Skip to main content
SpringerLink
Log in

Andrologie in der interdisziplinären Reproduktionsmedizin

  • Chapter
Book cover Reproduktionsmedizin

Zusammenfassung

Eine Infertilität liegt definitionsgemäß vor, wenn bei einem Paar trotz regelmäßigem, ungeschütztem Geschlechtsverkehr innerhalb eines Jahres keine Schwangerschaft eingetreten ist (Rowe et al. 2000). Hierbei wird zwischen primärer und sekundärer Infertilität unterschieden, je nachdem, ob früher bereits einmal eine Schwangerschaft induziert wurde (bezogen auf das Paar oder den einzelnen Partner).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abdel-Hafez F, Bedaiwy M, El-Nashar SA, Sabanegh E, Desai N (2009) Techniques for cryopreservation of individual or small numbers of human spermatozoa: a systematic review. Hum Reprod Update 15: 153–164

    Article  Google Scholar 

  • Ainsworth C, Nixon B, Aitken RJ (2005) Development of a novel electrophoretic system for the isolation of human spermatozoa. Hum Reprod 20: 2261–2270

    Article  PubMed  CAS  Google Scholar 

  • Aitken RJ, De Iuliis GN (2010) On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod 16: 3–13

    Article  PubMed  CAS  Google Scholar 

  • Aitken RJ, Buckingham D, West K et al. (1992) Differential contribution of leukocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. J Reprod Fertil 94: 451–462

    Article  PubMed  CAS  Google Scholar 

  • Allam J-P, Fathy A, Haidl F, Schuppe H-C, Haidl G (2010) Ein neuer Ansatz zur Diagnostik chronischer Genitaltraktentzündungen (Abstract). Urologe 49 (Suppl 1): 67

    Google Scholar 

  • Balaban B, Yakin K, Alatas C, Oktem O, Isiklar A, Urman B (2011) Clinical outcome of intracytoplasmic injection of spermatozoa morphologically selected under high magnification: a prospective randomized study. Reprod Biomed Online [Epub ahead of print]

    Google Scholar 

  • Barratt CL, Aitken RJ, Björndahl L, Carrell DT, de Boer P, Kvist U, Lewis SE, Perreault SD, Perry MJ, Ramos L, Robaire B, Ward S, Zini A (2010) Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications – a position report. Hum Reprod 25: 824–838

    Article  PubMed  Google Scholar 

  • Barratt CL, Björndahl L, Menkveld R, Mortimer D (2011) ESHRE special interest group for andrology basic semen analysis course: a continued focus on accuracy, quality, efficiency and clinical relevance. Hum Reprod 26: 3207–3212

    Article  PubMed  CAS  Google Scholar 

  • Barroso G, Valdespin C, Vega E, Kershenovich R, Avila R, Avendano C, Oehninger S (2009) Developmental sperm contributions: fertilization and beyond. Fertil Steril 92: 835–848

    Article  PubMed  CAS  Google Scholar 

  • Bartoov B, Berkovitz A, Eltes F, Kogosowski A, Menezo Y, Barak Y (2002) Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome. J Androl 23: 1–8

    PubMed  Google Scholar 

  • Baukloh V; German Society for Human Reproductive Biology (2002) Retrospective multicentre study on mechanical and enzymatic preparation of fresh and cryopreserved testicular biopsies. Hum Reprod 17: 1788–1794

    Article  PubMed  Google Scholar 

  • Bellver J, Meseguer M, Muriel L, García-Herrero S, Barreto MA, Garda AL, Remohí J, Pellicer A, Garrido N (2010) Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology. Hum Reprod 25: 1713–1721

    Article  PubMed  CAS  Google Scholar 

  • Bergmann M (2006) Evaluation of testicular biopsy samples from the clinical perspective. In: Schill WB, Comhaire F, Hargreave TB (eds) Andrology for the clinician. Springer, Berlin Heidelberg New York, pp 454–461

    Chapter  Google Scholar 

  • Bergmann M, Kliesch S (1998) Hodenbiopsie. In: Krause W, Weidner W (Hrsg) Andrologie – Krankheiten der männlichen Geschlechtsorgane. 3. Auflage. Enke, Stuttgart, pp 66–71

