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Estrogen and androgen dynamics in liver disease

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Abstract

Constant infusions of 3H-androgen/14C-estrogen were given to 18 men with increased serum bilirubin concentrations and biopsy proven hepatic cirrhosis. From data obtained from the infusions and the radioimmunoassay of circulating endogenous steroid levels metabolic clearance rates (MCR), blood production rates (PB), aromatization rates (fraction of androgen infused into and measured as estrogen in blood; [p] And, EstBB ) and conversion ratios (ratio of concentration of radioactivity of infused precursor to product steroid in blood; CRPREC,PROD) were calculated.These data were compared to normal data obtained from similar studies in a group of normal men similar in age and weight. The mean concentrations of testosterone (T), and dihydrotestoste-rone (DHT), were decreased but those of estrone (E1) and estradiol (E2) were increased, and the concentration of androstenedione, (A), was similar compared to the normal values. Compared to the values in normal men the mean MCR of T was decreased those of A and E2 were normal, and that of E1 was slightly increased. However, the PB’s of both estrogens were increased while that of A was normal T was decreased. The increase in the PB’s of the estrogens could be explained on the basis of a marked increase in [p] And, EstBB probably due to a shift in blood flow from the liver to peripheral tissue. These findings were noted in men with alcoholic cirrhosis as well as cardiac cirrhosis and in 1 subject with infectious hepatitis. Abnormalities in steroid metabolism occur in men with several types of liver disease and are not limited to those with alcoholic liver disease.

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References

  1. Lloyd C.W., Williams R.H. Endocrine changes associated with Laennec’s cirrhosis of the liver. Am. J. Med. 4: 315, 1948.

    Article  PubMed  CAS  Google Scholar 

  2. Barr R.W., Sommers S.C. Endocrine abnormalities accompanying hepatic cirrhosis and hepatoma. J. Clin. Endocrinol. Metab. 17: 1017, 1957.

    Article  PubMed  CAS  Google Scholar 

  3. Long R.G. Endocrine aspects of liver disease. Br. Med. J. 1: 225, 1980.

    Article  Google Scholar 

  4. Cameron C.B. Urinary excretion of oestrone, oestradiol-17β and oestriol in patients with chronic liver damage. J. Endocrinol. 15: 199, 1957.

    Article  PubMed  CAS  Google Scholar 

  5. Gordon G.G., Olivo J., Rafii F., Southren A.L. Conversion of androgens to estrogens in cirrhosis of the liver. J. Clin. Endocrinol. Metab. 40: 1018, 1975.

    Article  PubMed  CAS  Google Scholar 

  6. Bakers H.W.G., Burger H.G., deKrester D.M., Dulmanis A., Hudson B., O’Connor S., Paulsen C.A., Purcell N., Rennie G.C., Seah C.S., Taft H.P., Wang C. A study of the endocrine manifestations of hepatic cirrhosis. Q.J. Med. 45: 145, 1976.

    Google Scholar 

  7. Chopra I.J., Tulchinsky D., Greenway F.L. Estrogen-androgen imbalance in hepatic cirrhosis. Ann. Intern. Med. 79: 198, 1973.

    Article  PubMed  CAS  Google Scholar 

  8. Kley H.K., Nieschlag E., Wiegelmann W., Solbach H.C., Krüskemper H.L. Steroid hormones and their binding in plasma of male patients with fatty liver, chronic hepatitis and liver cirrhosis. Acta Endocrinol. (Kbh.) 72: 275, 1975.

    Google Scholar 

  9. Olivo J., Gordon G.G., Rafii F., Louthren A.L. Estrogen metabolism in hyperthyroidism and in cirrhosis of the liver. Steroids 26: 47, 1975.

    Article  PubMed  CAS  Google Scholar 

  10. Longcope C., Layne D.S., Tait J.F. Metabolic clearance rates and interconversions of estrone and 17β-estradiol in normal males and females. J. Clin. Invest. 47: 93, 1968.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  11. Longcope C., Kato T., Horton R. Conversion of blood androgens to estrogens in normal adult men and women. J.Clin. Invest. 48: 2191, 1969.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  12. Franz C., Longcope C. Androgen and estrogen metabolism in male rhesus monkeys. Endocrinology 105: 869, 1979.

