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Grundlagen der topischen Therapie

Basics of topical therapy

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Zusammenfassung

Eine Vielzahl von Dermatosen wird durch eine epikutane Applikation von Wirksubstanzen therapiert. Planung, Konzeption, Durchführung und Überwachung der topischen Therapie zählen zu den Kernkompetenzen der Dermatologie. Dies setzt Grundlagenkenntnisse zur physikochemischen Organisation der Hautschichten, insbesondere des Stratum corneum, sowie zur Interaktion der Wirksubstanz und des Vehikelsystems mit dem Hautorgan voraus. Zudem sind pharmakokinetische Grundkenntnisse und die Besonderheiten für die epikutane Applikation notwendig, um professionell ärztlich handeln zu können.

Abstract

Numerous dermatoses are treated with topically applied substances. Planning, conception, implementation and monitoring of topical therapies are dermatological core competencies. This requires fundamental knowledge about the physicochemical structure of skin layers, especially the stratum corneum, as well as about the interaction of both the active substance and the vehicle system with the skin. Professional treatment also requires basic knowledge about pharmacokinetics and the special features of epicutaneous drug administration.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Wohlrab gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland

    J. Wohlrab

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  1. J. Wohlrab
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Correspondence to J. Wohlrab.

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Wohlrab, J. Grundlagen der topischen Therapie. Hautarzt 65, 169–174 (2014). https://doi.org/10.1007/s00105-013-2654-6

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  • DOI: https://doi.org/10.1007/s00105-013-2654-6

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