    Google Scholar 

  • Berkovitz A, Eltes F, Yaari S, Katz N, Barr I, Fishman A, Bartoov B (2005) The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm. Hum Reprod 20: 185–190

    Article  PubMed  Google Scholar 

  • Bezold G, Politch JA, Kiviat NB et al. (2007) Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 87: 1087–1097

    Article  PubMed  Google Scholar 

  • Björndahl L (2010) The usefulness and significance of assessing rapidly progressive spermatozoa. Asian J Androl 12: 33–35

    Article  PubMed  Google Scholar 

  • Björndahl L, Mortimer D, Barratt CLR, Castilla JA, Menkveld R, Kvist U, Alvarez JG, Haugen TB (2010) A Practical Guide to Basic Laboratory Andrology. Univ Press, Cambridge

    Google Scholar 

  • Boitrelle F, Ferfouri F, Petit JM, Segretain D, Tourain C, Bergere M, Bailly M, Vialard F, Albert M, Selva J (2011) Large human sperm vacuoles observed in motile spermatozoa under high magnification: nuclear thumbprints linked to failure of chromatin condensation. Hum Reprod 26: 1641–1649

    Article  CAS  Google Scholar 

  • Boivin J, Bunting L, Collins JA, Nygren KG (2007) International estimates of infertility prevalence and treatment seeking: potential need and demand for infertility medical care. Hum Reprod 22: 1506–12

    Article  PubMed  Google Scholar 

  • Bohring C, Krause W (2003) Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis. Hum Reprod 18: 915–924

    Article  PubMed  CAS  Google Scholar 

  • Borges E Jr, Rossi LM, Locambo de Freitas CV, Guilherme P, Bonetti TC, Iaconelli A, Pasqualotto FF (2007) Fertilization and pregnancy outcome after intracytoplasmic injection with fresh or cryopreserved ejaculated spermatozoa. Fertil Steril 87 (2): 316–320

    Article  PubMed  Google Scholar 

  • Brandes M, Hamilton CJ, Van Der Steen JO, de Bruin JP, Bots RS, Nelen WL, Kremer JA (2011) Severity of oligo-asteno-teratozoospermia no longer determines overall success rate in male subfertility. Int J Androl 34: 614–623

    Article  PubMed  CAS  Google Scholar 

  • Bundesärztekammer (2011) Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen. B 4, Ejakulatuntersuchungen. Dtsch Ärztebl 108: A55–A58

    Google Scholar 

  • Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, Erenpreiss J, Giwercman A (2007) Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 22: 174–179

    Article  PubMed  CAS  Google Scholar 

  • Bungum M, Bungum L, Giwercman A (2011) Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility. Asian J Androl 13: 69–75

    Article  PubMed  CAS  Google Scholar 

  • Centers for Disease Control and Prevention (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Vol 59, No RR-12

    Google Scholar 

  • Chan PJ, Jacobson JD, Corselli JU, Patton WC (2006) A simple zeta method for sperm selection based on membrane charge. Fertil Steril 85: 481–486

    Article  PubMed  CAS  Google Scholar 

  • Chemes HE, Rawe VY (2003) Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile emn. Hum Reprod Update 9: 405–428

    Article  PubMed  Google Scholar 

  • Comhaire FH, Dhooge W, Zalata A, Depuydt C, Mahmoud A, Schoonjans F (1998) Östrogenartig wirkende Umweltnoxen. Fertilität 13: S6–S8

    Google Scholar 

  • Cooper TG, Hellenkemper B, Jonckheere J, Callewaert N, Grootenhuis AJ, Kersemaekers WM, Leung A, Wang C (2006) Azoospermia: virtual reality or possible to quantify? J Androl 27: 483–490

    Article  PubMed  CAS  Google Scholar 

  • Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, Vogelsong KM (2010) World Health Organization reference values for human semen characteristics. Hum Reprod Update 16: 231–245

    Article  PubMed  Google Scholar 

  • Cottell E, Harrison RF, McCaffrey M et al. (2000) Are seminal fluid microorganisms of significance or merely contaminants? Fertil Steril 74: 465–470

