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Microbial Ecology of the Human Skin

  • Human Microbiome
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Abstract

This review article on the skin microbiota was written in response to recent advances that transitioned from culture methods to PCR amplification and sequencing of bacterial and fungal genes as a result of the Human Microbiome Project. This transition enables the investigation of the full diversity of microorganisms inhabiting human skin. The skin provides a range of habitats with different microbiota associated with the three major regions of the skin, namely the moist axilla, perineum, and toe webs; oily or sebaceous head, neck, and trunk; and dry forearms and legs. These new culture-independent tools are revealing the diversity of the human skin microbiota in the different locations of the body and with skin depth. These tools should lead to a better understanding of the state of homeostasis between the microbiota and the host and the overall functionality of that microbiota.

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References

  1. Noble WC (1981) Microbiology of human skin, 2nd edn. Lloyd-Luke, London, p 443

    Google Scholar 

  2. Hannigan GD, Grice EA (2013) Microbial ecology of skin in the era of metagenomics and molecular microbiology. Cold Spring Harb Perspect Med 3:a015362

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Grice EA et al (2009) Topographical and temporal diversity of the human skin microbiome. Science 324:1190–1192

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Grice EA, Segre JA (2011) The skin microbiota. Nat Res Microbiol 9:244–253

    Article  CAS  Google Scholar 

  5. Fuchs E, Raghaven S (2002) Getting under the skin of epidermal morphogenesis. Nat Rev Genet 3(3):199–209

    Article  PubMed  CAS  Google Scholar 

  6. Segre JA (2006) Epidermal barrier formulation and recovery in skin disorders. J Clin Invest 116:1150–1158

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Blanpain C, Horsley V, Fuchs E (2007) Epithelial stem cells: turning over new leaves. Cell 128:445–458

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Somerville DA, Noble WC (1973) Micro-colony size of microbes on human skin. J Med Microbiol 6:323

    Article  PubMed  CAS  Google Scholar 

  9. Malcolm SA, Hughes TC (1980) The demonstration of bacteria on and within the stratum corneum using scanning electron microscopy. Br J Dermatol 192(3):267–275

    Article  Google Scholar 

  10. Dominguez-Bello MG et al (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 107:11971–119775

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mueller NT et al (2015) The infant microbiome development: mom matters. Trends Mol Med 21(2):109–117

    Article  PubMed  Google Scholar 

  12. Turnbaugh PJ et al (2009) The Human Microbiome Project. Nature 449:804–810

    Article  CAS  Google Scholar 

  13. Fredricks DN et al (2005) Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353:1899–1911

    Article  PubMed  CAS  Google Scholar 

  14. Marples MJ (1965) The ecology of the human skin. Springfield, Illinois Thomas

  15. Marples MJ (1969) Life on the human skin. Sci Am 220:108–115

    Article  PubMed  CAS  Google Scholar 

  16. Savage DC (1977) Microbial ecology of the intestinal tract. Ann Rev Microbiol 31:107–133

    Article  CAS  Google Scholar 

  17. Grice EA et al (2008) A diversity profile of the human skin microbiota. Genom Res 18:1043–1050

    Article  CAS  Google Scholar 

  18. Gao Z et al (2007) Molecular analysis of the human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A 104(8):2927–2932

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Zhou YJ et al (2013) Biogeography of the ecosystems of the healthy human body. Genom Biol 14:R1

    Article  Google Scholar 

  20. Belkaid Y, Segre JA (2014) Dialogue between skin microbiota and immunity. Science 346(6212):954–959

    Article  PubMed  CAS  Google Scholar 

  21. Findley K, Grice EA (2014) The skin microbiome: a focus on pathogens and their association with skin disease. Plos Pathogens 10(11):31004436

    Article  CAS  Google Scholar 

  22. Tan HH (2003) Antibacterial therapy for acne. Am J Clin Dermatol 4(5):307–314

    Article  PubMed  Google Scholar 

  23. Fitz-Gibbon S et al (2013) Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol 133(9):2153–2160

    Article  CAS  Google Scholar 

  24. Findley K et al (2013) Human skin fungal diversity. Nature 498(7454):367–370

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Gao Z et al (2010) Quantification of major human cutaneous bacterial and fungal populations. J Clin Microbiol 48(10):3575–3581

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Fierer N et al (2008) The influence of sex. handedness, and washing on the diversity of hand surface bacteria. Proc Natl Acad Sci U S A 105:17994–17999

    Article  PubMed  PubMed Central  Google Scholar 

  27. Madison KC (2003) Barrier function of the skin: la raison d’être of the epidermis. J Invest Dermatol 121:231–241

    Article  PubMed  CAS  Google Scholar 

  28. Randhawa M et al (2014) Metabolic signature of sun-exposed skin suggests catabolic pathway overweighs anabolic pathway. Plos One 9(3):e90367

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Zeeuwen P et al (2012) Microbiome dynamics of human epidermis following skin barrier disruption. Gen Bio 13(R101):1–18

    Google Scholar 

  30. Blaser MJ (2014) Missing microbes: how the overuse of antibiotics is fueling our modern plagues. Henry Holt, New York, p 273

    Google Scholar 

  31. Lemon KP et al (2012) Microbiota—target therapies: an ecological perspective. Sci Transl Med 4(137):1–8

    Article  CAS  Google Scholar 

  32. Spinillo A et al (1999) Effect of antibiotic use on the prevalence of symptomatic vulvovaginal candidiasis. Am J Obstet Gynecol 180:14–17

    Article  PubMed  CAS  Google Scholar 

  33. Kelly CP, LaMont JT (2008) Clostridium difficile—more difficult than ever. N Engl J Med 358:1932–1940

    Article  Google Scholar 

  34. Van Nood E et al (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368(5):407–415

    Article  PubMed  CAS  Google Scholar 

  35. Varga M et al (2012) Efficient transfer of antibiotic resistance plasmids by transduction within methicillin-resistant Staphylococcus aureus USA300 clone. FEMS Microbiol Lett 332:146–152

    Article  PubMed  CAS  Google Scholar 

  36. Holland KT, Bojar RA (2002) Cosmetics: what is their influence on the skin microflora. Am J Clin Dermatol 3:445–449

    Article  PubMed  Google Scholar 

  37. Kong HH, Segre JA (2012) Skin microbiome: looking back to move forward. J Invest Dermatol 132(3):933–939

    Article  PubMed  CAS  Google Scholar 

  38. Kong HH et al (2012) Temporal shifts in the skin microbiome with disease flares and treatment in children with atopic dermatitis. Genome Res 22:850–859

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Chen YE, Tsao H (2013) The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol 69(1):143–155

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Costello EK et al (2012) The application of ecological theory towards an understanding of the human microbiome. Science 336(6086):1255–1262

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. van Rensburg JJ, Lin H et al (2015) The human skin microbiome associates with the outcome of and is influenced by bacterial infection. mBio 6(5):e01315-15

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Korte D, Marcelis JH (2014) Platelet concentrates: reducing the risk of transfusion-transmitted bacterial infections. Intern J Clin Trans Med 2:29–37

    Article  Google Scholar 

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Authors and Affiliations

  1. Microbiological Consulting, LLC, 105 Lee Ave., Scarsdale, NY, 10583, USA

    Anthony M. Cundell

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  1. Anthony M. Cundell
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Correspondence to Anthony M. Cundell.

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Cundell, A.M. Microbial Ecology of the Human Skin. Microb Ecol 76, 113–120 (2018). https://doi.org/10.1007/s00248-016-0789-6

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  • DOI: https://doi.org/10.1007/s00248-016-0789-6

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