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Metastases to bone affected by Paget's disease

A report of three cases

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Summary

Three cases of metastatic disease in bone affected by Paget's disease are presented. The literature has been reviewed and a total of 26 similar cases found. The occurrence is rare compared to the frequency of sarcomatous transformation in Paget's disease, and low considering the frequency with which metastatic disease and Paget's disease each affect the elderly. This suggests that pagetic bone may resist the implantation of metastatic tumour cells.

Résumé

Présentation de trois cas de lésion métastatique sur os pagétique. La revue de la littérature n'a permis de retrouver que 26 cas semblables. Cette éventualité est donc exceptionnelle, surtout si on la compare à la fréquence de la dégénérescence sarcomateuse dans la maladie de Paget. Ceci est surprenant, étant donné la fréquence chez les sujets âgés tant des lésions osseuses métastatiques que de la maladie de Paget. On peut donc supposer que l'os pagétique résiste à l'implantation des cellules tumorales métastatiques.

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Authors and Affiliations

  1. Department of Radiology, Veterans Administration Medical Center and University of California Medical Center, 92 103, San Diego, CA, USA

    P. Fenton & D. Resnick

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  1. P. Fenton
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  2. D. Resnick
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Fenton, P., Resnick, D. Metastases to bone affected by Paget's disease. International Orthopaedics 15, 397–399 (1991). https://doi.org/10.1007/BF00186887

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