Abstract
5-Fluouracil was used to inhibit experimental intraocular proliferation in rabbit eyes, produced by homologe fibroblast implantation. Two different concentrations were used, 1 and 5 mg in a single intravitreal injection. The eyes were followed up over 4 weeks. Proliferation and resulting traction detachment was reduced from 75% to 30% in the 1-mg 5-fluouracil group. In addition, we observed retinal and vascular changes in a considerable number of eyes treated with 1 mg and much more pronounced alterations in most of the eyes treated with 5 mg fluouracil.
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Binder, S., Riss, B., Skorpik, C. et al. Inhibition of experimental intraocular proliferation with intravitreal 5-fluouracil. Graefe's Arch Clin Exp Ophthalmol 221, 126–129 (1983). https://doi.org/10.1007/BF02133851
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DOI: https://doi.org/10.1007/BF02133851