Zusammenfassung
Das diabetische Fußsyndrom ist weltweit eine der bedeutendsten Komplikationen und häufigste Ursache für die Notwendigkeit einer Krankenhausbehandlung bei Patienten mit einem Diabetes mellitus. Die Ätiologie des diabetischen Fußsyndroms ist multifaktoriell und komplex. Die Pathophysiologie der diabetischen Fußläsion mit Polyneuropathie und Angiopathie sowie Wundheilungsstörungen aufgrund des Diabetes steht hier im Vordergrund. Durch geeignete Behandlungsstrategien sowie interdisziplinäre und sektorenübergreifende Strukturen ist es möglich, in Deutschland die im europäischen Vergleich deutlich höheren Amputationsraten zu senken.
Abstract
Diabetic foot ulceration is a serious complication of diabetes mellitus worldwide and the most common cause of hospitalization in diabetic patients. The etiology of diabetic foot ulcerations is complex due to their multifactorial nature. The pathophysiologies of diabetic foot ulceration with polyneuropathy and angiopathy as well as wound-healing impairment in patients with diabetes mellitus are important. Proper adherence to standard treatment strategies and interdisciplinary cooperation can reduce the – compared with European data – noticeable higher rates of major amputations in Germany.
Literatur
Adler A (2001) Risk factors for diabetic neuropathy and foot ulceration. Curr Diab Rep 1:202–207
Ambrosch A, Lehnert H, Lobmann R (2003) Microbiological aspects and antibiotic therapy of diabetic foot infections. Med Klin (Munich) 98:259–265
Ambrosch A, Lobmann R, Pott A, Preissler J (2008) Interleukin-6 concentrations in wound fluids rather than serological markers are useful in assessing bacterial triggers of ulcer inflammation. Int Wound J 5:99–106
Armstrong DG, Jude EB (2002) The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc 92:12–18
Armstrong DG, Lavery LA, Harkless LB (1998) Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation. Diabetes Care 21:855–859
Armstrong DG, Peters EJ (2001) Classification of wounds of the diabetic foot. Curr Diab Rep 1:233–238
Barker AR, Rosson GD, Dellon AL (2006) Wound healing in denervated tissue. Ann Plast Surg 57:339–342
Bentley J, Foster A (2007) Multidisciplinary management of the diabetic foot ulcer. Br J Community Nurs 12:S6, S8, S10
Boulton AJ (2008) The diabetic foot: grand overview, epidemiology and pathogenesis. Diabetes Metab Res Rev 24 (Suppl 1):S3–S6
Boulton AJ, Kirsner RS, Vileikyte L (2004) Clinical practice. Neuropathic diabetic foot ulcers. N Engl J Med 351:48–55
Bus SA, Valk GD, Deursen RW van et al (2008) The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review. Diabetes Metab Res Rev 24 (Suppl 1):S162–S180
Cavanagh PR, Bus SA (2011) Off-loading the diabetic foot for ulcer prevention and healing. Plast Reconstr Surg 127 (Suppl 1):248S–256S
da Silva L, Carvalho E, Cruz MT (2010) Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing. Expert Opin Biol Ther 10:1427–1439
Davis SC, Martinez L, Kirsner R (2006) The diabetic foot: the importance of biofilms and wound bed preparation. Curr Diab Rep 6:439–445
Edmonds ME, Foster AV (2006) Diabetic foot ulcers. BMJ 332:407–410
Edwards J, Stapley S (2010) Debridement of diabetic foot ulcers. Cochrane Database Syst Rev:CD003556
Eneroth M, Houtum WH van (2008) The value of debridement and Vacuum-Assisted Closure (V.A.C.) therapy in diabetic foot ulcers. Diabetes Metab Res Rev 24 (Suppl 1):S76–S80
Fard AS, Esmaelzadeh M, Larijani B (2007) Assessment and treatment of diabetic foot ulcer. Int J Clin Pract 61:1931–1938
