Summary
Rheumatoid factor (RF) is known to be present very frequently in HB virus carriers. When RF was assayed in 140 asymptomatic carriers by agglutination method, 20.0% were found to be positive, whereas 2.7% in the controls (p<0.01). ELISA for detection of RF isotypes showed RF in carriers to be almost IgMRF only. IgMRF showed a tendency to react more readily to human IgG rather than to rabbit IgG. The incidence of IgMRF positivity was higher among anti-HBe antibody-positive carriers than among anti-HBe antibody negative ones, but the difference between the two populations was not significant. However, the incidence of IgMRF positivity in the group showing hepatic dysfunctions was found to be significantly higher than in the group with normal hepatic functions.
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Dresner, E., Trombly, P. Latex-fixation reaction in non-rheumatic diseases. N Engl J Med 1959, 261, 981–988.
Howell, D.S., Malcolm, J.M., Pike, R. FII agglutinating factors in serums of patients with nonrheumatic diseases. Am J Med 1960, 29, 662–671.
Cohen, E., Shimaoka, K., Hermes, P. Latex agglutination reaction in nonrheumatic diseases. Lancet 1960, i, 1352–1353.
Bonomo, L., LoSpalluto, J., Ziff, M. Anti-gamma globulin factors in liver diseases. Arthritis Rheum 1963, 6, 104–114.
Alwater, E.C., Jacox, R.F., Latex-fixation test in patients with liver diseases. Ann Intern Med 1963, 58, 419–426.
Bouchier, I.A.D., Rhodes, K., Sherlock, S., Serologic abnormalities in patients with liver diseases. Br Med J 1964, 1 592–594.
Risemberg, A., De Gomez, A.G., Rife, U. Agglutinating factor in serum of patients with viral hepatitis. Ann Rheum Dis 1969, 28, 428–430.
Sherlock, S. Viral hepatitis. In: Diseases of the liver and biliary system. Blackwell Scientific Publications, Oxford-London-Edinburgh-Boston-Melbourne, 1989, 301–338.
Furuta, S., Nagata, A., Kiyosawa, K., Yamamura, S., Sodeyama, S., Oda, M., Mayumi, M. e/anti-e, rheumatoid factor, and liver diseases. Lancet 1977, 13, 353.
Tedder, R.S., Briggs, M. Anti-e and rheumatoid factor activity in hepatitis B. Lancet 1977, 11, 1262–1263.
Nishimaki, T., Watanabe, S., Yoshida, H., Kasukawa, R. Immunoglobulin class of rheumatoid factors detected by enzyme-linked immunosorbent assay Clin Rheumatol 1983, 2, 145–151.
Bamptom, J.L.M., Cawston, T.A., Kyle, M.V., Hazleman, B.L. Measurement of rheumatoid factors by an enzyme-linked immunosorbent assay (ELISA) and comparison with other methods. Ann Rheum Dis 1985, 44, 13–19.
Ziegenfuss, J.F., Miller, F., Rassman, D. Rheumatoid factor and Australia antigen. N Engl J Med 1971, 284, 1104.
State, I., Rungan V., Voiculescu, M., State, D., Rheumatoid factor and Australia antigen in acute and chronic hepatitis. Rev Rum Med Int 1973, 10, 29–36.
Dudley, F.J., O'hea, M.J., Sherlock, S. Serum autoantibodies in hepatitis associated antigen (HAA) positive patients. Clin Exp Immunol 1973, 13, 367–372.
Hoofnagel, J.H., Markenson, J.A., Daniels, C.A., Gerety, R.J., Notkins, A.L., Barker, L.F. The lack of association between rheumatoid factor and hepatitis B antigen. Am J Med Science 1973, 268, 23–29.
Dragosics, B., Ferenci, P., Hitchman, E., Denk, H. Long-term follow-up study of asymptomatic HBsAg-positive voluntary blood donors in Austria: A clinical and histologic evaluation of 242 cases. Hepatology 1987, 7, 302–306.
Anderson-Visona, K., Villarejos, V.M. Identity of antibody to hepatitis B e/1 antigen as an atypical rheumatoid factor. J Infec Dis 1980, 14, 603–608.
Baba, K., Ikuise, Aihara, S., Kishimoto, S., Tsuda, F., Tachibana, K., Miyakawa, Y., Mayumi, M. Small and large forms of hepatitis B e antigen in serum: Determination by two-site sandwich radioimmunoassay with monoclonal antibodies. Clin Exp Immunol 1986, 64, 295–301.
Yamada, E., Ishida, N., Ohori, H. Comparison of the antigenecity and protein composition of hepatitis B virus e antigen subtypes HBeAg/1 and HBeAg/2. J Gen Virol 1983, 64, 895–903.
Theofilopoulos, A.N., Wilson, G.B., Dixon, F.J. The raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 1976, 57, 169–187.
Leyva, A., Bernal, M.C., Piedrola, G., Maroto, M.C. A study of the evolution of specific and non-specific immune complexes in acute hepatitis B and chronic hepatitis. J Med Microbiol 1988, 26, 237–239.
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Watanabe, K., Ohkubo, Y., Funahashi, Y. et al. An investigation on rheumatoid factor of different immunoglobulin classes in hepatitis B virus crriers. Clin Rheumatol 10, 31–37 (1991). https://doi.org/10.1007/BF02208030
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DOI: https://doi.org/10.1007/BF02208030