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Das komplett künstliche Herz

Total artificial heart

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Zusammenfassung

Hintergrund

Das komplett künstliche Herz [„total artificial heart“ (TAH)] CardioWest™ ist derzeit der einzige, klinisch verfügbare mechanische Herzersatz bei irreversiblem, biventrikulärem Herzversagen.

Fragestellung

Wie lauten die Indikationen und Kontraindikationen für das TAH? Wie gestalten sich die Implantation und postoperative Betreuung?

Material und Methoden

Neben einer Übersicht über die Anwendung des TAH beinhaltet der vorliegende Beitrag eine kurze Vorstellung der zwei Patienten mit TAH-Implantation an unserer Klinik.

Ergebnisse

Der klinische Verlauf, die postoperative Rehabilitation, Komplikationen im System sowie Steuermöglichkeiten werden vorgestellt.

Schlussfolgerungen

Das TAH ist ein Implantat zur effektiven Behandlung von Patienten im irreversiblen kardiogenen Schock als Überbrückung zur Transplantation.

Abstract

Background

To date the CardioWest™ total artificial heart is the only clinically available implantable biventricular mechanical replacement for irreversible cardiac failure.

Objectives

This article presents the indications, contraindications, implantation procedere and postoperative treatment.

Material and methods

In addition to a overview of the applications of the total artificial heart this article gives a brief presentation of the two patients treated in our department with the CardioWest™.

Results

The clinical course, postoperative rehabilitation, device-related complications and control mechanisms are presented.

Conclusion

The total artificial heart is a reliable implant for treating critically ill patients with irreversible cardiogenic shock. A bridge to transplantation is feasible with excellent results.

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Literatur

  1. Antretter H, Laufer G (2001) Surgical techniques for cardiac transplantation. Acta Chir Austriaca 33:17–24

    Article  Google Scholar 

  2. Barnard J, Tsui SSL (2012) The total artificial heart in a cardiac replacement therapy programme. Br J Hosp Med 73:634–639

    Article  Google Scholar 

  3. Bonios MJ, Terrovitis JV, Drakos SG et al (2012) Comparison of three different regimens of intermittent inotrope infusions for end stage heart failure. Int J Cardiol 159:225–229

    Article  PubMed  Google Scholar 

  4. Copeland JG (2013) SynCardia total artificial heart. Update and future. Tex Heart Inst J 40:587–588

    PubMed Central  PubMed  Google Scholar 

  5. Copeland JG, Arabia FA, Tsau PH et al (2003) Total artificial hearts: bridge to transplantation. Cardiol Clin 21:105–117

    Article  Google Scholar 

  6. Copeland JG, Smith RG, Arabia FA et al (2004) Cardiac replacement with a total artificial heart as a bridge to transplantation. N Eng J Med 351:859–867

    Article  CAS  Google Scholar 

  7. El-Banayosy A, Arusoglu L, Morshuis M et al (2005) CardioWest total artificial heart: Bad Oeynhausen experience. Ann Thorac Surg 80:548–552

    Article  PubMed  Google Scholar 

  8. Fitzpatrick JR 3rd, Frederick JR, Hsu VM et al (2008) Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support. J Heart Lung Transplant 27:1286–1292

    Article  PubMed Central  PubMed  Google Scholar 

  9. Hoefer D, Poelzl G, Kilo J et al (2005) Early detection and successful therapy of fulminant chlamydia pneumoniae myocarditis. ASAIO J 51:480–481

    Article  PubMed  Google Scholar 

  10. Holman WL (2012) Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS): what have we learned and what will we learn? Circulation 126:1401–1406

    Article  PubMed  Google Scholar 

  11. Jessup M, Brozena S (2003) Heart failure. N Eng J Med 348:2007–2018

    Article  Google Scholar 

  12. Kirklin JK, Naftel DC, Pagani FD et al (2012) Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? J Thorac Cardiovasc Surg 144:584–603

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kirklin JK, Naftel DC, Kormos RL et al (2012) The fourth INTERMACS annual report: 4000 implants and counting. J Heart Lung Transplant 31:117–126

    Article  PubMed  Google Scholar 

  14. Kirklin JK, Naftel DC, Pagani FD et al (2014) Sixth INTERMACS annual report: a 10,000-patient database. J Heart Lung Transplant 33:555–564

    Article  PubMed  Google Scholar 

  15. Poelzl G, Frick M, Antretter H et al (2006) Interventional and medical treatment of acute heart failure due to inflammation. Herz 31:1761–1766

    Article  Google Scholar 

  16. Puehler T, Ensminger S, Schoenbrodt M et al (2014) Mechanical circulatory support devices as a destination therapy – current evidence. Ann Cardiothorac Surg 3:513–524

    PubMed Central  PubMed  Google Scholar 

  17. Roussel JC, Senage T, Baron O et al (2009) CardioWest (Jarvik) total artificial heart: a single center experience with 42 patients. Ann Thorac Surg 87:124–130

    Article  PubMed  Google Scholar 

  18. Stehlik J, Edwards LB, Kucheryavaya AY et al (2011) The registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant Report – 2011. J Heart Lung Transplant 30:1078–1094

    Article  PubMed  Google Scholar 

  19. Szefner J, Cabrol C (1993) Control and treatment of hemostasis in patients with a total artificial heart: the experience at La Pitie. In: Piffare R (Hrsg) Anticoagulation, hemostasis and blood preservation in cardiovascular surgery. Hanley and Belfus, Philadelphia, S 237–264

  20. Takeda K, Takayama H, Kalesan B et al (2015) Outcome of cardiac transplantation in patients requiring prolonged continuous-flow left ventricular assist device support. J Heart Lung Transplant 34:89–99

    Article  PubMed  Google Scholar 

  21. Tarzia V, Buratto E, Gallo M et al (2014) Surgical implantation of the CardioWest Total Artificial Heart. Ann Cardiothorac Surg 3:624–625

    PubMed Central  PubMed  Google Scholar 

  22. Torregrossa G, Anyanwu A, Zucchetta F, Gerosa G (2014) SynCardia: the total artificial heart. Ann Cardiothorac Surg 3:612–620

    PubMed Central  PubMed  Google Scholar 

  23. Zimmerman H, Coehlo-Anderson R, Slepian M et al (2010) Device malfunction of the CardioWest total artificial heart secondary to catheter entrapment of the tricuspid valve. ASAIO J 56:481–482

    Article  PubMed  Google Scholar 

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Correspondence to H. Antretter.

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Interessenkonflikt

H. Antretter, J. Dumfarth und D. Höfer geben an, dass kein Interessenkonflikt besteht.

Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben. Im Falle von nicht mündigen Patienten liegt die Einwilligung eines Erziehungsberechtigen oder des gesetzlich bestellten Betreuers vor.

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A. Geppert, Wien

G. Heinz, Wien

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Antretter, H., Dumfarth, J. & Höfer, D. Das komplett künstliche Herz. Med Klin Intensivmed Notfmed 110, 431–437 (2015). https://doi.org/10.1007/s00063-015-0060-9

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  • DOI: https://doi.org/10.1007/s00063-015-0060-9

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