Skip to main content
SpringerLink
Log in

Einsatz von Antidepressiva und MAO-Hemmern in sequentieller Folge oder in Kombination miteinander als effiziente Strategie bei therapieresistenten Depressionen

  • Conference paper
Therapieresistenz unter Antidepressiva-Behandlung

Part of the book series: Tropon-Symposium ((BAYERZNS,volume 5))

Zusammenfassung

Hinsichtlich des Wirkmechanismus der Antidepressiva haben sich in den vergangenen Jahrzehnten zwei alternative Konzepte entwickelt, bei denen sich einerseits das Serotonin, andererseits das Noradrenalin im Mittelpunkt des Interesses befindet. Die häufig verordneten trizyklischen Antidepressiva hemmen in der Regel sowohl die Wiederaufnahme des Serotonins als auch des Noradrenalins, wobei die relative Intensität dieser beiden Wirkkomponenten jeweils unterschiedlich ist. Die Entwicklung neuerer Antidepressiva mit einer selektiven Beeinflussung der nora-drenergen und serotonergen Transmission hat einerseits Möglichkeiten eröffnet, den Einfluß monoaminerger Mechanismen bei der Pathogenese der Depression kritisch zu beleuchten und andererseits die therapeutischen Möglichkeiten in der Depressionsbehandlung erweitert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aberg-Wistedt A (1982) A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. I. Clinical findings. Acta Psychiat Scand 66:50–65

    Article  PubMed  CAS  Google Scholar 

  • Ananth J, Luchins D (1977) A review of combined tricyclic and MAOI therapy. Compr Psychiatr 18:121–134

    Article  Google Scholar 

  • Ayd FJ jr (1975) Psychotropic drug combinations: good and bad. In: Greenblatt LDJ (ed) Drugs in combination with other therapies. Grune & Stratton, New York, pp 165–188

    Google Scholar 

  • Babiak J (1961) A case fatality of overdose of a combination of Parnate Tofranil. Can Med Assoc J 85:377–378

    PubMed  CAS  Google Scholar 

  • Beaumont G (1973) Drug interactions with clomipramine (Anafranil). J Int Med Res 1:480–484

    Google Scholar 

  • Beckmann H (1981) Die medikamentöse Therapie der Depression. Nervenarzt 52:135–146

    PubMed  CAS  Google Scholar 

  • Benkert O, Hippius H (1986) Psychiatrische Pharmakotherapie, 4. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Bowen LW (1964) Fatal hyperpyrexia with antidepressant drugs. Br Med J 2:1465

    Article  PubMed  CAS  Google Scholar 

  • Caglieri-Cingolani R, Bencini A (1982) Due case mortali di reazione tossica per assoziazione di far- mace antidepressivi inhibitori delle mono-amino-ossidase e tricyclici. Riv Pat Nerv Ment 103:21–31

    Google Scholar 

  • Cohen SN, Armstrong MF (1974) Drug interactions: a handbook for clinical use. Williams & Wilkins, Baltimore

    Google Scholar 

  • Davidson J, McLeod M, Law-Yone B, Linnoila M (1978) A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression. Arch Gen Psychiatr 35:639–642

    Article  PubMed  CAS  Google Scholar 

  • Davies G (1960) Side effects of phenelzine. Br Med J 2:1019

    Article  Google Scholar 

  • d’Elia G, Hällström T, Nyström C, Ottosson J-O (1981) Zimelidine vs. maprotiline in depressed outpatients. A preliminary report. Acta Psychiatr Scand 63 [Suppl 290]: 225–235

    Article  Google Scholar 

  • Emrich HM, Berger M, v. Zerssen D (1986) Differential therapy of the depressive syndrome. In: Adv Pharmacother, vol 2. Karger, Basel, pp 57–64

    Google Scholar 

  • Gander DR (1967) The clinical value of monoamine oxidase inhibitors and tricyclic antidepressants in combination. In: Garattini S, Dukes MNG (eds) Antidepressant drugs. Excerpta Medica Foundation, Amsterdam

    Google Scholar 

  • Goldberg RS, Thornton WE (1978) Combined tricyclic-MAOI therapy for refractory depression: a review, with guidelines for appropriate usage. J Clin Pharmacol 18:143–147

    PubMed  CAS  Google Scholar 

  • Graham PM, Potter JM, Patterson JW (1982) Combination monoamine oxidase inhibitor tricyclic antidepressant interaction. Lancet 11:440

