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The prevalence and diagnostic value of toxocariasis in unknown eosinophilia

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Abstract

Toxocariasis is one of the causes of eosinophilia in peripheral blood and provokes eosinophilic infiltration in internal organs. Extended studies on the prevalence and clinical characteristics of toxocariasis have been rare. The aim of this study is to evaluate the prevalence of toxocariasis in unknown eosinophilia and to analyze the efficacy of toxocara enzyme-linked immunosorbent assay (ELISA). We evaluated patients presenting with peripheral blood eosinophilia (>500 cells/μl or ≥10% of white blood cell count). After checking drug histories and the presence of allergic diseases and parasitic infections, specific serum IgG antibody to Toxocara canis larval antigen was measured by ELISA. Liver and lung involvement was also evaluated. One-hundred and three patients were evaluated, and the mean age was 50.9 years old. Seventy patients (68.0%) were diagnosed as having toxocariasis. The patients who had a history of raw liver eating had a higher incidence, and the patients with liver involvement had higher serum eosinophil cationic protein values. The eosinophil count was normalized in 7 of 16 treated patients and in 25 of 54 untreated patients. The mean improvement duration was 12 months. We concluded that the prevalence of toxocariasis was high in patients with unknown eosinophilia, and the toxocara ELISA was essential for evaluation of the causes of unknown eosinophilia.

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References

  1. Arias Irigoyen J, Senent Sanchez CJ (1995) Toxocariasis: a cause of hyper IgE and eosinophilia. J Investig Allergol Clin Immunol 5:232–234

    PubMed  CAS  Google Scholar 

  2. Buijs J, Borsboom G, Renting M, Hilgersom WJ, van Wieringen JC, Jansen G et al (1997) Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children. Eur Respir J 10:1467–1475

    Article  PubMed  CAS  Google Scholar 

  3. Choi JH, SuhYJ, Jung JW, Song HJ, Suh CH, Hug S et al (2003) Clinical significance of serum ECP and sero-prevalence of human toxocariasis in patients with eosinophilia. J Asthma Allergy Clin Immunol 23:26–32

    Google Scholar 

  4. Despommier D (2003) Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev 16:265–272

    Article  PubMed  Google Scholar 

  5. Glickman LT, Cypess RH (1977) Toxocara infection in animal hospital employees. Am J Public Health 67:1193–1195

    PubMed  CAS  Google Scholar 

  6. Jacquier P, Gottstein B, Stingelin Y, Eckert J (1991) Immunodiagnosis of toxocarosis in humans: evaluation of a new enzyme-linked immunosorbent assay kit. J Clin Microbiol 29:1831–1835

    PubMed  CAS  Google Scholar 

  7. Jang JK, Paik SW, Choi MS, Lee JH, Koh KC, Chae GS et al (2001) Clinical characteristics of 19 cases of biopsy-proven eosinophilic liver abscess: single center experience. Korean J Gastroenterol 38:37–41

    Google Scholar 

  8. Johkoh T, Muller NL, Akira M, Ichikado K, Suga M, Ando M et al (2002) Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology 216:773–780

    Google Scholar 

  9. Kita H, Gleich GJ, Adolphson C (2003) Biology of eosinophils. In: Adkinson NF, Yunginger J, Busse W, Bochner B, Holgate S, Simons FE (eds) Middleton’s allergy principles and practice, 6th edn. Mosby, Philadelphia, pp 305–332

    Google Scholar 

  10. Magnaval JF, Berry A, Fabre R, Morassin B (2001) Eosinophil cationic protein as a possible marker of active human Toxocara infection. Allergy 56:1096–1099

    Article  PubMed  CAS  Google Scholar 

  11. Morris PD, Katerndahl DA (1987) Human toxocariasis. Review with report of a probable case. Postgrad Med 81:263–267

    PubMed  CAS  Google Scholar 

  12. Nash TE (2000) Visceral larva migrans and other unusual helminth infections. In: Mandell G, Bennett J, Dolin K (eds) Principles and practice of infectious disease, 5th edn. Churchill Livingstone, New York, pp 2965–2970

    Google Scholar 

  13. Obwaller A, Jensen-Jarolim E, Auer H, Huber A, Kraft D, Aspock H (1998) Toxocara infestations in humans: symptomatic course of toxocariasis correlates significantly with levels of IgE/anti-IgE immune complexes. Parasite Immunol 20:311–317

    Article  PubMed  CAS  Google Scholar 

  14. Pawlowski Z (2001) Toxocariasis in humans: clinical expression and treatment dilemma. J Helminthol 75:299–305

    Article  PubMed  CAS  Google Scholar 

  15. Rothenberg ME (1998) Eosinophilia. N Engl J Med 338:1592–1600

    Article  PubMed  CAS  Google Scholar 

  16. Shakib F, Pritchard DI, Walsh EA, Smith SJ, Powell-Richards A, Kumar S et al (1993) The detection of autoantibodies to IgE in plasma of individuals infected with hookworm (Necator americanus) and the demonstration of a predominant IgG1 anti-IgE autoantibody response. Parasite Immunol 15:47–53

    Article  PubMed  CAS  Google Scholar 

  17. Tefferi A (2005) Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment. Mayo Clin Proc 80:75–83

    Article  PubMed  Google Scholar 

  18. van Assendelft OW (1985) Reference values for the total and differential leukocyte count. Blood Cells 11:77–96

    PubMed  Google Scholar 

  19. Weller PF (2003) Eosinophilia and eosinophil-related disorders. In: Adkinson NF, Yunginger J, Busse W, Bochner B, Holgate S, Simons FE (eds) Middleton’s allergy principles and practice, 6th edn. Mosby, Philadelphia, pp 1105–1126

    Google Scholar 

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Authors and Affiliations

  1. Division of Allergy, Department of Medicine, Samsung Medical Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Nam-Hee Kwon, Mi-Jung Oh, Byung-Jae Lee & Dong-Chull Choi

  2. Department of Medicine, Ghil Medical Center, Gachon Medical School, Incheon, Korea

    Sang-Pyo Lee

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  1. Nam-Hee Kwon
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  2. Mi-Jung Oh
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  3. Sang-Pyo Lee
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  4. Byung-Jae Lee
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  5. Dong-Chull Choi
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Correspondence to Dong-Chull Choi.

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Kwon, NH., Oh, MJ., Lee, SP. et al. The prevalence and diagnostic value of toxocariasis in unknown eosinophilia. Ann Hematol 85, 233–238 (2006). https://doi.org/10.1007/s00277-005-0069-x

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  • DOI: https://doi.org/10.1007/s00277-005-0069-x

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