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Physical activity, physical fitness and the effect of exercise training interventions in lymphoma patients: a systematic review

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Abstract

Fatigue is one of the most common and most distressing problems in lymphoma patients. A vicious circle is presumed between fatigue, physical activity and physical fitness. It is plausible that an exercise training program would be effective in reducing fatigue, by breaking this vicious circle. The purposes of this review are to provide an overview of the literature on physical activity and physical fitness in lymphoma patients before, during and after anticancer treatment, and to summarise the literature on exercise training interventions in lymphoma patients. We conducted a search for studies reporting on physical activity, physical fitness or the effect of exercise training in lymphoma patients. A total of 13 articles were selected. Due to a small number of articles and methodological issues, it was not possible to make final conclusions. The results indicated that 21 % to 29 % of lymphoma survivors meet the American College of Sports Medicine public health guidelines for physical activity. Maximal exercise capacity was decreased before treatment, especially in patients with advanced disease, and was close to normal during and/or after treatment. Lower levels of physical activity as well as lower physical fitness seemed to be associated with more symptoms of fatigue. Aerobic exercise training interventions seemed to be feasible and safe and had positive effects on cardiorespiratory fitness, fatigue and self-reported physical functioning. Further research is needed to examine physical activity and physical fitness in a longitudinal, objective way in large samples and to examine the effect of exercise training in lymphoma patients.

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References

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71–96

    Article  PubMed  Google Scholar 

  2. DeVita VT, Hellman S, Rosenberg S (2000) Cancer: principles and practice of oncology. 7th edition. J Lippincott, Philadelphia, PA

  3. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron R, Altekruse SF, Kosary CL, Kosary CL, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER cancer statistics review, 1975–2009 (vintage 2009 populations). National Cancer Institute, editor. 2012. Bethesda, MD.

  4. Cramp F, Daniel J (2008) Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev (2):CD006145.

  5. Ahlberg K, Ekman T, Gaston-Johansson F, Mock V (2003) Assessment and management of cancer-related fatigue in adults. Lancet 362(9384):640–650

    Article  PubMed  Google Scholar 

  6. Dimeo FC (2001) Effects of exercise on cancer-related fatigue. Cancer 92(6 Suppl):1689–1693

    Article  PubMed  CAS  Google Scholar 

  7. Siefert ML (2010) Fatigue, pain, and functional status during outpatient chemotherapy. Oncol Nurs Forum 37(2):E114–E123

    Article  PubMed  Google Scholar 

  8. Hjermstad MJ, Fossa SD, Oldervoll L, Holte H, Jacobsen AB, Loge JH (2005) Fatigue in long-term Hodgkin's disease survivors: a follow-up study. J Clin Oncol 23(27):6587–6595

    Article  PubMed  Google Scholar 

  9. Hjermstad MJ, Oldervoll L, Fossa SD, Holte H, Jacobsen AB, Loge JH (2006) Quality of life in long-term Hodgkin's disease survivors with chronic fatigue. Eur J Cancer 42(3):327–333

    Article  PubMed  Google Scholar 

  10. Ganz PA, Bower JE (2007) Cancer related fatigue: a focus on breast cancer and Hodgkin's disease survivors. Acta Oncol 46(4):474–479

    Article  PubMed  Google Scholar 

  11. Wagner LI, Cella D (2004) Fatigue and cancer: causes, prevalence and treatment approaches. Br J Cancer 91(5):822–828

    PubMed  CAS  Google Scholar 

  12. Liu RD, Chinapaw MJ, Huijgens PC, van Mechelen w (2009) Physical exercise interventions in haematological cancer patients, feasible to conduct but effectiveness to be established: a systematic literature review. Cancer Treat Rev 35(2):185–192

    Article  PubMed  Google Scholar 

  13. Brown JC, Huedo-Medina TB, Pescatello LS, Ryan SM, Pescatello SM, Moker E, LaCroix JM, Ferrer RA, Johnson BT (2012) The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. PLoS One 7(1):e30955

    Article  PubMed  CAS  Google Scholar 

  14. Hann D, Baker F, Denniston M, Gesme D, Reding D, Flynn T, Kennedy J, Kieltyka RL (2002) The influence of social support on depressive symptoms in cancer patients: age and gender differences. J Psychosom Res 52(5):279–283

    Article  PubMed  Google Scholar 

  15. Boettger S, Wetzig F, Puta C, Donath L, Muller HJ, Gabriel HH, Bar KJ (2009) Physical fitness and heart rate recovery are decreased in major depressive disorder. Psychosom Med 71(5):519–523

    Article  PubMed  Google Scholar 

  16. Burton C, McKinstry B, Szentagotai TA, Serrano-Blanco A, Pagliari C, Wolters M (2012). Activity monitoring in patients with depression: a systematic review. J Affect Disord August 4 (in press).

