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Summary

A clinicopathologic analysis of 103 liposarcomas from the lower extremity and the retroperitoneum was presented. The tumors were divided according to their histologic pattern into four groups: liposarcomas of the myxoid cell, round cell, well-differentiated, and pleomorphic types. The various histologic groups differed considerably in location, age distribution, and clinical behavior. The myxoid and round cell types were most common in the lower extremity, while the majority of well-differentiated and pleomorphic liposarcomas originated in the retroperitoneum. The median age of patients with myxoid and round cell tumors was also about 11 years less than that of patients with well-differentiated and pleomorphic liposarcomas.

Follow-up information obtained in 91 of the patients revealed that all liposarcomas irrespective of type had recurred in more than 50% of the patients. Yet, the 5-year survival rates of the myxoid and well-differentiated types were almost four times those of the round cell and pleomorphic types, and the over-all survival rates were considerably better in the liposarcomas of the lower extremity than in those of the retroperitoneum.

Zusammenfassung

Der Arbeit liegen 103 Liposarkome der unteren Gliedmaßen und des Retroperitonealraums zugrunde. Nach dem histologischen Struktur- und Zellbild werden 4 Typen unterschieden: der myxoide, der Rundzell-, der hochdifferenzierte und der pleomorphe Typus. Die histologischen Varianten zeigen in bezug auf Lokalisation, Alter des Patienten und klinischem Verhalten beträchtliche Unterschiede. Der myxoide und Rundzelltypus kommt besonders an den unteren Gliedmaßen vor, während die Mehrzahl der hochdifferenzierten und pleomorphen Sarkome vom Retroperitonealraum ihren Ausgang nehmen. Das mittlere Lebensalter der Patienten mit myxoiden und Rundzell-Liposarkomen liegt 11 Jahre tiefer als dasjenige der Patienten mit hochdifferenzierten und pleomorphen Liposarkomen. Die Katamnesen von 91 Patienten zeigen, daß Liposarkome, unabhängig vom histologischen Typus, in 50% der Fälle rezidivieren. Die 5-Jahresüberlebensdauer ist bei dem myxoiden und hochdifferenzierten Typus viermal höher als bei dem Rundzell- und pleomorphen Typus. Gesamthaft liegen die Überlebenszeiten der Träger der Liposarkome der unteren Gliedmaßen erheblich über denjenigen des Retroperitonealraumes.

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Enzinger, F.M., Winslow, D.J. Liposarcoma. Virchows Arch. path Anat. 335, 367–388 (1962). https://doi.org/10.1007/BF00957030

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