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Camouflage and sabotage: tumor escape from the immune system

  • Focussed Research Review
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Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

The field of tumor immunology has made great progress in understanding tumor immune interactions. As a consequence a number of immuno-therapeutic approaches have been successfully introduced into the clinic and a large number of promising therapeutic strategies are investigated in ongoing clinical trials. Evaluation of anti-tumor immunity in such trials as well as in animal models has shown that tumor escape from immune recognition and tumor-mediated suppression of anti-tumor immunity can pose a significant obstacle to successful cancer therapy. Here, we review mechanisms of tumor immune escape and immune-subversion with a focus on the research interests in our laboratory: loss of MHC class I on tumor cells, increased oxidative stress, recruitment of myeloid-derived suppressor cells, and regulatory T cells.

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Acknowledgments

Kiessling’s research group is supported by grants from the Swedish Cancer Society, the Swedish Medical Research Council, the Cancer Society of Stockholm, the European Union (Grants “EUCAAD” and “DC-THERA”), the Karolinska Institutet, Lars-Hiertas Memorial Foundation and an “ALF-Project” grant from the Stockholm City Council.

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  1. Department of Oncology and Pathology, Cancer Center Karolinska R8:01, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden

    Isabel Poschke, Dimitrios Mougiakakos & Rolf Kiessling

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  1. Isabel Poschke
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  2. Dimitrios Mougiakakos
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Correspondence to Isabel Poschke.

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Poschke, I., Mougiakakos, D. & Kiessling, R. Camouflage and sabotage: tumor escape from the immune system. Cancer Immunol Immunother 60, 1161–1171 (2011). https://doi.org/10.1007/s00262-011-1012-8

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