  17. Gilliam LA, Ferreira LF, Bruton JD, Moylan JS, Westerblad H, St Clair DK, Reid MB (2009) Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle. J Appl Physiol 107(6):1935–1942

    Article  PubMed  CAS  Google Scholar 

  18. Smith LA, Cornelius VR, Plummer CJ, Levitt G, Verrill M, Canney P, Jones A (2010) Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials. BMC Cancer 10:337

    Article  PubMed  CAS  Google Scholar 

  19. Batchelor TT, Taylor LP, Thaler HT, Posner JB, DeAngelis LM (1997) Steroid myopathy in cancer patients. Neurology 48(5):1234–1238

    Article  PubMed  CAS  Google Scholar 

  20. Fong DY, Ho JW, Hui BP, Lee AM, Macfarlane DJ, Leung SS, Cerin E, Chan WY, Leung IP, Lam SH, Taylor AJ, Cheng KK (2012) Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ 344:e70

    Article  PubMed  Google Scholar 

  21. Spence RR, Heesch KC, Brown WJ (2010) Exercise and cancer rehabilitation: a systematic review. Cancer Treat Rev 36(2):185–194

    Article  PubMed  Google Scholar 

  22. McNeely ML, Courneya KS (2010) Exercise programs for cancer-related fatigue: evidence and clinical guidelines. J Natl Compr Canc Netw 8(8):945–953

    PubMed  Google Scholar 

  23. Duijts SF, Faber MM, Oldenburg HS (2011) van BM, Aaronson NK. Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors—a meta-analysis. Psychooncology 20(2):115–126

    Article  PubMed  Google Scholar 

  24. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv 4(2):87–100

    Article  PubMed  Google Scholar 

  25. Rimer J, Dwan K, Lawlor DA, Greig CA, McMurdo M, Morley W, Mead GE. Exercise for depression. Cochrane Database Syst Rev 2012;7:CD004366.

  26. Mock V, Atkinson A, Barsevick AM, Berger AM, Cimprich B, Eisenberger MA, Hinds P, Kaldor P, Otis-Green SA, Piper BF (2007) Cancer-related fatigue. Clinical practice guidelines in oncology. J Natl Compr Canc Netw 5(10):1054–1078

    PubMed  Google Scholar 

  27. Surgeon General's report on physical activity and health. From the Centers for Disease Control and Prevention. JAMA 1996 August 21;276(7):522

  28. Kruk J, Aboul-Enein HY (2006) Physical activity in the prevention of cancer. Asian Pac J Cancer Prev 7(1):11–21

    PubMed  Google Scholar 

  29. Pitta F, Troosters T, Spruit MA, Decramer M, Gosselink R (2005) Activity monitoring for assessment of physical activities in daily life in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil 86(10):1979–1985

    Article  PubMed  Google Scholar 

  30. Westerterp KR (2009) Assessment of physical activity: a critical appraisal. Eur J Appl Physiol 105(6):823–828

    Article  PubMed  Google Scholar 

  31. Jones NL, Makrides L, Hitchcock C, Chypchar T, McCartney N (1985) Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis 131(5):700–708

    PubMed  CAS  Google Scholar 

  32. Wasserman K, Hansen JE, Sue DY (1994) Principles of exercise testing and interpretation. Lea and Febiger, Philadelphia

    Google Scholar 

  33. Troosters T, Gosselink R, Decramer M (1999) Six minute walking distance in healthy elderly subjects. Eur Respir J 14(2):270–274

    Article  PubMed  CAS  Google Scholar 

  34. Vallance JK, Courneya KS, Jones LW, Reiman T (2005) Differences in quality of life between non-Hodgkin's lymphoma survivors meeting and not meeting public health exercise guidelines. Psychooncology 14(11):979–991

