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Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis

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Abstract

The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of disease activity and bone turnover were registered in 343 postmenopausal women, 100 premenopausal women and 108 men with RA. Osteoporosis was found in a significantly higher percentage in postmenopausal women (55.7%) and in men (50.5%) in comparison with premenopausal women (18%; P < 0.001). The following risk factors for osteoporosis were found: older age, low BMI and high cumulative glucocorticoid dose in postmenopausal women, low BMI and high cumulative glucocorticoid dose in men and low BMI in premenopausal women. There is a very high prevalence of osteoporosis not only in postmenopausal women but also in men with RA. Osteoporosis risk factors are strongly dependent from gender and menopausal state.

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Authors and Affiliations

  1. Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich–Schiller University of Jena, Erlanger Allee 101, 07740, Jena, Germany

    Peter Oelzner, Antje Schwabe, Gabriele Lehmann, Thorsten Eidner, Sybille Franke, Gunter Wolf & Gert Hein

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  1. Peter Oelzner
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  2. Antje Schwabe
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  3. Gabriele Lehmann
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  7. Gert Hein
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Correspondence to Peter Oelzner.

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Oelzner, P., Schwabe, A., Lehmann, G. et al. Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis. Rheumatol Int 28, 1143–1150 (2008). https://doi.org/10.1007/s00296-008-0576-x

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  • DOI: https://doi.org/10.1007/s00296-008-0576-x

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