    Article  PubMed  CAS  Google Scholar 

  • Cunningham KA, Beagley KW (2008) Male genital tract chlamydial infection: implications for pathology and infertility. Biol Reprod 2008; 79: 180–189

    Article  PubMed  CAS  Google Scholar 

  • Dam AH, Feenstra I, Westphal JR, Ramos L, van Golde RJ, Kremer JA (2007) Globozoospermia revisited. Hum Reprod Update 13: 63–75

    Article  PubMed  CAS  Google Scholar 

  • Delbes G, Hales BF, Robaire B (2007) Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity. J Androl 28: 241–249

    Article  PubMed  CAS  Google Scholar 

  • De Kretser DM (1997) Male infertility. Lancet 349: 787–790

    Article  PubMed  CAS  Google Scholar 

  • De Kretser DM, Holstein AF (1976) Testicular biopsy and abnormal germ cells. In: Hafez ES (ed) Human semen and fertility regulation in men. Mosby, St. Louis, pp 332–343

    Google Scholar 

  • De Mateo S, Ramos L, Van Der Vlag J, de Boer P, Oliva R (2011) Improvement in chromatin maturity of human spermatozoa selected through density gradient centrifugation. Int J Androl 34: 256–267

    Article  PubMed  Google Scholar 

  • De Vos A, van de Velde H, Joris H, Verheyen G, Devroey P, van Steirteghem A (2003) Influence of individual sperm morphology on fertilization, embryo morphology, and pregnancy outcome of intracytoplasmic sperm injection. Fertil Steril 79: 42–48

    Article  PubMed  Google Scholar 

  • Deutsche Gesellschaft für Andrologie et al. (2011) Stellungnahme der Deutschen Gesellschaft für Andrologie (DGA) [federführend], des Arbeitskreises Andrologie der Dermatologen (AAD) der Deutschen Dermatologischen Gesellschaft (DDG), der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF), der Deutschen Gesellschaft für Reproduktionsmedizin (DGRM), der Deutschen Gesellschaft für Urologie (DGU) und der Sektion Reproduktionsbiologie und –medizin (SRBM) der Deutschen Gesellschaft für Endokrinologie (DGE) zu den Richtlinien des Bundesausschusses der Ärzte und Krankenkassen über ärztliche Maßnahmen zur künstlichen Befruchtung unter Berücksichtigung der aktuellen Empfehlungen der Weltgesundheitsorganisation (WHO) zur Untersuchung und Aufarbeitung des menschlichen Ejakulates. J Reproduktionsmed Endokrinol 8 (6): 426–427

    Google Scholar 

  • Deutsches IVF-Register – DIR (2004) [http://www.deutsches-ivf-register.de]

  • Deutsches IVF-Register –DIR (2010) DIR-Jahrbuch 2009. J Reproduktionsmed Endokrinol 7: 470–497

    Google Scholar 

  • Diemer T, Hauptmann A, Weidner W (2011) Therapie der Azoospermie: Operative Spermiengewinnung (MESA, TESE, Mikro-TESE). Urologe A 50: 38–46

    Article  PubMed  CAS  Google Scholar 

  • Dirican EK, Ozgun OD, Akarsu S, Akin KO, Ercan O, Ugurlu M, Camsari C, Kanyilmaz O, Kaya A, Unsal A (2008) Clinical outcome of magnetic activated cell sorting of non-apoptotic spermatozoa before density gradient centrifugation for assisted reproduction. J Assist Reprod Genet 25: 375–381

    Article  PubMed  Google Scholar 

  • Dohle GR, Colpi GM, Hargreave TB, Papp GK, Jungwirth A, Weidner W, The EAU Working Group on Male Infertility (2005) EAU guidelines on male infertility. Eur Urol 48: 703–711

    Article  PubMed  CAS  Google Scholar 

  • Donnelly ET, O‘Connell M, McClure N, Lewis SE (2000) Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa. Hum Reprod 15: 1552–1561

    Article  PubMed  CAS  Google Scholar 

  • Dunson DB, Baird DD, Colombo B (2004) Increased infertility with age in men and women. Obstet Gynecol 103: 51–56

    Article  PubMed  Google Scholar 

  • Du Plessis SS, Kashou AH, Benjamin DJ, Yadav SP, Agarwal A (2011) Proteomics: a subcellular look at spermatozoa. Reprod Biol Endocrinol 9: 36

