot CN, Hsu S (2006) Sustained efficacy and safety of infliximab in psoriasis: a retrospective study of 73 patients. J Drugs Dermatol 5:251–254
Sattar N, McCarey DW, Capell H, McInnes IB (2003) Explaining how “high-grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108:2957–2963
Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, Pineiro A, Garcia-Porrua C, Miranda-Filloy JA, Olliver WE, Martin J, Llorca J (2007) HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. Arthritis Rheum 57:125–132
Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J (2005) Rheumatoid arthritis: a disease associated with accelerated atherogenesis. Semin Arthritis Rheum 35:8–17
Milovanovic M, Nilsson E, Jaremo P (2004) Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta 343:237–240
Marongiu F, Sorano GG, Bibbo C, Pistis MP, Conti M, Mulas P, Balestrieri A, Biggio P (1994) Abnormalities of blood coagulation and fibrinolysis in psoriasis. Dermatology 189:32–37
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Ulusoy, R.E., Karabudak, O., Yokusoglu, M. et al. Noninvasive assessment of impaired endothelial function in psoriasis. Rheumatol Int 30, 479–483 (2010). https://doi.org/10.1007/s00296-009-0995-3
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DOI: https://doi.org/10.1007/s00296-009-0995-3