Abstract
The genotoxicity of quinolone antibiotics (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin) was studied on the selected mutantE. coli strain PQ37 (SOS chromotest). The genotoxicity was expressed by SOS-inducing potential (SOSIP) values. The highest SOSIP values were found with ciprofloxacin (SOSIP=1967 δIF/nmol), the lowest value was observed with nalidixic acid (SOSIP=0.3 ΔIF/nmol). Similar results were also found with the biosynthesis of nucleic acids, as indicated by incorporation of14C-adenine into TCA-insoluble fractions ofS. typhimurium cells (ciprofloxacin IC50=0.39, nalidixic acid IC50=400). DNA-damaging effects were tested in the absence of an exogenous metabolizing system.
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Majtánová, L., Majtán, V. Quinolone effects in the SOS chromotest and in the synthesis of biomacromolecules. Folia Microbiol 41, 233–236 (1996). https://doi.org/10.1007/BF02814622
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DOI: https://doi.org/10.1007/BF02814622