Summary
Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.
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Meurers, B., Kohlhepp, W., Gold, R. et al. Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. J Neurol 237, 113–116 (1990). https://doi.org/10.1007/BF00314674
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DOI: https://doi.org/10.1007/BF00314674