    Article  Google Scholar 

  • Guilmot P, Rucquoy G (1967) Dangers in the too rapid substitution of imipramine for a monoamine oxidase inhibitor and in the combination of nialamine-isoniazid-barbiturates at high dosis in psychiatric therapy. Acta Neurol Belg 67:159–171

    CAS  Google Scholar 

  • Kelly D, Cuirgius W, Frommer E, Mitchell-Heggs N, Sargant W (1970) Treatment of phobic states with antidepressants. Br J Psychiatry 116:387–398

    Article  PubMed  CAS  Google Scholar 

  • Kupfer DJ, Detre TP (1978) Tricyclic and monoamine oxidase inhibitor antidepressants - clinical use. In: Iversen L, Iversen S, Snyder S (eds) Handbook of Psychopharmacology 14. Plenum Press, New York London, pp 119–232

    Google Scholar 

  • Lee FI (1961) Imipramine overdosage-report of a fatal case. Br Med J 1:338–339

    Article  PubMed  CAS  Google Scholar 

  • Lingjaerde O, Bratfos O, Bratlid T, Haug JO (1983) A double blind comparison of zimelidine and desipramine in endogenous depression. Acta Psychiatr Scand 68:22–30

    Article  PubMed  CAS  Google Scholar 

  • Loveless AH, Maxwell DR (1965) A comparison of the effects of imipramine, trimipramine, and some other drugs in rabbits treated with a monoamine oxidase inhibitor. Br J Pharmacol 25:158–170

    CAS  Google Scholar 

  • Marks J (1965) Interaction involving drugs used in psychiatry. In: Marks J, Pare CMB (eds) The Scientific Basis of Drug Therapy in Psychiatry. Pergamon Press, Oxford, pp 191–201

    Google Scholar 

  • Marley E, Wozniak KM (1983) Clinical and experimental aspects of interactions between amine oxidase inhibitors and amine reuptake inhibitors. Psychol Med 13:735–749

    Article  PubMed  CAS  Google Scholar 

  • Murphy DL, Sunderland T, Cohen RM (1984) Monoamine oxidase-inhibiting antidepressants - a clinical update. Psychiatr Clin North Am 7:549–562

    PubMed  CAS  Google Scholar 

  • Nolen W (1984) Effects of oxaprotiline, fluvoxamine, sleep deprivation, 5-HTP and tranylcypromine in resistant depression. Abstract, 14th CINP Congress, Florence

    Google Scholar 

  • Nieström C, Hällström T (1987) Comparison between a serotonin and noradrenaline reuptake blocker in the treatment of depressed outpatients. Acta Psychiatr Scand 75:377–382

    Article  Google Scholar 

  • Oefele K v., Grohmann R, Hippius H, Rüther E (1988) Unerwünschte Arzneimittelwirkungen bei der Kombinationsbehandlung mit trizyklischen Antidepressiva und Monoaminoxidase-Hemmern. Nervenarzt 59:118–123

    Google Scholar 

  • Pare CMB (1964) Toxicity of psychotropic drugs: side effects and toxic effects of antidepressants. Proc R Soc Med 57:757–778

    PubMed  CAS  Google Scholar 

  • Pare CMB (1979) Monoamine oxidase inhibitors in resistant depression. Int Pharmacopsychiatr 14:101–109

    CAS  Google Scholar 

  • Pare CMB (1985) The present status of monoamine oxidase inhibitors. Br J Psychiatry 146:576–584

    Article  PubMed  CAS  Google Scholar 

  • Peebles-Brown AE (1985) Hyperpyrexia following psychotropic drug overdose. Anaesthesia 40:1097–1099

    Article  PubMed  CAS  Google Scholar 

  • Ponto LB, Perry PJ, Liskow BI, Scaba HH (1977) Drug therapy reviews: Tricyclic antidepressant and monoamine oxidase inhibitor combination therapy. Am J Hosp Pharm 34:955–961

    Google Scholar 

  • Potter WZ, Calil HM, Extein I, Gold PW, Wehr TA, Goodwin FK (1981) Specific norepinephrine and serotonin uptake inhibitors in man: a crossover study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters. Acta Psychiatr Scand [Suppl 290]: 152–165

    Google Scholar 

  • Quitkin F, Rifkin A, Klein DF (1979) Monoamine oxidase inhibitors: A review of antidepressant effectiveness. Arch Gen Psychiatry 36:749–760

    Article  PubMed  CAS  Google Scholar 

  • Rafaelsen OJ, Gjerris A (1986) MAO-inhibitors revisited II: Clinical implications. In: Pichot P, Berner P, Wolf R, Thau K (eds) Psychiatry - The State of Art, vol II, pp 115–120