    Article  PubMed  CAS  Google Scholar 

  • Eimers JM, te Velde ER, Gerritse R, Vogelzang ET, Looman CW, Habbema JD (1994) The prediction of the chance to conceive in subfertile couples. Fertil Steril 61: 44–52

    PubMed  CAS  Google Scholar 

  • Evenson DP, Jost LK, Marshall D, Zinaman MJ, Clegg E, Purvis K, de Angelis P, Claussen OP (1999) Utility of the sperm chromatin assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 14: 1039–1049

    Article  PubMed  CAS  Google Scholar 

  • French DB, Sabanegh ES Jr, Goldfarb J, Desai N (2010) Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? Fertil Steril 93: 1097–103

    Article  PubMed  Google Scholar 

  • Garolla A, Pizzol D, Foresta C (2011) The role of human papillomavirus on sperm function. Curr Opin Obstet Gynecol 23: 232–237

    Article  PubMed  Google Scholar 

  • Gerber PA, Kruse R, Hirchenhain J, Krüssel JS, Neumann NJ (2008) Pregnancy after laser-assisted selection of viable spermatozoa before intracytoplasmatic sperm injection in a couple with male primary cilia dyskinesia. Fertil Steril 89: 1826.e9–12

    Article  PubMed  Google Scholar 

  • Gianaroli L, Magli MC, Ferraretti AP, Crippa A, Lappi M, Capitani S, Baccetti B (2010) Birefringence characteristics in sperm heads allow for the selection of reacted spermatozoa for intracytoplasmic sperm injection. Fertil Steril 93: 807–813

    Article  PubMed  Google Scholar 

  • Gillam MP, Molitch ME, Lombardi G, Colao A (2006) Advances in the treatment of prolactinomas. Endocr Rev 27: 485–534

    Article  PubMed  CAS  Google Scholar 

  • Giwercman A, von der Maase H, Skakkebaek NE (1993) Epidemiological and clinical aspects of carcinoma in situ of the testis. Eur Urol 23: 104–10

    PubMed  CAS  Google Scholar 

  • Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G (2005) Definition and prevalence of subfertility and infertility. Hum Reprod 20: 1144–1147

    Article  PubMed  CAS  Google Scholar 

  • Grimes DA, Lopez LM (2007) »Oligozoospermia«, »azoospermia«, and other semen-analysis terminology: the need for better science. Fertil Steril 88: 1491–1494

    Article  PubMed  Google Scholar 

  • Grunewald S, Miska W, Miska G, Rasch M, Reinhardt M, Glander HJ, Paasch U (2007) Molecular glass wool filtration as a new tool for sperm preparation. Hum Reprod 22: 1405–1412

    Article  PubMed  CAS  Google Scholar 

  • Grunewald S, Reinhardt M, Blumenauer V, Said TM, Agarwal A, Abu Hmeidan F, Glander HJ, Paasch U (2009) Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. Fertil Steril 92: 572–577

    Article  PubMed  Google Scholar 

  • Guzick DS, Overstreet JW, Factor-Litwack P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, Xu D, Vogel DL (2001) Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 345: 1388–1393

    Article  PubMed  CAS  Google Scholar 

  • Haidl G (2002) Management strategies for male factor infertility. Drugs 62: 1741–1753

    Article  PubMed  CAS  Google Scholar 

  • Haidl G, Schuppe H-C (2006) Cytomorphological semen analysis. In: Schill W-B, Comhaire F, Hargreave TB (eds) Andrology for the clinician. Springer, Berlin Heidelberg New York, pp 395–400

    Chapter  Google Scholar 

  • Haidl G, Schuppe HC (2011) Infektionen und Entzündungen des männlichen Genitaltrakts. In: Krause W, Weidner W, Diemer T, Sperling H (Hrsg) Andrologie – Krankheiten der männlichen Geschlechtsorgane, 4. Aufl. Georg Thieme Verlag, Stuttgart, S 347–353

    Google Scholar 

  • Hammadeh ME, Stieber M, Haidl G, Schmidt W (1998) Association between sperm cell chromatin condensation, morphology based on strict criteria, and fertilization, cleavage and pregnancy rates in an IVF program. Andrologia 30: 29–35