    Article  PubMed  Google Scholar 

  35. Page E, Assouline D, Durand C, Brun O, Coeffic D, Fric D, Garnier C, Leyronnas C, Alcalay V, Aguilaniu B (2006) Stage-related changes in functional capacity in Hodgkin's disease: assessment by cardiopulmonary exercise testing before initiation of treatment. Ann Hematol 85(12):857–861

    Article  PubMed  Google Scholar 

  36. Lee JQ, Simmonds MJ, Wang XS, Novy DM (2003) Differences in physical performance between men and women with and without lymphoma. Arch Phys Med Rehabil 84(12):1747–1752

    Article  PubMed  Google Scholar 

  37. Courneya KS, Sellar CM, Stevinson C, McNeely ML, Peddle CJ, Friedenreich CM, Tankel K, Basi S, Chua N, Mazurek A, Reiman T (2009) Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol 27(27):4605–4612

    Article  PubMed  Google Scholar 

  38. Bellizzi KM, Rowland JH, Arora NK, Hamilton AS, Miller MF, Aziz NM (2009) Physical activity and quality of life in adult survivors of non-Hodgkin's lymphoma. J Clin Oncol 27(6):960–966

    Article  PubMed  Google Scholar 

  39. Habermann TM, Janney CA, Clark MM, Rummans TA, Sloan JS, Cerhan JR, Geyer SM, Thomas RJ. A pilot study of physical activity level and mood among long-term lymphoma survivors. Blood 2005;106.

  40. Ng AK, Li S, Recklitis C, Neuberg D, Chakrabarti S, Silver B, Diller L (2005) A comparison between long-term survivors of Hodgkin's disease and their siblings on fatigue level and factors predicting for increased fatigue. Ann Oncol 16(12):1949–1955

    Article  PubMed  CAS  Google Scholar 

  41. Oldervoll LM, Loge JH, Kaasa S, Lydersen S, Hjermstad MJ, Thorsen L, Holte H Jr, Jacobsen AB, Fossa SD (2007) Physical activity in Hodgkin's lymphoma survivors with and without chronic fatigue compared with the general population—a cross-sectional study. BMC Cancer 7:210

    Article  PubMed  Google Scholar 

  42. Elbl L, Vasova I, Tomaskova I, Jedlicka F, Kral Z, Navratil M, Smardova L, Wagnerova B, Vorlicek J (2006) Cardiopulmonary exercise testing in the evaluation of functional capacity after treatment of lymphomas in adults. Leuk Lymphoma 47(5):843–851

    Article  PubMed  Google Scholar 

  43. Oldervoll LM, Kaasa S, Knobel H, Loge JH (2003) Exercise reduces fatigue in chronic fatigued Hodgkins disease survivors—results from a pilot study. Eur J Cancer 39(1):57–63

    Article  PubMed  CAS  Google Scholar 

  44. Courneya KS, Stevinson C, McNeely ML, Sellar CM, Friedenreich CM, Peddle-McIntyre CJ, Chua N, Reiman T (2012) Effects of supervised exercise on motivational outcomes and longer-term behavior. Med Sci Sports Exerc 44(3):542–549

    Article  PubMed  Google Scholar 

  45. Courneya KS, Sellar CM, Stevinson C, McNeely ML, Friedenreich CM, Peddle CJ, Basi S, Chua N, Tankel K, Mazurek A, Reiman T (2009) Moderator effects in a randomized controlled trial of exercise training in lymphoma patients. Cancer Epidemiol Biomarkers Prev 18(10):2600–2607

    Article  PubMed  Google Scholar 

  46. Courneya KS, Stevinson C, McNeely ML, Sellar CM, Peddle CJ, Friedenreich CM, Mazurek A, Chua N, Tankel K, Basi S, Reiman T (2010) Predictors of adherence to supervised exercise in lymphoma patients participating in a randomized controlled trial. Ann Behav Med 40(1):30–39

    Article  PubMed  Google Scholar 

  47. Jacobs DR Jr, Ainsworth BE, Hartman TJ, Leon AS (1993) A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc 25(1):81–91

