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Definition, Epidemiologie und ökonomische Aspekte der Sepsis bei Erwachsenen

Sepsis in adult patients – definitions, epidemiology and economic aspects

  • Schwerpunkt: Sepsis
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Zusammenfassung

Die Sepsis ist weltweit eine der Hauptursachen für Morbidität und Mortalität. Allein in Deutschland erkranken pro Jahr 75.000 Einwohner (110 von 100.000) an einer schweren Sepsis bzw. septischem Schock und 79.000 (116 von 100.000) an einer Sepsis. Die Erkrankung geht mit einem hohen Risiko für irreversibles Organversagen mit tödlichem Verlauf einher. Pro Jahr versterben ca. 60.000 Menschen, und bei den Überlebenden findet sich noch über Jahre eine reduzierte Lebensqualität. Aufgrund demographischer Veränderungen ist zukünftig mit einer Zunahme von Inzidenz und Gesamtletalität zu rechnen. Zudem verursacht die Sepsis eine hohe ökonomische Belastung. Eine frühzeitige und umfassende Therapie führt zu einer deutlichen Reduktion der Sterblichkeit. Umfassende Kenntnisse der Epidemiologie, Definitionen und Therapie der Sepsis sind die Voraussetzung für die Eindämmung der sepsisassoziierten Letalität. Ziel dieser Übersicht ist die Präsentation aktueller Definitionen sowie der Epidemiologie und Kosten der Sepsis.

Abstract

Worldwide, sepsis is one of the leading causes of morbidity and mortality. In Germany about 79,000 (116/100,000) suffer from sepsis, and the incidence of severe sepsis and septic shock is about 75,000 cases per year. Patients are at high risk for irreversible organ failure and a lethal course. About 60,000 die from sepsis annually, and survivors have a reduced quality of life. It is presumed that demographic changes will lead to an increased incidence and overall mortality in the future. Additionally sepsis imposes a considerable economic burden to the society. Early and comprehensive treatment significantly improves outcome. An increased knowledge and awareness about the epidemiology, definitions and therapy of sepsis might contribute to the improved outcome. This review aims to present information on current definitions, epidemiology and the economic burden of sepsis.

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  1. Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin, Georg-August-Universität Göttingen, Robert-Koch-Straße 49, 37075, Göttingen, Deutschland

    O. Moerer & M. Quintel

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Moerer, O., Quintel, M. Definition, Epidemiologie und ökonomische Aspekte der Sepsis bei Erwachsenen. Internist 50, 788–798 (2009). https://doi.org/10.1007/s00108-008-2285-7

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