    Article  PubMed  CAS  Google Scholar 

  • Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81: 384–392

    Article  PubMed  Google Scholar 

  • Henkel RR, Schill WB (2003) Sperm preparation for ART. Reprod Biol Endocrinol 1: 108

    Article  PubMed  Google Scholar 

  • Henkel R, Hajimohammad M, Stalf T, Hoogendijk C, Mehnert C, Menkveld R, Gips H, Schill W-B, Kruger TF (2004) Influence of deoxyribonucleic acid damage on fertilization and pregnancy. Fertil Steril 81: 965–972

    Article  PubMed  CAS  Google Scholar 

  • Henkel R, Kierspel E, Stalf T, Mehnert C, Menkveld R, Tinneberg HR, Schill WB, Kruger TF (2005a) Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients. Fertil Steril 83: 635–642

    Article  CAS  Google Scholar 

  • Henkel R, Maaß G, Bödeker R-H, Scheibelhut C, Stalf T, Mehnert C, Schuppe H-C, Jung A, Schill W-B (2005b) Sperm function and assisted reproduction technology. Reprod Med Biol 4: 7–30

    Google Scholar 

  • Huszar G, Ozenci CC, Cayli S, Zavaczki Z, Hansch E, Vigue L (2003) Hyaluronic acid binding by human sperm indicates cellular maturity, viability, and unreacted acrosomal status. Fertil Steril 79 (Suppl 3): 1616–1624

    Article  PubMed  Google Scholar 

  • Jakab A, Sakkas D, Delpiano E, Cayli S, Kovanci E, Ward D, Revelli A, Huszar G (2005) Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. Fertil Steril 84: 1665–1673

    Article  PubMed  Google Scholar 

  • Kamischke A, Nieschlag E (2002) Update on medical treatment of ejaculatory disorders. Int J Androl 25: 333–344

    Article  PubMed  CAS  Google Scholar 

  • Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K (2010) Oocyte activation, phospholipase C zeta and human infertility. Hum Reprod Update 16: 690–703

    Article  PubMed  CAS  Google Scholar 

  • Kelleher S, Wishart SM, Liu PY et al. (2001) Long-term outcomes of elective human sperm cryostorage. Hum Reprod 16: 2632–2639

    Article  PubMed  CAS  Google Scholar 

  • Kheirollahi-Kouhestani M, Razavi S, Tavalaee M, Deemeh MR, Mardani M, Moshtaghian J, Nasr-Esfahani MH (2009) Selection of sperm based on combined density gradient and Zeta method may improve ICSI outcome. Hum Reprod 24: 2409–2416

    Article  PubMed  CAS  Google Scholar 

  • Kliesch S, Zitzmann M, Behre HM (2011) Fertilität bei Patienten mit einem Klinefelter-Syndrom (47,XXY). Urologe 50: 26–32

    Article  PubMed  CAS  Google Scholar 

  • Köhn FM, Schuppe HC, Haidl G (2010) Andrologie. Hautarzt 61: 787–785

    Article  PubMed  Google Scholar 

  • Köhn F-M, Schuppe H-C (2011) Spermiogramme korrekt erstellen – Aktuelle WHO-Vorgaben und BÄK-Richtlinien. Uro News 15 (4): 46–51

    Google Scholar 

  • Köhn FM, Schuppe HC, Jung A, Schulze W (2005) Bedeutung der Hodenbiopsie in der Andrologie. J Dtsch Dermatol Ges 3: 532–557

    Article  PubMed  Google Scholar 

  • Kopa Z, Wenzel J, Papp GK et al. (2005) Role of granulocyte elastase and interleukin-6 in the diagnosis of male genital tract inflammation. Andrologia 37: 188–194

    Article  PubMed  CAS  Google Scholar 

  • Krause WKH (2008) Drugs compromising male sexual health. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Krause W, Herbstreit F, Slenzka W (2002) Are viral infections the cause of leukocytospermia? Andrologia 34: 87–90

    Article  PubMed  CAS  Google Scholar 

  • Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E (2004) Klinefelter’s syndrome. Lancet 364: 273–283

