Abstract
Purpose
To describe the technique of percutaneous stereotactic radiofrequency ablation (SRFA) and its application in a patient with an unresectable multifocal intrahepatic cholangiocarcinoma (ICC).
Materials and Methods
A 72-year-old man presented with two nodules of an ICC with a maximum diameter of 10 and 4 cm, respectively. To produce overlapping ablation areas and cover the entire tumor volume, 18 paths for the placement of radiofrequency ablation (RFA) probes at multiple locations were planned on 2D and 3D reconstructions of the computed tomographic (CT) data. The 15-gauge coaxial needles were advanced through the aiming device to the preplanned depth. A control CT fused to the planning CT data confirmed correct needle placements. RFA was performed with an impedance-based multiple-electrode RFA system. Fusion of the contrast-enhanced control CT with the planning CT showed an appropriate zone of ablation.
Results
Besides a mild asymptomatic pleural effusion, no complications occurred. Twenty-seven months after the first RFA, two new small distant liver metastases were successfully treated by SRFA. Currently, 38 months after diagnosis and 36 months after the first SRFA, the patient is free of detectable disease.
Conclusion
SRFA seems to offer an effective treatment option in selected patients with even unresectable ICC.
References
de Groen PC, Gores GJ, LaRusso NF et al (1999) Biliary tract cancers. N Engl J Med 341:1368–1378
Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD (2005) Cholangiocarcinoma. Lancet 366:1303–1314
Aljiffry M, Abdulelah A, Walsh M et al (2009) Evidence-based approach to cholangiocarcinoma: a systematic review of the current literature. J Am Coll Surg 208:134–147
Anderson CD, Pinson CW, Berlin J, Chari RS (2004) Diagnosis and treatment of cholangiocarcinoma. Oncologist 9:43–57
Lau WY, Lai EC (2009) The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review. Ann Surg 249:20–25
Gillams AR, Lees WR (2009) Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation. Eur Radiol 19:1206–1213
Slakey DP (2002) Radiofrequency ablation of recurrent cholangiocarcinoma. Am Surg 68:395–397
Chiou YY, Hwang JI, Chou YH et al (2005) Percutaneous ultrasound-guided radiofrequency ablation of intrahepatic cholangiocarcinoma. Kaohsiung J Med Sci 21:304–309
Zgodzinski W, Espat NJ (2005) Radiofrequency ablation for incidentally identified primary intrahepatic cholangiocarcinoma. World J Gastroenterol 11:5239–5240
Rai R, Manas D, Rose J (2005) Radiofrequency ablation of recurrent cholangiocarcinoma after orthotopic liver transplantation—a case report. World J Gastroenterol 11:612–613
Bale R, Widmann G (2007) Navigated CT-guided interventions. Minim Invasive Ther Allied Technol 16:196–204
Bale R, Widmann G, Stoffner DI (2010) Stereotaxy: breaking the limits of current radiofrequency ablation techniques. Eur J Radiol 75:32–36
Nevinny-Stickel M, Sweeney RA, Bale RJ et al (2004) Reproducibility of patient positioning for fractionated extracranial stereotactic radiotherapy using a double-vacuum technique. Strahlenther Onkol 180:117–122
Laeseke PF, Sampson LA, Haemmerich D et al (2006) Multiple-electrode radiofrequency ablation creates confluent areas of necrosis: in vivo porcine liver results. Radiology 241:116–124
Goldberg SN, Grassi CJ, Cardella JF et al (2005) Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology 235:728–739
Cunningham SC, Choti MA, Bellavance EC, Pawlik TM (2007) Palliation of hepatic tumors. Surg Oncol 16:277–291
Kim JH, Yoon HK, Sung KB et al (2008) Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes. Cancer 113:1614–1622
Aliberti C, Benea G, Tilli M, Fiorentini G (2008) Chemoembolization (TACE) of unresectable intrahepatic cholangiocarcinoma with slow-release doxorubicin-eluting beads: preliminary results. Cardiovasc Intervent Radiol 31:883–888
Shiina S, Teratani T, Obi S et al (2005) A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 129:122–130
Veltri A, Sacchetto P, Tosetti I et al (2008) Radiofrequency ablation of colorectal liver metastases: small size favorably predicts technique effectiveness and survival. Cardiovasc Intervent Radiol 31:948–956
Conflict of interest
The first author is a co-inventor of the Atlas aiming device and the BodyFix double-vacuum immobilization system and a co-shareholder in their financial returns.
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R. Bale and M. Haidu contributed equally to this work.
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Bale, R., Widmann, G. & Haidu, M. Stereotactic Radiofrequency Ablation. Cardiovasc Intervent Radiol 34, 852–856 (2011). https://doi.org/10.1007/s00270-010-9966-z
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DOI: https://doi.org/10.1007/s00270-010-9966-z