    Article  PubMed  Google Scholar 

  48. Johnson-Kozlow M, Sallis JF, Gilpin EA, Rock CL, Pierce JP (2006) Comparative validation of the IPAQ and the 7-day PAR among women diagnosed with breast cancer. Int J Behav Nutr Phys Act 3:7

    Article  PubMed  Google Scholar 

  49. Knols RH, de Bruin ED, Uebelhart D, Aaronson NK (2010) The relationship between ambulatory step activity, self-reported physical functioning and standardised timed walking in patients with haematological malignancies. Disabil Rehabil 32(22):1819–1826

    Article  PubMed  Google Scholar 

  50. Humpel N, Iverson DC (2010) Sleep quality, fatigue and physical activity following a cancer diagnosis. Eur J Cancer Care (Engl ) 19(6):761–768

    Article  CAS  Google Scholar 

  51. Rogers LQ, Markwell SJ, Verhulst S, McAuley E, Courneya KS (2009) Rural breast cancer survivors: exercise preferences and their determinants. Psychooncology 18(4):412–421

    Article  PubMed  Google Scholar 

  52. Belanger LJ, Plotnikoff RC, Clark A, Courneya KS (2011) Physical activity and health-related quality of life in young adult cancer survivors: a Canadian provincial survey. J Cancer Surviv 5(1):44–53

    Article  PubMed  Google Scholar 

  53. Blanchard CM, Stein K, Courneya KS (2010) Body mass index, physical activity, and health-related quality of life in cancer survivors. Med Sci Sports Exerc 42(4):665–671

    Article  PubMed  Google Scholar 

  54. Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R (2004) Physical activity levels among breast cancer survivors. Med Sci Sports Exerc 36(9):1484–1491

    PubMed  Google Scholar 

  55. Irwin ML (2009) Physical activity interventions for cancer survivors. Br J Sports Med 43(1):32–38

    Article  PubMed  CAS  Google Scholar 

  56. Basen-Engquist K, Hughes D, Perkins H, Shinn E, Taylor CC (2008) Dimensions of physical activity and their relationship to physical and emotional symptoms in breast cancer survivors. J Cancer Surviv 2(4):253–261

    Article  PubMed  Google Scholar 

  57. Guthold R, Ono T, Strong KL, Chatterji S, Morabia A (2008) Worldwide variability in physical inactivity a 51-country survey. Am J Prev Med 34(6):486–494

    Article  PubMed  Google Scholar 

  58. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 116(9):1081–1093

    Article  PubMed  Google Scholar 

  59. Courneya KS, Karvinen KH, Campbell KL, Pearcey RG, Dundas G, Capstick V, Tonkin KS (2005) Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol 97(2):422–430

    Article  PubMed  Google Scholar 

  60. Jones LW, Courneya KS, Vallance JK, Ladha AB, Mant MJ, Belch AR, Stewart DA, Reiman T (2004) Association between exercise and quality of life in multiple myeloma cancer survivors. Support Care Cancer 12(11):780–788

    Article  PubMed  Google Scholar 

  61. Rogers LQ, Courneya KS, Robbins KT, Malone J, Seiz A, Koch L, Rao K, Nagarkar M (2006) Physical activity and quality of life in head and neck cancer survivors. Support Care Cancer 14(10):1012–1019

    Article  PubMed  Google Scholar 

  62. Patterson RE, Neuhouser ML, Hedderson MM, Schwartz SM, Standish LJ, Bowen DJ (2003) Changes in diet, physical activity, and supplement use among adults diagnosed with cancer. J Am Diet Assoc 103(3):323–328

    PubMed  Google Scholar 

  63. Park CL, Edmondson D, Fenster JR, Blank TO (2008) Positive and negative health behavior changes in cancer survivors: a stress and coping perspective. J Health Psychol 13(8):1198–1206

    Article  PubMed  Google Scholar 

  64. Kenfield SA, Stampfer MJ, Giovannucci E, Chan JM (2011) Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study. J Clin Oncol 29(6):726–732

    Article  PubMed  Google Scholar 

  65. Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA, Fuchs CS (2006) Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol 24(22):3527–3534

    Article  PubMed  Google Scholar 

  66. Moorman PG, Jones LW, Akushevich L, Schildkraut JM (2011) Recreational physical activity and ovarian cancer risk and survival. Ann Epidemiol 21(3):178–187