    Article  PubMed  CAS  Google Scholar 

  • Lishko PV, Botchkina IL, Kirichok Y (2011) Progesterone activates the principal Ca2+ channel of human sperm. Nature (London) 471: 387–391

    Article  CAS  Google Scholar 

  • Liu DY, Baker HW (2003) Frequency of defective sperm-zona pellucida interaction in severely teratozoospermic infertile men. Hum Reprod 18: 802–807

    Article  PubMed  Google Scholar 

  • Liu de Y, Liu ML, Garrett C, Baker HW (2007) Comparison of the frequency of defective sperm-zona pellucida (ZP) binding and the ZP-induced acrosome reaction between subfertile men with normal and abnormal semen. Hum Reprod 22: 1878–84

    Article  PubMed  Google Scholar 

  • Magelssen H, Haugen TB, von Düring V et al. (2005) Twenty years experience with semen cryopreservation in testicular cancer patients: who needs it? Eur Urol 48: 779–85

    Article  PubMed  CAS  Google Scholar 

  • Mallidis C, Wistuba J, Bleisteiner B, Damm OS, Gross P, Wübbeling F, Fallnich C, Burger M, Schlatt S (2011) In situ visualization of damaged DNA in human sperm by Raman microspectroscopy. Hum Reprod 26: 1641–1649

    Article  PubMed  CAS  Google Scholar 

  • Marconi M, Pilatz A, Wagenlehner FM et al. (2009a) Are antisperm antibodies really associated with proven chronic inflammatory and infectious diseases of the male reproductive tract? Eur Urol 56: 708–715

    Article  Google Scholar 

  • Marconi M, Pilatz A, Wagenlehner F et al. (2009b) Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 35: 299–309

    Article  CAS  Google Scholar 

  • Marconi M, Keudel A, Diemer T, Bergmann M, Steger K, Schuppe H-C, Weidner W (2012) Combined trifocal- and micro-TESE is the best technique for testicular sperm retrieval in »low chance« non-obstructive azoospermia. Eur Urol Mar 14 [Epub ahead of print]

    Google Scholar 

  • Martınez-Prado E, Bermudez MIC (2010) Expression of IL-6, IL-8, TNF-a, IL-10, HSP-60, anti-HSP-60 antibodies, and anti-sperm antibodies, in semen of men with leukocytes and/or bacteria. Am J Reprod Immunol 63: 233–243

    Article  PubMed  CAS  Google Scholar 

  • McLachlan RI, O’Bryan MK (2010) Clinical review: state of the art for genetic testing of infertile men. J Clin Endocrinol Metab 95: 1013–1024

    Article  PubMed  CAS  Google Scholar 

  • McLachlan RI, Rajpert-De Meyts EK, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE (2007) Histological evaluation of the human testis – approaches to optimizing the clinical value of the assessment: Mini Review. Hum Reprod 22: 2–16

    Article  PubMed  CAS  Google Scholar 

  • Menkveld R (2010) Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl 12: 47–58

    Article  PubMed  Google Scholar 

  • Menkveld R, Franken DR, Kruger TF, Oehninger S, Hodgen GD (1991) Sperm selection capacity of the human zona pellucida. Molec Reprod Develop 30: 346–352

    Article  CAS  Google Scholar 

  • Menkveld R, Rhemrev JP, Franken DR, Vermeiden JP, Kruger TF (1996) Acrosomal morphology as a novel criterion for male fertility diagnosis: relation with acrosin activity, morphology (strict criteria), and fertilization in vitro. Fertil Steril 65: 637–644

    PubMed  CAS  Google Scholar 

  • Menkveld R, Wong WY, Lombard CJ, Wetzels AM, Thomas CM, Merkus HM, Steegers-Theunissen RP (2001) Semen parameters including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds. Hum Reprod 16: 1165–1171

    Article  PubMed  CAS  Google Scholar 

  • Meseguer M, Molina N, García-Velasco JA et al. (2006) Sperm cryopreservation in oncological patients: a 14-year follow-up study. Fertil Steril 85: 640–5

