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Association of HLA-DRB1, DQB1 alleles with chronic urticaria

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Summary

In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1* 12. * 0901 (RR=3.11, χ2=7.579,P=0.006; RR=2.47, χ2=5.684,P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, χ2=6.683,P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.

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Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, 430022, Wuhan, China

    Chen Jing, Tan Zhijian, Li Liawen & Xiong Ping

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  1. Chen Jing
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  2. Tan Zhijian
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  3. Li Liawen
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  4. Xiong Ping
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CHEN Jing, female, born in 1977, Docforial Cardidate

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Jing, C., Zhijian, T., Liawen, L. et al. Association of HLA-DRB1, DQB1 alleles with chronic urticaria. Current Medical Science 25, 354–356 (2005). https://doi.org/10.1007/BF02828166

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  • DOI: https://doi.org/10.1007/BF02828166

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