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The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

  • Original Article
  • Non-Surgical Aesthetic
  • Published:
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Abstract

Introduction

In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Attractive features of PRP are the extended release of various growth and differentiation factors from activated platelets, tissue regenerative, and healing capabilities, as well as the lack of problems associated with immunogenicity. Because of the unique biological features of this whole blood-derived biological agent, multiple clinical uses for PRP exist for aesthetic and regenerative medicine.

Evidence Acquisitions

A comprehensive review of the literature regarding the use of platelet-rich plasma in aesthetic and regenerative medicine was performed.

Evidence Synthesis

Therapeutic applications of PRP including several methods for its clinical deployment in conditions related to aesthetic and regenerative medicine including wound healing, skin and facial rejuvenation, hair restoration, hand rejuvenation, breast augmentation, and musculoskeletal regeneration were reviewed.

Conclusion

PRP treatment has shown itself as a bright future for a safe and efficient cosmetic intervention. However, more studies are needed to better our understanding of limitations and benefits in clinical phases associated with the aesthetic use of PRP.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Abbreviations

PRP:

Platelet-rich plasma

GF:

Growth factor

VEGF:

Vascular endothelial growth factor

PDGF:

Platelet-derived growth factor

EGF:

Epidermal growth factor

TGF-β:

Transforming growth factor beta

FGF:

Fibroblast growth factor

IGF-1:

Insulin-like growth factor 1

PDEGF:

Platelet-derived epidermal growth factor

PDAF:

Platelet-derived angiogenesis factor

PF-4:

Platelet factor 4

IL-1:

Interleukin-1

I-A:

Interferon alpha

I-G:

Interferon gamma

AGA:

Androgenetic alopecia

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Acknowledgements

We wish to express our sincere thanks to Dr. Roger S Hogue for his valuable comments.

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Authors and Affiliations

  1. Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Pouria Samadi, Mohsen Sheykhhasan & Hamed Manoochehri Khoshinani

  2. Department of Mesenchymal Stem Cell, The Academic Center for Education, Culture and Research, Qom Branch, Qom, Iran

    Mohsen Sheykhhasan

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  1. Pouria Samadi
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  2. Mohsen Sheykhhasan
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Correspondence to Mohsen Sheykhhasan.

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Samadi, P., Sheykhhasan, M. & Khoshinani, H.M. The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review. Aesth Plast Surg 43, 803–814 (2019). https://doi.org/10.1007/s00266-018-1293-9

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