    Article  PubMed  Google Scholar 

  • Montag M, Schwarz C, Köster M, Van Der Ven K, Van Der Ven H (2009) IMSI (intracytoplasmic morphologically selected sperm injection): Therapieoptimierung bei ausgeprägter Störung der Spermatogene? J Reproduktionsmed Endokrinol 6: 153–155

    Google Scholar 

  • Muratori M, Luconi M, Marchiani S, Forti G, Baldi E (2009) Molecular markers of human sperm functions. Int J Androl 32: 25–45

    Article  PubMed  CAS  Google Scholar 

  • Nachtigall RD (2006) International disparities in access to infertility services Fertil Steril 85: 871–875

    Article  PubMed  Google Scholar 

  • Nasr-Esfahani MH, Razavi S, Vahdati AA, Fathi F, Tavalaee M (2008) Evaluation of sperm selection procedure based on hyaluronic acid binding ability on ICSI outcome. J Assist Reprod Genet 25: 197–203

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag E (2009) Aufgaben und Ziele der Andrologie. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes, 3. Aufl. Springer, Berlin Heidelberg New York, S 4–12

    Google Scholar 

  • Noordam MJ, Repping S (2006) The human Y chromosome: A masculine chromosome. Curr Opin Genet Dev 16: 225–232

    Article  PubMed  CAS  Google Scholar 

  • Ochsendorf FR (1999) Infections of the male genital tract and reactive oxygen species. Hum Reprod Update 5: 399–420

    Article  CAS  Google Scholar 

  • Oleszczuk K, Giwercman A, Bungum M (2011) Intra-individual variation of the sperm chromatin structure assay DNA fragmentation index in men from infertile couples. Hum Reprod 26: 3244–3248

    Article  PubMed  CAS  Google Scholar 

  • Ombelet W, Bosmans E, Janssen M et al. (1997) Semen parameters in a fertile versus subfertile population: a need for change in the interpretation of semen testing. Hum Reprod 12: 987–993

    Article  PubMed  CAS  Google Scholar 

  • Paasch U, Grunewald S, Glander HJ (2007) DNA-Schäden ejakulierter Spermatozoen: ein prädiktiver Faktor der männlichen Infertilität. Journal für Reproduktionsmedizin und Endokrinologie 4 (3): 124–139

    CAS  Google Scholar 

  • Pantke P, Diemer T, Marconi M, Bergmann M, Steger K, Schuppe H-C, Weidner W (2008) Testicular sperm retrieval in azoospermic men. Eur Urol Suppl 7: 703–714

    Article  Google Scholar 

  • Parmegiani L, Cognigni GE, Bernardi S, Troilo E, Ciampaglia W, Filicori M (2010) »Physiologic ICSI«: Hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality. Fertil Steril 93: 598–604

    Article  PubMed  Google Scholar 

  • Penna G, Mondaini N, Amuchastegui S et al. (2007) Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Eur Urol 51: 524–533

    Article  PubMed  CAS  Google Scholar 

  • Pierik FH, Dohle GR, van Muiswinkel JM, Vreeburg JT, Weber RF (1999) Is routine scrotal ultrasound advantageous in infertile men? J Urol 162: 1618–1620

    Article  PubMed  CAS  Google Scholar 

  • Ramasamy R, Ricci JA, Palermo GD, Gosden LV, Rosenwaks Z, Schlegel PN (2009) Successful fertility treatment for Klinefelter’s syndrome. J Urol 182, 1108–1113

    Article  PubMed  CAS  Google Scholar 

  • Revel A, Haimov-Kochman R, Porat A (2005) In vitro fertilization-intracytoplasmic sperm injection success rates with cryopreserved sperm from patients with malignant disease. Fertil Steril 84: 118–122

    Article  PubMed  Google Scholar 

  • Ricci G, Presani G, Guaschino S et al. Leukocyte detection in human semen using flow cytometry. Hum Reprod 2000; 15: 1329–1337

    Article  PubMed  CAS  Google Scholar 

  • Rørth M, Rajpert-De Meyts E, Andersson L, Dieckmann K-P, Fossa SD, Grigor KM, Hendry WF, Herr HW, Looijenga LHJ, Oosterhuis JW, Skakkebaek NE (2000) Carcinoma in situ in the testis. Scand J Urol Nephrol 205 (Suppl): 166–186

