References
Swerdlow SH, Campo E, Harris NL, Jaffe SS, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of tumours of haemtopoietic and lymphoid tissues. IARC, Lyon
Bartels S, Schipper E, Hasemeier B, Kreipe H, Lehmann U (2016) Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms. Oncotarget. doi:10.18632/oncotarget.8310
Muramatsu H, Makishima H, Maciejewski JP (2012) Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia: novel pathogenetic lesions. Semin Oncol 39:67–73. doi:10.1053/j.seminoncol.2011.11.004
Bartels S, Lehmann U, Büsche G, Schlue J, Mozer M, Stadler J, Triviai I, Alchalby H, Kröger N, Kreipe H (2015) SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation. Leukemia 29:253–255. doi:10.1038/leu.2014.277
Guglielmelli P, Lasho TL, Rotunno G, Score J, Mannarelli C, Pancrazzi A, Biamonte F, Pardanani A, Zoi K, Reiter A, Duncombe A, Fanelli T, Pietra D, Rumi E, Finke C, Gangat N, Ketterling RP, Knudson RA, Hanson CA, Bosi A, Pereira A, Manfredini R, Cervantes F, Barosi G, Cazzola M, Cross NC, Vannucchi AM, Tefferi A (2014) The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Leukemia 28:1804–1810. doi:10.1038/leu.2014.76
Lehmann U, Bartels S, Hasemeier B, Geffers R, Schlue J, Büsche G, Hussein K, Kreipe H (2013) SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis. Blood 121:4011–4012. doi:10.1182/blood-2012-11-467662
Boiocchi L, Espinal-Witter R, Geyer JT, Steinhilber J, Bonzheim I, Knowles DM, Fend F, Orazi A (2013) Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease. Mod Pathol 26:204–12. doi:10.1038/modpathol.2012.165
Ortmann CA, Kent DG, Nangalia J, Silber Y, Wedge DC, Grinfeld J, Baxter EJ, Massie CE, Papaemmanuil E, Menon S, Godfrey AL, Dimitripolou D, Guiglielmelli P, Bellosillo B, Besses C, Döhner K, Harrison CN, Vassiliou GS, Vannucchi A, Camphell PJ, Green AR (2015) Effect of mutation order on myeloproliferative neoplasms. N Engl J Med 372:601–612. doi:10.1056/NEJMoa1412098
Lundberg P, Karow A, Nienhold R, Looser R, Hao-Shen H, Nissen I, Girsberger S, Lehmann T, Passweg J, Stern M, Beisel C, Kralovics R, Skoda RC (2014) Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood 123:2220–2228. doi:10.1182/blood-2013-11-537167
Mason CC, Khorashad JS, Tantravahi SK, Kelley TW, Zabriskie MS, Yan D, Pomicter AD, Reynolds KR, Eiring AM, Kronenberg Z, Sherman RL, Tyner JW, Dalley BK, Dao KH, Yandell M, Drucker BJ, Gotlib J, O’Hare T, Deininger MW (2015) Age-related mutations and chronic myeloid leukemia. Leukemia 30:906–13. doi:10.1038/leu.2015.337
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The study was supported by a grant of the Deutsche Krebshilfe to HK and GB (grant number 1097154, TP A,D).
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Bartels, S., Lehmann, U., Büsche, G. et al. Evolution of chronic myelomonocytic leukemia to myeloproliferative neoplasm. Ann Hematol 95, 1377–1380 (2016). https://doi.org/10.1007/s00277-016-2699-6
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DOI: https://doi.org/10.1007/s00277-016-2699-6