Abstract
In 30 patients with chronic renal insufficiency (16 non-dialysed and 14 on dialysis) serum calcium, phosphate and alkaline phosphatase were determined and, in a crest biopsy specimen, morphometric determinations of bone qualities were calculated. A positive correlation was established between serum alkaline phosphatase, the osteoblast surface and the active resorption surface in both dialysed and non-dialysed patients. A positive correlation was also established between the osteoblast surface and the active resorption. In the non-dialysed patients a negative correlation was established between serum calcium and the osteoid surface.
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Avioli, L. V., Birge, S., Lee, S. W., Slatopolsky, E.: The metabolism of vitamin D3-3H in chronic renal failure. J. clin. Invest.47, 2239 (1968)
Bijvoet, O. L. M.: The assessment of phosphate reabsorption. Clin. chim. Acta26, 15 (1969)
Bricker, N. S., Slatopolsky, E., Reiss, E., Avioli, L. V.: Calcium, phosphorus and bone in renal disease and transplantation. Arch. intern. Med.123, 543 (1969)
Curtis, J. R., Wardener, H. E. de, Gower, P. E., Eastwood, J. B.: The use of calcium carbonat and phosphat without vitamin D in the management of renal osteodystrophy. In: Europ. Dialysis Transplant Ass, p. 19, J. Congress, Barcelone 1970
Duursma, S. A., Visser, W. J., Njio, L.: A quantitative histological study of bone in 30 patients with renal insufficiency. Calcif. Tiss. Res.9, 216 (1972)
Duursma, S. A., Visser, W. J., Zoeren, M. v., Korver, M. F.: A bone biopsy procedure. Calcif. Tiss. Res.4, 269 (1969)
Fraser, D. R., Kodicek, E.: Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature (Lond.)228, 764 (1970)
Garner, A., Ball, J.: Quantitative observations on mineralised and unmineralised bone in chronic renal azotaemia and intestinal malabsorption syndrome. J. Path. Bact.91, 545 (1966)
Harris, W. H., Heaney, R. P.: Skeletal renewal and metabolic bone disease (continued). New Engl. J. Med.280, 253 (1969)
Kleeman, C. R., Massry, S. G., Coburn, J. W., Popovtzer, M. M.: Renal osteodystrophy, soft tissue calcification and disturbed divalent ion metabolism in chronic renal failure. Arch. intern. Med.124, 262 (1969)
Kuhlencordt, F., Bauditz, W., Lozano-Tonkin, C., Kruse, H. P., Augustin, H. J., Rehpenning, W., Bartelheimer, H.: Osteopathien und Calcium-Phosphat-Stoffwechsel bei chronischer Hämodialyse. Klin. Wschr.49, 134 (1971)
Liu, S. H., Chu, H. J.: Studies of calcium and phosphorus metabolism with special reference to pathogenesis and effects of dihydrotachysterol (A.T. 10) and iron. Medicine (Baltimore)22, 103 (1943)
Merz, W. A.: Die Streckenmessung an gerichteten Strukturen im Mikroskop und ihre Anwendung zur Bestimmung von Oberflächen-Volumen-Relationen im Knochengewebe. Dissertation, Basel 1967
Nguyen, V. v., Jowsey, J.: Bone metabolism. The acute effects of hormones, vitamin D3, and acidosis during in vivo perfusion of adult dog forelimbs. J. Bone Jt. Surg.52, 1041 (1970)
Ogg, C. S.: The intestinal absorption of47Ca by patients in chronic renal failure. Clin. Sci.34, 467 (1968)
Potts, J. T., Reitz, R. E., Deftos, L. J., Kaye, M. B., Richardson, J. A., Buckle, R. M., Aurbach, G. D.: Secondary hyperparathyroidism in chronic renal disease. Arch. intern. Med.124, 408 (1969)
Schäfer, K., Schäfer, P., Koeppe, P., Opitz, A., Höffler, D.: Untersuchungen zur Frage der urämische Osteopathie. Dtsch. med. Wschr.93, 1018 (1968)
Schenk, R. K.: Zur histologischen Verarbeitung von unentkalkten Knochen. Acta anat. (Basel)60, 3 (1965)
Schenk, R. K., Merz, W. A.: Histologisch-morphometrische Untersuchungen über Altersatrophie und senile Osteoporose in der Spongiosa des Beckenkammes. Dtsch. med. Wschr.94, 206 (1969)
Stanbury, S. W.: Bone disease in uremia. Amer. J. Med.44, 714 (1968)
Stanbury, S. W., Lumb, G. A., Mawer, E. B.: Osteodystrophy developing spontaneously in the course of chronic renal failure. Arch. intern. Med.124, 274 (1969)
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Duursma, S.A., Visser, W.J., Mees, E.J.D. et al. Serum calcium, phosphate and alkaline phosphatase and morphometric bone examinations in 30 patients with renal insufficiency. Calc. Tis Res. 16, 129–138 (1974). https://doi.org/10.1007/BF02008218
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DOI: https://doi.org/10.1007/BF02008218