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Distribution of human adult lactase phenotypes in the population of Austria

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Summary

A total of 528 unrelated, apparently healthy, adult and adolescent Austrians (270 females, 258 males, mean age 22.1 years) were examined for lactose absorption capacity employing a noninvasive field test based on breath hydrogen (H2) determination. Subjects exhibiting a change of breath hydrogen concentration of less than 15 volumes per million (vpm) after a load of 50 g lactose (n=422) were classified as lactorse absorbers, 106 probands (20.1%) showing increases of breath hydrogen concentration between 16 and 111 vpm were diagnosed as lactose malabsorbers. The distribution of the lactase phenotypes was independent of age and sex. Intolerance symptoms after lactose administration were significantly more frequent in lactose malabsorbers. Grouping of probands according to the birth-places of their grandparents revealed significant differences in the distribution of the lactase phenotypes in East and West Austria (East 25%, West 15% lactose malabsorbers). These differences are discussed in the light of the population history of these regions.

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References

  • Buisseret PD, Heinzelmann DI, Youlten LJF, Lessof MH (1978) Prostaglandin-synthesis inhibitors in prophylaxis of food intolerance. Lancet 1:906–907

    Google Scholar 

  • Flatz G, Howell JN, Doench J, Flatz SD (1982) Distribution of physiological adult lactase phenotypes, lactose absorber and malabsorber, in Germany. Hum Genet 62:152–157

    Google Scholar 

  • Howell JN, Schockenhoff T, Flatz G (1981) Population screening for the adult lactase phenotypes with a multiple breaths version of the breath hydrogen test. Hum Genet 57:287–289

    Google Scholar 

  • Johnson RC, Schwitters SY, Cole RE, Ahern FM, Au K (1981) A family study of lactose tolerance. Behav Genet 11:369–372

    Google Scholar 

  • Lisker R, Aguilar L (1978) Double-blind study of milk lactose intolerance. Gastroenterology 74:1283–1285

    Google Scholar 

  • Lisker R, Gonzalez B, Daltabuit M (1975) Recessive inheritance of the adult type of intestinal lactase deficiency. Am J Hum Genet 27: 662–664

    Google Scholar 

  • Sahi T, Isokoski M, Jussila J, Launiala K, Pyöräla K (1973) Recessive inheritance of adult type lactose malabsorption. Lancet 2:823–826

    Google Scholar 

  • Thalhammer O (1975) Frequency of inborn errors of metabolism, especially PKU, in some representative newborn screening centers around the world, a collaborative study. Hum Genet 30:273–286

    Google Scholar 

  • Thalhammer O, Scheiber V (1972) Untersuchung über die Häufigkeit angeborener Stoffwechselanomalien in Ost-und West-Österreich. Hum Genet 15:145–149

    Google Scholar 

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Rosenkranz, W., Hadorn, B., Müller, W. et al. Distribution of human adult lactase phenotypes in the population of Austria. Hum Genet 62, 158–161 (1982). https://doi.org/10.1007/BF00282306

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  • DOI: https://doi.org/10.1007/BF00282306

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