    Article  PubMed  CAS  Google Scholar 

  13. Ridgway E.C., Maloof F., Longcope C. Androgen and oestrogen dynamics in hyperthyroidism. J. Endocrinol. 95: 105, 1982.

    Article  PubMed  CAS  Google Scholar 

  14. Longcope C., Pratt J.H., Schneider S.H., Fineberg S.E. In vivo studies on the metabolism of estrogens by muscle and adipose tissue of normal males. J. Clin. Endocrinol. Metab. 43: 1134, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Ridgway E.C., Longcope C., Maloof F. Metabolic clearance and blood production rates of estradiol in hyperthyroidism. J. Clin. Endocrinol. Metab. 41: 491, 1975.

    Article  PubMed  CAS  Google Scholar 

  16. Pratt J.H., Longcope C. Effect of adrenocorticotropin on production rates and metabolic clearance rates of testosterone and estradiol. J. Clin..Endocrinol. Metab. 47: 307, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Baird D.T., Horton R., Longcope C., Tait J.F. Steroid prehormones. Perspect. Biol. Med. 11: 385, 1974.

    Google Scholar 

  18. Ito T., Horton R. The source of plasma dihydrotestosterone in man. J. Clin. Invest. 50: 1621, 1971.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  19. Bennett H.S., Baggenstoss A.H., Butt H.R. The testis, breast and prostate of men who die of cirrhosis of the liver. Arn. J. Clin. Pathol. 20: 814, 1950.

    CAS  Google Scholar 

  20. Wilson J.D., Gloyna R.E. The intranuclear metabolism of testosterone in the accessory organs of reproduction. Recent Prog. Horm. Res. 26: 309, 1970.

    PubMed  CAS  Google Scholar 

  21. Imperato-McGinley J., Peterson R.E. Male pseudohermaphroditism: the complexities of male phenotypic development. Am. J. Med. 61: 251, 1976.

    Article  PubMed  CAS  Google Scholar 

  22. Fischer A. Dynamics of the circulation in the liver. In: Rouiller CH. (Ed.), The liver. Academic Press, New York, 1963, vol. 1, p. 329.

    Chapter  Google Scholar 

  23. Wade O.L., Bishop J.M. Cardiac output and regional blood flow. Blackwell Scientific Publications, Oxford, 1962, p. 185.

    Google Scholar 

  24. Anderson D.C. Sex-hormone-binding globulin. Clin. Endocrinol (Oxf.) 3: 69, 1974.

    Article  CAS  Google Scholar 

  25. Zumoff B., Bradlow H.L., Gallagher T.F., Hellman L. Cortisol metabolism in cirrhosis. J. Clin. Invest. 46: 1735, 1967.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  26. Longcope C., Sato K., McKay C., Horton R. Aromatization of androgens by human splanchnic organs in vivo. Prog. 65th Annual Meeting Endocrine Society, 1983 (Abstract no. 662).

    Google Scholar 

  27. Longcope C., Biliiar R., Takaoka Y., Reddy P.S., Richards D., Little B. Tissue sites of aromatization in the female monkey. Endocrinology 113: 1679, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Longcope C., Pratt J.H., Schneider S.H., Fineberg S.E. Aromatization of androgens by muscle and adipose tissue in vivo. J. Clin. Endocrinol. Metab. 46: 146, 1978.

    Article  PubMed  CAS  Google Scholar 

  29. Schweikert H.U., Milewich L., Wilson J.D. Aromatization of androstenedione by cultured human fibroblasts. J. Clin. Endocrinol. Metab. 43: 785, 1976.

    Article  PubMed  CAS  Google Scholar 

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All infusions were carried out in the Cinical Research Center of Boston City Hospital, which is supported by a Grant (RR-553) from the General Clinical Research Center’s Program of the Division of Research Resources, N.I.H, This work was supported by Grant No, HD-15443 from NICHHD and AM-16896 from the NIAMDD.

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Longcope, C., Pratt, J.H., Schneider, S. et al. Estrogen and androgen dynamics in liver disease. J Endocrinol Invest 7, 629–634 (1984). https://doi.org/10.1007/BF03349497

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