Abstract
Introduction and hypothesis
To determine the effects of alpha-blocker, extracorporeal magnetic innervations (ExMI) alone and combination treatment on female bladder outlet obstruction (BOO).
Methods
Sixty women with BOO were divided into three groups according to the treatment. After 3 months, the clinical outcomes were evaluated by clinical examination, international prostatic symptom score (IPSS), quality of life (QOL), 3-day voiding diary, uroflowmetry and post-void residual.
Results
At 3 months, symptom improvement was 52.6% in alpha-blocker monotherapy (group I), 50.0% in ExMI monotherapy (group II), and 57.1% in combination therapy (group III). Maximum flow rate increased and total IPSS decreased significantly in all groups (p < 0.05). Storage symptom subscore was more reduced in groups II and III and QOL improved significantly in group III (p < 0.05)
Conclusions
This study demonstrates that both alpha-blocker and ExMI were effective in female BOO, and ExMI may be more effective for improving storage symptoms.
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References
Farrar DJ, Osborne JL, Stephenson TP, Whiteside CG, Weir J, Berry J et al (1975) A urodynamic view of bladder outflow obstruction in the female: factors influencing the results of treatment. Br J Urol 47:815–822
Nitti VW, Tu LM, Gitlin J (1999) Diagnosing bladder outlet obstruction in women. J Urol 161:1535–1540
Groutz A, Blaivas JG, Chaikin DC (2000) Bladder outlet obstruction in women: definition and characteristics. Neurourol Urodyn 19:213–220
Pischedda A, Pirozzi Farina F, Madonia M, Cimino S, Morgia G (2005) Use of alpha1-blockers in female functional bladder neck obstruction. Urol Int 74:256–261
Kessler TM, Studer UE, Burkhard FC (2006) The effect of terazosin on functional bladder outlet obstruction in women: a pilot study. J Urol 176:1487–1492
Kumar A, Mandhani A, Gogoi S, Srivastava A (1999) Management of functional bladder neck obstruction in women: use of alpha-blockers and pediatric resectoscope for bladder neck incision. J Urol 162:2061–2065
Fujishiro T, Takahashi S, Enomoto H, Ugawa Y, Ueno S, Kitamura T (2002) Magnetic stimulation of the sacral roots for the treatment of urinary frequency and urge incontinence: an investigational study and placebo controlled trial. J Urol 168:1036–1039
Kim JW, Kim MJ, Noh JY, Lee HY, Han SW (2005) Extracorporeal pelvic floor magnetic stimulation in children with voiding dysfunction. BJU Int 95:1310–1313
Choe JH, Choo MS, Lee KS (2007) Symptom change in women with overactive bladder after extracorporeal magnetic stimulation: a prospective trial. Int Urogynecol J Pelvic Floor Dysfunct 18:875–880
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U et al (2002) The standardization of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the Interantional Continence Society. Am J Obstet Gynecol 187:116–126
Goldman HB, Zimmern PE (2006) The treatment of female bladder outlet obstruction. BJU Int 98(Suppl 1):17–23
Chassagne S, Bernier PA, Haab F, Roehrborn CG, Reisch JS, Zimmern PE (1998) Proposed cutoff values to define bladder outlet obstruction in women. Urology 51:408–411
Axelrod SL, Blaivas JG (1987) Bladder neck obstruction in women. J Urol 137:497–499
Lemack GE, Zimmern PE (2000) Pressure flow analysis may aid in identifying women with outflow obstruction. J Urol 163:1823–1828
Petrose PE (1997) New ambulatory surgical methods using an anatomical classification of urinary dysfunction improve stress, urge and abnormal emptying. Int Urogynecol J Pelvic Floor Dysfunct 8:270–277
Ek A, Alm P, Andersson KE, Persson CG (1977) Adrenergic and Cholinergic Nerves of the Human Urethra and Urinary Bladder. A histochemical study. Acta Physiol Scand 99:345–352
Yablonsky F, Riffaud JP, Lacolle JY, Dausse JP (1986) Alpha 1- and alpha 2-adrenoceptors in the smooth muscle of male and female rabbit urethra. Eur J Pharmacol 121:1–8
Taki N, Taniguchi T, Okada K, Moriyama N, Muramatsu I (1999) Evidence for predominant mediation of alpha1-adrenoceptor in the tonus of entire urethra of women. J Urol 162:1829–1832
Clarke B (1997) The role of urodynamic assessment in the diagnosis of lower urinary tract disorders. Int Urogynecol J Pelvic Floor Dysfunct 8:196–199
Yamanishi T, Sakakibara R, Uchiyama T, Suda S, Hattori T, Ito H et al (2000) Comparative study of the effects of magnetic versus electrical stimulation on inhibition of detrusor overactivity. Urology 56:777–781
Petros PE, Ulmsten U (1997) Role of the pelvic floor in bladder neck opening and closure: I muscle forces. Int J Urogynecol Pelvic Floor 8:74–80
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Koh, J.S., Kim, S.J., Kim, H.S. et al. Comparison of alpha-blocker, extracorporeal magnetic stimulation alone and in combination in the management of female bladder outlet obstruction. Int Urogynecol J 22, 849–854 (2011). https://doi.org/10.1007/s00192-010-1322-y
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DOI: https://doi.org/10.1007/s00192-010-1322-y