Frykberg RG (1998) The team approach in diabetic foot management. Adv Wound Care 11:71–77
Gardner SE, Frantz RA (2008) Wound bioburden and infection-related complications in diabetic foot ulcers. Biol Res Nurs 10:44–53
Gilbey SG (2004) Neuropathy and foot problems in diabetes. Clin Med 4:318–323
Graiani G, Emanueli C, Desortes E et al (2004) Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of type 1 diabetic mice. Diabetologia 47:1047–1054
Hochlenert D, Engels G (2007) Integrated management in patients with diabetic foot syndrome. MMW Fortschr Med 149:41–43
Kalish J, Hamdan A (2009) Management of diabetic foot problems. J Vasc Surg 51:476–486
Kalish J, Hamdan A (2010) Management of diabetic foot problems. J Vasc Surg 51:476–486
Karthikesalingam A, Holt PJ, Moxey P et al (2010) A systematic review of scoring systems for diabetic foot ulcers. Diabet Med 27:544–549
Lawall H, Reike H (2009) Diabetic foot syndrome. Internist (Berl) 50:936–944
Lobmann R, Müller E, Bergmann K et al (2007) The diabetic foot in Germany: Analysis of quality in specialised diabetic wound care centers. Diabetic Foot J 10:68–72
Lobmann R, Müller E, Gröne C, Kersken J (2010) The diabetic foot in Germany: Analysis of quality in specialised diabetic foot care centers. Diabetologia 53 (Suppl 1): 56
Lobmann R, Schultz G, Lehnert H (2005) Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications. Diabetes Care 28:461–471
Lobmann R, Zemlin C, Motzkau M (2006) Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing. J Diabetes Complications 20:329–335
Molines L, Darmon P, Raccah D (2010) Charcot’s foot: newest findings on its pathophysiology, diagnosis and treatment. Diabetes Metab 36:251–255
Morbach S, Müller E, Reike H (2009) Diabetisches Fussyndrom. Diabetol Stoffw 4:157–165
Muangman P, Muffley LA, Anthony JP et al (2004) Nerve growth factor accelerates wound healing in diabetic mice. Wound Repair Regen 12:44–52
Ndip A, Bowling F, Stickings D (2008) The diabetic foot in 2008: an update from the 12th Malvern Diabetic Foot Meeting. Int J Low Extrem Wounds 7:235–238
Rathur HM, Boulton AJ (2007) The neuropathic diabetic foot. Nat Clin Pract Endocrinol Metab 3:14–25
Reike H, Angelkort B (1999) Structures for treatment of patients with diabetic foot syndrome. Internist (Berl) 40:1072–1076
Risse A (2007) The diabetic foot syndrome – an interdisciplinary challenge. Hamostaseologie 27:117–122
Rumenapf G, Dittler S, Morbach S et al (2008) The vascular surgeon’s role in interdisciplinary treatment of diabetic foot syndrome. Chirurgia 79:535–545
Schaper NC, Nabuurs-Franssen MH (2002) The diabetic foot: pathogenesis and clinical evaluation. Semin Vasc Med 2:221–228
Urbancic-Rovan V (2005) Causes of diabetic foot lesions. Lancet 366:1675–1676
van Battum P, Schaper N, Prompers L et al (2011) Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation. Diabet Med 28:199–205
Wallace GF (2007) Debridement of invasive diabetic foot infections. Clin Plast Surg 34:731–734
Wukich DK (2010) Current concepts review: diabetic foot ulcers. Foot Ankle Int 31:460–467
Zimmermann A, Reeps C, Hartl F et al (2009) The diabetic foot. Chirurgia 80:430–436
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Der korrespondierende Autor weist auf folgende Beziehungen hin:
Referententätigkeit und Forschungsförderdung der Firmen Novartis und Bayer.
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Lobmann, R. Das diabetische Fußsyndrom. Internist 52, 539–548 (2011). https://doi.org/10.1007/s00108-010-2733-z
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DOI: https://doi.org/10.1007/s00108-010-2733-z