References
Dupuis-Girod S, Bailly S, Plauchu H (2010) Hereditary hemorrhagic telangiectasia: from molecular biology to patient care. J Thromb Haemost 8(7):1447–1456
2 National Cancer Institute. Common Terminology Criteria for Adverse Events v 4.03 (CTCAE). Available at: http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf. Accessed 17 Mar 2016
Hoag JB, Terry P, Mitchell S et al (2010) An epistaxis severity score forhereditary hemorrhagic telangiectasia. Laryngoscope 120(4):838–843
Robinson K, Gatehouse S, Browning GG (1996) Measuring patient benefit from otorhinolaryngological surgery and therapy. Ann Otol Rhinol Laryngol 105(6):415–422
Mendel DB, Laird AD, Xin X et al (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and plateletderived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9:327–937
Kanellopoulou T, Alexopoulou A (2013) Bevacizumab in the treatment of hereditary hemorrhagic telangiectasia. Expert Opin Biol Ther 13(9):1315–1323
Geisthoff UW, Nguyen HL, Hess D (2014) Improvement in hereditary hemorrhagic telangiectasia after treatment with the phosphoinositide 3-kinase inhibitor BKM120. Ann Hematol 93(4):703–704
Acknowledgments
The authors would like to thank the patient and Dr. med. Marcus Koester for helping us with the follow-up of the patient and for providing information and discussion on Sunitinib.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. The study was approved by the Ethics Committee of the University Duisburg-Essen.
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Droege, F., Thangavelu, K., Lang, S. et al. Improvement in hereditary hemorrhagic telangiectasia after treatment with the multi-kinase inhibitor Sunitinib. Ann Hematol 95, 2077–2078 (2016). https://doi.org/10.1007/s00277-016-2796-6
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DOI: https://doi.org/10.1007/s00277-016-2796-6