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Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis

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Abstract

The purpose of this study was to determine serum oxidative/antioxidative status in patients with knee osteoarthritis and its relation with prolidase activity, which plays an important role in collagen metabolism. Serum antioxidative status was evaluated by measuring total antioxidant capacity (TAC), thiol level and catalase enzyme activity in patients with osteoarthritis and in healthy controls. Serum oxidative status was evaluated by measuring total peroxide (TP) and lipid hydroperoxide. Oxidative stress index (OSI) was calculated. Prolidase enzyme activity was measured to investigate the collagen metabolism. Serum TAC, thiol level, catalase activity and prolidase activity were significantly lower in patients than in controls (P < 0.001, for all). In contrast, TP, lipid hydroperoxide and OSI values were significantly higher in patients than in controls (P < 0.001 for all). Further, prolidase activity was negatively correlated with TP and OSI, and positively correlated with TAC. The present results indicate that the oxidant parameters increased and antioxidant parameters decreased in patients with osteoarthritis; therefore, these patients may be exposed to a potent oxidative stress. Decreased collagen metabolism may be related with oxidative stress, which has a role in the ethiopathogenesis and/or in the progression of the disease.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medical Faculty, Research Hospital, Harran University, Sanliurfa, 63100, Turkey

    Ozlem Altindag

  2. Department of Biochemistry, Harran University, Sanliurfa, Turkey

    Ozcan Erel, Nurten Aksoy, Sahabettin Selek & Hakim Celik

  3. Department of Radiology, Harran University, Sanliurfa, Turkey

    Mustafa Karaoglanoglu

Authors
  1. Ozlem Altindag
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  2. Ozcan Erel
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  3. Nurten Aksoy
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  4. Sahabettin Selek
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  5. Hakim Celik
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  6. Mustafa Karaoglanoglu
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Correspondence to Ozlem Altindag.

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Altindag, O., Erel, O., Aksoy, N. et al. Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis. Rheumatol Int 27, 339–344 (2007). https://doi.org/10.1007/s00296-006-0247-8

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  • DOI: https://doi.org/10.1007/s00296-006-0247-8

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