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Frequency-dependence of early auditory evoked responses in the guinea pig

Die Frequenzspezifität früher akustisch evozierter Reizantworten beim Meerschweinchen

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Archives of oto-rhino-laryngology Aims and scope Submit manuscript

Zusammenfassung

Die Frequenzspezifität der über Oberflächenelektroden abzuleitenden Hirnstammpotentiale und Frequenzfolgepotentiale sowie der am runden Fenster aufzuzeichnenden Potentiale wurde für den Frequenzbereich von 500 Hz bis 15 kHz beim Meerschweinchen untersucht. Aufgrund der Antwortcharakteristika ließen sich die Hirnstammantworten und Frequenzfolgepotentiale bei Frequenzen unter 2 kHz für Reizintensitäten in Schwellennähe auf die Erregung apikaler Bereiche der Basilarmembran zurückführen. Gleiches traf für die am runden Fenster abgeleiteten Potentiale zu. Der Vergleich der Antworten über Oberflächenelektroden mit den am runden Fenster aufgezeichneten Potentialen zeigte Übereinstimmung des breit angelegten Potentials PI der Hirnstammantworten im Tieftonbereich mit dem Summenaktionspotential, und Entsprechung der Frequenzfolgepotentiale mit phasenbezogenen Antworten des N. acusticus auf.

Summary

Neural auditory responses in the guinea pig, monitored by surface electrodes (brain stem potentials and frequency-following responses) and by electrodes at the round window, were analyzed for evidence of frequency dependence in the range from 500 Hz to 15 kHz. The characteristics of the brain stem potentials and frequency-following responses with stimuli near threshold intensity for frequencies below 2 kHz indicate that this activity derives from the excitation of apical regions of the basilar membrane. The same interpretation applies to the potentials recorded at the round window. Comparison of the responses seen with surface electrodes and those appearing at the round window reveals that the broad potential PI of the brain stem response to low-frequency stimuli corresponds to the compound action potential, while the frequency-following responses correspond to phase-locked responses in the acoustic nerve.

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Authors and Affiliations

  1. Univ.-Klinik und Poliklinik für HNO-Krankheiten, Sigmund-Freud-Straße, D-5300, Bonn-Venusberg, Federal Republic of Germany

    Norbert Dum & Hasso von Wedel

  2. Zoologisches und Vergleichend-Anatomisches Institut der Universität Bonn, Poppelsdorfer Schloß, D-5300, Bonn, Federal Republic of Germany

    Norbert Dum & Uwe Schmidt

Authors
  1. Norbert Dum
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  2. Uwe Schmidt
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  3. Hasso von Wedel
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Dum, N., Schmidt, U. & von Wedel, H. Frequency-dependence of early auditory evoked responses in the guinea pig. Arch Otorhinolaryngol 236, 59–66 (1982). https://doi.org/10.1007/BF00464058

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  • DOI: https://doi.org/10.1007/BF00464058

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