Abstract
Fourteen human thyroid tumors were studied with 18F-fluorodeoxyglucose (FDG) imaging. The proliferative activity and DNA ploidy of the tumors was assessed by DNA flow cytometry. FDG accumulated in a Hürthle cell carcinoma, an anaplastic carcinoma and a thyroid lymphoma, but only slightly or not at all in the three papillary carcinomas studied. Three of the eight benign tumors also accumulated FDG, but two of these were selected for imaging because of a large number of proliferating cells in DNA flow cytometry. Two carcinomas with increased nuclear DNA content retained FDG, but a histologically benign follicular adenoma with DNA aneuploidy did not. We conclude that in addition to malignant thyroid tumors, histologically benign tumors may also accumulate FDG, and therefore the value of FDG scanning in the preoperative diagnosis of thyroid malignancy is limited.
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Ahonen A, Paul R, Aho A, Dean P, Roeda D, Solin O, Virtama P, Ekfors T, Nordman E, Haaparanta M, Wegelius U (1986) Differential diagnosis of bone tumors using fluorodeoxyglucose and three phase 99mTc-DPD scanning. In: Schmidt HAE, Ell PJ, Britton KE (eds) Nuclearmedizin. Proc. ENMC. Schattauer, Stuttgart-New York, pp 441–443
Baisch H, Göhde W, Linden WA (1975) Analysis of PCP-data to determine the fraction of cells in the various phases of cell cycle. Radiat Environm Biophys 12:31–39
Barlogie B, Raber M, Schumann J, Johnson TS, Drewinko B, Swartzendruber DE, Göhde W, Andreeff M, Freireich E (1983) Flow cytometry in clinical cancer research. Cancer Res 43:3982–3997
Bessel EM, Foster AB, Westwood JH (1972) The use of deoxyfluoro-D-glucopyranoses and related compounds in a study of yeast hexokinase specificity. Biochem J 128:199–204
Blair TJ, Evans RG, Bushkirk SJ, Banks PM, Earle JD (1985) Radiotherapeutic management of primary thyroid lymphoma. Int J Radiat Oncol Biol Phys 11:365–370
Di Chiro G, Brooks RA, Bairamian D, Patronas NJ, Kornblith PL, Smith BH, Mansi L (1985) Diagnostic and prognostic value of positron emission tomography using [18F]fluorodeoxyglucose in brain tumors. In: Reivich M, Alavi A (eds) Positron Emission Tomography. Liss New York, pp 291–309
Franssila KO (1975) Prognosis in thyroid carcinoma. Cancer 1975, 36:1138–1146
Friedlander ML, Hedley DW, Taylor IW (1984) Clinical and biological significance of aneuploidy in human tumors. J Clin Pathol 37:961–974
Gallagher BM, Fowler JR, Gutterson NI, MacGregor RR, Wan C-N, Wolf AP (1978) Metabolic trapping as a principle of radiopharmaceutical design: Some factors responsible for the biodistribution of (18F)2-deoxy-glucose. J Nucl Med 19:1154–1161
Greenebaum E, Koss LG, Elequin F, Silver CE (1985) The diagnostic value of flow cytometric DNA measurements in follicular tumors of the thyroid gland. Cancer 56:2011–2018
Haaparanta M, Bergman J, Solin O, Roeda D (1984) A remotely controlled system for the routine synthesis of 18F-2-fluoro-2-deoxy-D-glucose. Nuclearmedizin [Suppl.] 21:823–826
Hammarberg C, Slezak P, Tribukait B (1984) Early detection of malignancy in ulcerative colitis. Cancer 53:291–295
Hedinger C, Sobin LH (1974) Histological typing of thyroid tumours. In: Hedinger C (ed) International Histological Classification of Tumours, No. 11. Geneva, World Health Organization, 17–26
Joensuu H, Klemi P, Eerola E (1986) DNA aneuploidy in follicular adenomas of the thyroid gland. Am J Pathol 124:373–376
Johannessen JV, Sobrinho-Simòes M, Lindmo T, Tangen KO (1982) The diagnostic value of flow cytometric DNA measurements in selected disorders of the human thyroid. Am J Clin Pathol 77:20–25
Kraemer BB, Strigley JR, Batsakis JG, Silva EG, Goepfert H (1985) DNA flow cytometry of thyroid neoplasms. Arch Otolaryngol 111:34–38
Larson SM, Weiden PL, Grunbaum Z, Kaplan HG, Rasey JS, Graham MM, Sale GE, Harp GD, Williams DL (1981) Positron imaging feasibility studies II: Characteristics of 2-deoxy-glucose uptake in rodent and canine neoplasms: Consise communication. J Nucl Med 22:875–879
Löwhagen T, Willems J-S, Lundell G, Sundblad R, Granberg P-O (1981) Aspiration biopsy cytology in diagnosis of thyroid cancer. World J Surg 5:61–73
Paul R, Ahonen A, Roeda D, Nordman E (1985a) Imaging of hepatoma with 18F-fluorodeoxyglucose. Lancet Jan 5, 50–51
Paul R, Johansson R, Kellokumpu-Lehtinen P-L, Söderström K-O, Kangas L (1985b) Tumor localization with 18F-2-fluoro-2-deoxy-D-glucose: comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat. Res Exp Med 185:87–94
Ratib O, Phelps ME, Huang S-C, Henze E, Selin CE, Schelbert HR (1982) Positron tomography with deoxyglucose for estimating local myocardial glucose metabolism. J Nucl Med 23:577–586
Samaan NA, Maheshwari YK, Nader S, Hill CS, Schultz PN, Haynie TP, Hickey RC, Clark RL, Goepfert H, Ibanez ML (1983) Impact of therapy for differentiated carcinoma of the thyroid: an analysis of 706 cases. J Clin Endocrinol Metab 56:1131–1138
Van den Ingh HF, Griffioen G, Cornelisse CJ (1985) Flow cytometric detection of aneuploidy in colorectal adenomas. Cancer Res 45:3392–3397
Vindeløv LL, Christensen IJ, Nissen NI (1983) A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3:323–327
Weber G (1982) Enzymology of cancer cells. N Engl J Med 296:541–551
Yonekura Y, Benua RS, Brill AB, Som P, Yeh SDJ, Kemeny NE, Fowler JS, MacGregor RR, Stamm R, Christman DR, Wolf AP (1982) Increased accumulation of 2-deoxy-2-[18F]fluoro-D-glucose in liver metastases from colon carcinoma. J Nucl Med 23:1133–1137
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Joensuu, H., Ahonen, A. & Klemi, P.J. 18F-fluorodeoxyglucose imaging in preoperative diagnosis of thyroid malignancy. Eur J Nucl Med 13, 502–506 (1988). https://doi.org/10.1007/BF00256624
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DOI: https://doi.org/10.1007/BF00256624