    Google Scholar 

  • Ray I (1973) Combinations of antidepressant drugs in the treatment of depressive illness. Can Psychiatr Assoc J 18:399–402

    PubMed  CAS  Google Scholar 

  • Razani J, White K, White J, Simpson G, Sloane RB, Rebal R, Palmer R (1983) The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. Arch Gen Psychiatry 40:657–661

    Article  PubMed  CAS  Google Scholar 

  • Sargant W, Walter CJS, Wright N (1966) New treatment of chronic tension states. Br Med J 1:322–324

    Article  PubMed  CAS  Google Scholar 

  • Schmauß M, Erfurth A (1989) Indikationen für eine Therapie mit MAO-Hemmern. Psychiatr Praxis 16 [Suppl] :2–6

    Google Scholar 

  • Schmauß M, Meller I (1989) Die therapieresistente Depression - Ursachen und Behandlungsmöglichkeiten. Psychiatr Praxis 16:101–108

    Google Scholar 

  • Schmauß M, Kapfhammer HP, Meyr P, Hoff P (1988) Combined MAO-inhibitor and tri(tetra)cyclic antidepressant treatment in therapy resistant depression. Progr Neuro-Psychopharmacol Biol Psychiatr 12:523–532

    Article  Google Scholar 

  • Schuckit M, Robins E, Feighner J (1971) Tricyclic antidepressants and monoamine oxidase inhibitors. Arch Gen Psychiatry 24:509–514

    Article  PubMed  CAS  Google Scholar 

  • Sethna ER (1974) A study of refractory cases of depressive illness and their response to combined antidepressant treatment. Br J Psychiatry 124:265–272 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Sjoqvist F (1965) Psychotropic drugs II: interaction between monoamine oxidase (MAO) inhibitors and other substances. Proc R Soc Med 58:967–978

    PubMed  CAS  Google Scholar 

  • Spiker DG, Pugh DD (1976) Combining tricyclic and monoamine oxidase inhibitor antidepressants. Arch Gen Psychiatry 33:828–830

    Article  PubMed  CAS  Google Scholar 

  • Stanley B, Pal WR (1964) Fatal hyperpyrecia with phenelzine and imipramine. Br Med J 2:1011

    Article  PubMed  CAS  Google Scholar 

  • Teas GA (1981) Toxic delirium resulting from combination antidepressant therapy. Am J Psychiatry 138:1127

    PubMed  CAS  Google Scholar 

  • Tollefson GD (1983) Monoamine oxidase inhibitors: a review. J Clin Psychiatry 44:280–288

    PubMed  CAS  Google Scholar 

  • White K, Simpson G (1981) Combined MAOI-tricyclic antidepressant treatment. A reevaluation. J Clin Psychopharmacol 1:264–282

    Article  PubMed  CAS  Google Scholar 

  • White K, Simpson G (1984) The combined use of MAOIs and Tricyclics. J Clin Psychiatry 45(2):67–69

    PubMed  CAS  Google Scholar 

  • White K, Simpson G (1985) Should the use of MAO inhibitors be abandoned. Integr Psychiatry 3:34–45

    Google Scholar 

  • White K, Pistole TA, Boyd J (1980) Combined monoamine oxidase inhibitor tricyclic antidepressant treatment. A pilot study. Am J Psychiatry 137:1422–1425

    PubMed  CAS  Google Scholar 

  • Winston F (1971) Combined antidepressant therapy. Br J Psychiatry 118:301–304

    Article  PubMed  CAS  Google Scholar 

  • Young JPR, Lader MH, Hughes WC (1979) Controlled trial of trimipramine, monoamine oxidase inhibitors, and combined treatment in depressed outpatients. Br Med J 2:1315–1317

    Article  PubMed  CAS  Google Scholar 

  • Zisook S (1985) A clinical overview of monoamine oxidase inhibitors. Psychosomatics 26:240–251

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. Schmauss
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Erfurth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Scholderle
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrie, Universitäts-Nervenklinik, Sigmund-Freud-Straße 25, D-5300, Bonn 1, Deutschland

    Hans-Jürgen Möller

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schmauss, M., Erfurth, A., Scholderle, M. (1990). Einsatz von Antidepressiva und MAO-Hemmern in sequentieller Folge oder in Kombination miteinander als effiziente Strategie bei therapieresistenten Depressionen. In: Möller, HJ. (eds) Therapieresistenz unter Antidepressiva-Behandlung. Tropon-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84236-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84236-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52765-7

  • Online ISBN: 978-3-642-84236-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation