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Clinical impact of 11C-methionine PET on expected management of patients with brain neoplasm

  • Original Article
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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

An Erratum to this article was published on 27 January 2010

Abstract

Purpose

We retrospectively examined the clinical efficacy of 11C-methionine positron emission tomography (11C-MET PET) in patients with brain neoplasm, especially whether the 11C-MET PET changed the clinical management and whether the change was beneficial or detrimental.

Methods

This study reviewed 89 11C-MET PET scans for 80 patients (20 scans for initial diagnosis of brain tumor and 69 scans for differentiating tumor recurrence from radiation necrosis). Final diagnosis and the effect on the intended management were obtained from the questionnaire to the referring physicians or directly from the medical records. The diagnostic sensitivity, specificity, and accuracy for the 11C-MET PET were evaluated. Regarding the management impact, the rate of scans that caused changes in intended management was also evaluated. Moreover, the occurrence of scans having detrimental diagnostic impact (DDI) and beneficial diagnostic impact (BDI) were evaluated.

Results

Sensitivity, specificity, and accuracy of 11C-MET PET was 87.8, 80.0, and 85.9%. The intended management was changed in 50.0% of the scans. DDI and BDI were observed in 4.3 and 36.2% of the total relevant scans, respectively.

Conclusion

11C-MET PET can provide useful information in initial diagnosis and differentiating tumor recurrence from radiation necrosis. The intended management was changed in half of the scans. Since a few cases did not receive the requisite treatment due to false-negative results of 11C-MET PET, management decision should be made carefully, especially in the case of a negative scan.

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Authors and Affiliations

  1. Division of Molecular imaging, Institution of Biomedical Research and Innovation, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan

    Tomohiko Yamane & Michio Senda

  2. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

    Setsu Sakamoto

Authors
  1. Tomohiko Yamane
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  2. Setsu Sakamoto
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  3. Michio Senda
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Correspondence to Tomohiko Yamane.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00259-009-1372-x

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Yamane, T., Sakamoto, S. & Senda, M. Clinical impact of 11C-methionine PET on expected management of patients with brain neoplasm. Eur J Nucl Med Mol Imaging 37, 685–690 (2010). https://doi.org/10.1007/s00259-009-1302-y

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  • DOI: https://doi.org/10.1007/s00259-009-1302-y

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