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Ischemia-selectivity: a new concept of cardioprotection by calcium antagonists

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References

  1. Baumgart D, Ehring T, Kowallik P, Guth BD, Krajcar M, Heusch G (1993) The impact of α-adrenergic coronary vasoconstriction on the transmural myocardial blood flow distribution during humoral and neuronal adrenergic activation. Circ Res 73:869–886

    Google Scholar 

  2. Baumgart D, Ehring T, Krajcar M, Heusch G (1993) A proischemic effect of nisoldipine: Relation to a decrease in perfusion pressure and comparison to dipyridamole. Cardiovasc Res 27:1254–1259

    Google Scholar 

  3. Bean BP (1984) Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state. Proc Natl Acad Sci 81:6388–6392

    Google Scholar 

  4. Ehring T, Böhm M, Heusch G (1992) The calcium antagonist nisoldipine improves the functional recovery of reperfused myocardium only when given before ischemia. J Cardiovasc Pharmacol 20:63–74

    Google Scholar 

  5. Ehring T, Heusch G (1990) Felodipine prevents the poststenotic myocardial ischemia induced by α2-adrenergic coronary constriction. Cardiovasc Drugs Ther 4:443–449

    Google Scholar 

  6. Godfraind T, Miller R, Wibo M (1986) Calcium antagonism and calcium entry blockade. Pharmacol Rev 38:321–416

    Google Scholar 

  7. Heusch G (1990) α-adrenergic mechanisms in myocardial ischemia. Circulation 81:1–13

    Google Scholar 

  8. Heusch G (1992) Myocardial stunning: a role for calcium antagonists during ischaemia? Cardiovasc Res 26: 14–19

    Google Scholar 

  9. Heusch G, Deussen A (1983) The effects of cardiac sympathetic nerve stimulation on the perfusion of stenotic coronary arteries in the dog. Circ Res 53:8–15

    Google Scholar 

  10. Heusch G, Deussen A (1984) Nifedipine prevents sympathetic vasoconstriction distal to severe coronary stenoses. J Cardiovasc Pharmacol 6:378–383

    Google Scholar 

  11. Heusch G, Deussen A, Schipke J, Thämer V (1986) Adenosine, dipyridamole and isosorbiddinitrate are ineffective to prevent the sympathetic initiation of poststenotic myocardial ischemia. Drug Res 36:1045–1048

    Google Scholar 

  12. Heusch G, Guth BD (1990) Coronary vasomotor tone in myocardial ischemia. In: Heusch G (ed) Pathophysiology and rational pharmacotherapy of myocardial ischemia; Steinkopff, Springer, Darmstadt, New York, pp 199–216

    Google Scholar 

  13. Heusch G, Guth BD, Seitelberger R, Ross Jr. J (1987) Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine. Circulation 75:482–490

    Google Scholar 

  14. Indolfi C, Ross Jr. J (1993) The role of heart rate in myocardial ischemia and infarction: Implications of myocardial perfusion-contraction matching. Prog Cardiovasc Dis 36:61–74

    Google Scholar 

  15. Kaski JC, Maseri A (1990) Clinical significance of coronary vasomotor tone in myocardial ischemia. In: Heusch G (ed) Pathophysiology and rational pharmacotherapy of myocardial ischemia; Steinkopff, Springer, Darmstadt, New York, pp 217–229

    Google Scholar 

  16. Maseri A, Chierchia S (1982) Coronary artery spasm: demonstration, definition, diagnostic, and consequences. Prog Cardiovasc Dis 25:169–192

    Google Scholar 

  17. Nayler WG (1990) The endothelins. Springer, Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona

    Google Scholar 

  18. Opie LH (1990) Clinical use of calcium channel antagonist drugs. Kluwer Academic Publishers, Boston, Dordrecht, London

    Google Scholar 

  19. Opie LH (1992) Should calcium antagonists be used after myocardial infarction? Ischemia selectivity versus vascular selectivity. Cardiovasc Drugs Ther 6:19–24

    Google Scholar 

  20. Przyklenk K, Ghafari GB, Eitzman DT, Kloner RA (1989) Nifedipine administered after reperfusion ablates systolic contractile dysfunction of postischemic “stunned” myocardium. J Am Coll Cardiol 13:1176–1183

    Google Scholar 

  21. Rafflenbeul W, Lichtlen PR (1982) Zum Konzept der “dynamischen” Koronarstenose. Z Kardiol 71:439–444

    Google Scholar 

  22. Rudolph W, Reiniger G, Dirschinger J, Kraus F (1990) Treatment of myocardial ischemia with nitrates. In: Heusch G (ed) Pathophysiology and rational pharmacotherapy of myocardial ischemia; Steinkopff-Springer, Darmstadt-New York, pp 275–294

    Google Scholar 

  23. Sanguinetti MC, Kass RS (1984) Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 55:336–348

    Google Scholar 

  24. Thadani U, Zellner SR, Glasser S, Bittar N, Montoro R, Miller AB, Chaitman B, Schulman P, Stahl A, DiBianco R, Bray J, Means WE, Morledge J (1991) Double-blind, dose-response, placebo-controlled multicenter study of nisoldipine. A new second-generation calcium channel blocker in angina pectoris. Circulation 84:2398–2408

    Google Scholar 

  25. Veniant M, Clozel JP, Hess P, Wolfgang R (1991) Hemodynamic profile of Ro 40-5967 in conscious rats: Comparison with diltiazem, verapamil, and amlodipine. J Cardiovasc Pharmacol 18 (suppl 10): S55-S58

    Google Scholar 

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Professor Lionel H. Opie, Cape Town, kindly reviewed this article.

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Heusch, G. Ischemia-selectivity: a new concept of cardioprotection by calcium antagonists. Basic Res Cardiol 89, 2–5 (1994). https://doi.org/10.1007/BF00788672

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