    Article  PubMed  Google Scholar 

  67. Ruden E, Reardon DA, Coan AD, Herndon JE, Hornsby WE, West M, Fels DR, Desjardins A, Vredenburgh JJ, Waner E, Friedman AH, Friedman HS, Peters KB, Jones LW (2011) Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma. J Clin Oncol 29(21):2918–2923

    Article  PubMed  Google Scholar 

  68. Hayes SC, Davies PS, Parker TW, Bashford J, Green A (2004) Role of a mixed type, moderate intensity exercise programme after peripheral blood stem cell transplantation. Br J Sports Med 38(3):304–309

    Article  PubMed  CAS  Google Scholar 

  69. Jarden M, Hovgaard D, Boesen E, Quist M, Adamsen L (2007) Pilot study of a multimodal intervention: mixed-type exercise and psychoeducation in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant 40(8):793–800

    Article  PubMed  CAS  Google Scholar 

  70. Adamsen L, Quist M, Andersen C, Moller T, Herrstedt J, Kronborg D, Baadsgaard MT, Vistisen K, Midtgaard J, Christiansen B, Stage M, Kronborg MT, Rorth M (2009) Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ 339:b3410

    Article  PubMed  Google Scholar 

  71. Adamsen L, Quist M, Midtgaard J, Andersen C, Moller T, Knutsen L, Tveteras A, Rorth M (2006) The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy. Support Care Cancer 14(2):116–127

    Article  PubMed  Google Scholar 

  72. Quist M, Rorth M, Zacho M, Andersen C, Moeller T, Midtgaard J, Adamsen L (2006) High-intensity resistance and cardiovascular training improve physical capacity in cancer patients undergoing chemotherapy. Scand J Med Sci Sports 16(5):349–357

    Article  PubMed  CAS  Google Scholar 

  73. Thorsen L, Skovlund E, Stromme SB, Hornslien K, Dahl AA, Fossa SD (2005) Effectiveness of physical activity on cardiorespiratory fitness and health-related quality of life in young and middle-aged cancer patients shortly after chemotherapy. J Clin Oncol 23(10):2378–2388

    Article  PubMed  Google Scholar 

  74. Jones LW, Friedman AH, West MJ, Mabe SK, Fraser J, Kraus WE, Friedman HS, Tresch MI, Major N, Reardon DA (2010) Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. Cancer 116(3):695–704

    Article  PubMed  Google Scholar 

  75. Alberga AS, Segal RJ, Reid RD, Scott CG, Sigal RJ, Khandwala F, Jaffey J, Wells GA, Kenny GP (2012) Age and androgen-deprivation therapy on exercise outcomes in men with prostate cancer. Support Care Cancer 20(5):971–981

    Article  PubMed  Google Scholar 

  76. Segal RJ, Reid RD, Courneya KS, Sigal RJ, Kenny GP, Prud'Homme DG, Malone SC, Wells GA, Scott CG, Slovinec D'Angelo ME (2009) Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol 27(3):344–351

    Article  PubMed  Google Scholar 

  77. Win T, Sharples L, Groves AM, Ritchie AJ, Wells FC, Laroche CM (2008) Predicting survival in potentially curable lung cancer patients. Lung 186(2):97–102

    Article  PubMed  Google Scholar 

  78. Jones LW, Watson D, Herndon JE, Eves ND, Haithcock BE, Loewen G, Kohman L (2010) Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer 116(20):4825–4832

    Article  PubMed  Google Scholar 

  79. Gibbons WJ, Fruchter N, Sloan S, Levy RD (2001) Reference values for a multiple repetition 6-minute walk test in healthy adults older than 20 years. J Cardiopulm Rehabil 21(2):87–93

    Article  PubMed  CAS  Google Scholar 

  80. Carmack Taylor CL, Demoor C, Smith MA, Dunn AL, Basen-Engquist K, Nielsen I, Pettaway C, Sellin R, Massey P, Gritz ER (2006) Active for life after cancer: a randomized trial examining a lifestyle physical activity program for prostate cancer patients. Psychooncology 15(10):847–862

    Article  PubMed  Google Scholar 

  81. Culos-Reed SN, Robinson JW, Lau H, Stephenson L, Keats M, Norris S, Kline G, Faris P (2010) Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention. Support Care Cancer 18(5):591–599

    Article  PubMed  Google Scholar 

  82. Joly F, Alibhai SM, Galica J, Park A, Yi QL, Wagner L, Tannock IF (2006) Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer. J Urol 176(6 Pt 1):2443–2447

    Article  PubMed  CAS  Google Scholar 

  83. Basen-Engquist K, Taylor CL, Rosenblum C, Smith MA, Shinn EH, Greisinger A, Gregg X, Massey P, Valero V, Rivera E (2006) Randomized pilot test of a lifestyle physical activity intervention for breast cancer survivors. Patient Educ Couns 64(1–3):225–234

    Article  PubMed  Google Scholar 

  84. Yuen HK, Sword D (2007) Home-based exercise to alleviate fatigue and improve functional capacity among breast cancer survivors. J Allied Health 36(4):e257–e275

    PubMed  Google Scholar 

  85. Tang YJ, Wang CY, Wang CD, Dong YZ (2009) Clinical study of simultaneous lung volume reduction surgery during resection of pulmonary or esophageal neoplasms. Chin Med J (Engl ) 122(24):2973–2976

    Google Scholar 

  86. Mohan A, Singh P, Kumar S, Mohan C, Pathak AK, Pandey RM, Guleria R (2008) Effect of change in symptoms, respiratory status, nutritional profile and quality of life on response to treatment for advanced non-small cell lung cancer. Asian Pac J Cancer Prev 9(4):557–562

    PubMed  Google Scholar 

  87. Jones LW, Peddle CJ, Eves ND, Haykowsky MJ, Courneya KS, Mackey JR, Joy AA, Kumar V, Winton TW, Reiman T (2007) Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions. Cancer 110(3):590–598

    Article  PubMed  Google Scholar 

  88. Spruit MA, Polkey MI, Celli B, Edwards LD, Watkins ML, Pinto-Plata V, Vestbo J, Calverley PM, Tal-Singer R, Agusti A, Coxson HO, Lomas DA, MacNee W, Rennard S, Silverman EK, Crim CC, Yates J, Wouters EF (2012) Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease. J Am Med Dir Assoc 13(3):291–297

    Article  PubMed  Google Scholar 

  89. Alameri HF, Sanai FM, Al DM, Azzam NA, Al-Swat KA, Hersi AS, Abdo AA (2007) Six minute walk test to assess functional capacity in chronic liver disease patients. World J Gastroenterol 13(29):3996–4001

    PubMed  CAS  Google Scholar 

  90. Arslan S, Erol MK, Gundogdu F, Sevimli S, Aksakal E, Senocak H, Alp N (2007) Prognostic value of 6-minute walk test in stable outpatients with heart failure. Tex Heart Inst J 34(2):166–169

    PubMed  Google Scholar 

  91. Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, Nakanishi N, Miyatake K (2000) Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med 161(2 Pt 1):487–492

    Article  PubMed  CAS  Google Scholar 

  92. Kohl LM, Signori LU, Ribeiro RA, Silva AM, Moreira PR, Dipp T, Sbruzzi G, Lukrafka JL, Plentz RD (2012) Prognostic value of the six-minute walk test in end-stage renal disease life expectancy: a prospective cohort study. Clinics (Sao Paulo) 67(6):581–586

    Article  Google Scholar 

  93. Jones LW, Hornsby WE, Goetzinger A, Forbes LM, Sherrard EL, Quist M, Lane AT, West M, Eves ND, Gradison M, Coan A, Herndon JE, Abernethy AP (2012) Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer. Lung Cancer 76(2):248–252

    Article  PubMed  Google Scholar 

  94. Kasymjanova G, Correa JA, Kreisman H, Dajczman E, Pepe C, Dobson S, Lajeunesse L, Sharma R, Small D (2009) Prognostic value of the six-minute walk in advanced non-small cell lung cancer. J Thorac Oncol 4(5):602–607

    Article  PubMed  Google Scholar 

  95. Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E (2003) Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer 11(10):623–628

    Article  PubMed  Google Scholar 

  96. Dimeo FC, Stieglitz RD, Novelli-Fischer U, Fetscher S, Keul J (1999) Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer 85(10):2273–2277

    Article  PubMed  CAS  Google Scholar 

  97. Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J (1997) Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. Cancer 79(9):1717–1722

    Article  PubMed  CAS  Google Scholar 

  98. Carlson LE, Smith D, Russell J, Fibich C, Whittaker T (2006) Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: a pilot study. Bone Marrow Transplant 37(10):945–954

    Article  PubMed  CAS  Google Scholar 

  99. Baumann FT, Zopf EM, Nykamp E, Kraut L, Schule K, Elter T, Fauser AA, Bloch W (2011) Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention. Eur J Haematol 87(2):148–156

    Article  PubMed  Google Scholar 

  100. Baumann FT, Kraut L, Schule K, Bloch W, Fauser AA (2010) A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant 45(2):355–362

    Article  PubMed  CAS  Google Scholar 

  101. Elter T, Stipanov M, Heuser E, von Bergwelt-Baildon M, Bloch W, Hallek M, Baumann F (2009) Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma? Int J Hematol 90(2):199–204

    Article  PubMed  CAS  Google Scholar 

  102. Mello M, Tanaka C, Dulley FL (2003) Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 32(7):723–728

    Article  PubMed  CAS  Google Scholar 

  103. Wilson RW, Jacobsen PB, Fields KK (2005) Pilot study of a home-based aerobic exercise program for sedentary cancer survivors treated with hematopoietic stem cell transplantation. Bone Marrow Transplant 35(7):721–727

    Article  PubMed  CAS  Google Scholar 

  104. Courneya KS, Friedenreich CM, Sela RA, Quinney HA, Rhodes RE, Handman M (2003) The group psychotherapy and home-based physical exercise (group-hope) trial in cancer survivors: physical fitness and quality of life outcomes. Psychooncology 12(4):357–374

    Article  PubMed  Google Scholar 

  105. Shelton ML, Lee JQ, Morris GS, Massey PR, Kendall DG, Munsell MF, Anderson KO, Simmonds MJ, Giralt SA (2009) A randomized control trial of a supervised versus a self-directed exercise program for allogeneic stem cell transplant patients. Psychooncology 18(4):353–359

    Article  PubMed  Google Scholar 

  106. Knols RH, de Bruin ED, Uebelhart D, Aufdemkampe G, Schanz U, Stenner-Liewen F, Hitz F, Taverna C, Aaronson NK (2011) Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: a randomized clinical trial. Bone Marrow Transplant 46(9):1245–1255

    Article  PubMed  CAS  Google Scholar 

  107. Adamsen L, Quist M, Midtgaard J, Andersen C, Moller T, Knutsen L, Tveteras A, Rorth M (2006) The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy. Support Care Cancer 14(2):116–127

    Article  PubMed  Google Scholar 

  108. Lastayo PC, Marcus RL, Dibble LE, Smith SB, Beck SL (2011) Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility—an exploratory pilot study. BMC Geriatr 11:5

    Article  PubMed  Google Scholar 

  109. Hoffbrand AV, Moss PAH, Pettit JE. Essential haematology. [6]. 2011. Malden: Wiley-Blackwell, San Diego, CA.

  110. Jones LW, Eves ND, Haykowsky M, Joy AA, Douglas PS (2008) Cardiorespiratory exercise testing in clinical oncology research: systematic review and practice recommendations. Lancet Oncol 9(8):757–765

    Article  PubMed  Google Scholar 

  111. Kaasa S, Knobel H, Loge JH, Hjermstad MJ (1998) Hodgkin's disease: quality of life in future trials. Ann Oncol 9(Suppl 5):137–145

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was supported by a grant from the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (FWO).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, University Leuven, 3000, Leuven, Belgium

    Nele Vermaete & Rik Gosselink

  2. Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium

    Pascal Wolter

  3. Department of Haematology, Leuven Cancer Institute, Leuven, Belgium

    Gregor Verhoef

Authors
  1. Nele Vermaete
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  2. Pascal Wolter
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  3. Gregor Verhoef
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Correspondence to Rik Gosselink.

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Vermaete, N., Wolter, P., Verhoef, G. et al. Physical activity, physical fitness and the effect of exercise training interventions in lymphoma patients: a systematic review. Ann Hematol 92, 1007–1021 (2013). https://doi.org/10.1007/s00277-013-1689-1

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  • DOI: https://doi.org/10.1007/s00277-013-1689-1

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