    Article  Google Scholar 

  • Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AMA (2000) WHO manual for the standardized investigation, diagnosis and management of the infertile male. Univ Press, Cambridge

    Google Scholar 

  • Rusz A, Pilatz A, Wagenlehner F, Linn T, Diemer T, Schuppe HC, Lohmeyer J, Hossain H, Weidner W (2012) Influence of urogenital infections and inflammation on semen quality and male fertility. World J Urol 30: 23–30

    Article  PubMed  CAS  Google Scholar 

  • Said TM, Land JA (2011) Effects of advanced selection methods on sperm quality and ART outcome: a systematic review. Hum Reprod Update 17: 719–733

    Article  PubMed  Google Scholar 

  • Said TM, Grunewald S, Paasch U, Glander H-J, Baumann T, Kriegel C, Li L, Agarwal A (2005) Advantage of combining magnetic cell separation with sperm preparation techniques. Reprod BioMed Online 10: 740–746

    Article  PubMed  Google Scholar 

  • Salzbrunn A, Benson DM, Holstein AF et al. A new concept for the extraction of testicular spermatozoa as a tool for assisted fertilization (ICSI). Hum Reprod 1996; 11: 752–755

    Article  PubMed  CAS  Google Scholar 

  • Schiefer HG (1998) Microbiology of male urethroadnexitis: diagnostic procedures and criteria for aetiologic classification. Andrologia 30 (Suppl 1): 7–13

    Article  PubMed  Google Scholar 

  • Schiff JD, Palermo GD, Veeck LL, Goldstein M, Rosenwaks Z, Schlegel PN (2005) Success of testicular sperm injection and intracytoplasmic sperm injection in men with Klinefelter syndrome. J Clin Endocrinol Metab 90: 6263–6267

    Article  PubMed  CAS  Google Scholar 

  • Schover LR, Brey K, Lichtin A et al. (2002a) Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol 20: 1890–1897

    Article  Google Scholar 

  • Schover LR, Brey K, Lichtin A et al. (2002b) Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol 20: 1880–1889

    Article  Google Scholar 

  • Schrader M, Mueller M, Sofikitis N et al. (2003) »ONCO-TESE«: Testicular sperm extraction in azoospermic cancer patients before chemotherapy – new guidelines? Urology 61: 421–425

    Article  PubMed  CAS  Google Scholar 

  • Schuppe HC, Köhn F-M (2011) Kryospermakonservierung. In: Krause W, Weidner W, Diemer T, Sperling H (Hrsg) Andrologie – Krankheiten der männlichen Geschlechtsorgane, 4. Aufl. Georg Thieme Verlag, Stuttgart, S 182–188

    Google Scholar 

  • Schuppe H-C, Köhn F-M (2012) Andrologie. In: Plewig, G, Landthaler M, Burgdorf WHC, Hertl M, Ruzicka T (Hrsg) Braun-Falco‘s Dermatologie, Venerologie und Allergologie, Kap. 84. 6. Aufl. Springer, Berlin Heidelberg New York, Abb. 84.1

    Google Scholar 

  • Schuppe H-C, Meinhardt A, Allam JP, Bergmann M, Weidner W, Haidl G (2008) Chronic orchitis – a neglected cause of male infertility? Andrologia 40: 84–91

    Article  PubMed  Google Scholar 

  • Schuppe H-C, Hellenkemper B, Cooper TG, Haidl G, Ochsendorf FR, Köhn F-M (2010a) Ejakulatanalyse nach WHO-Empfehlungen. Ärztliche Praxis Dermatologie/Allergologie 1: 32–36

    Google Scholar 

  • Schuppe H-C, Haidl G, Köhn F-M (2010b) Fertilitätsstörungen des Mannes: Welche medikamentösen Therapieoptionen gibt es? Uro News 14 (4): 32–40

    Google Scholar 

  • Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ (2011) Antioxidants for male subfertility. Cochrane Database Syst Rev 19: CD007411

    Google Scholar 

  • Simoni M, Tüttelmann F, Gromoll J, Nieschlag E (2008) Clinical consequences of microdeletions of the Y chromosome: The extended Münster experience. Reprod Biomed Online 16: 289–303

    Article  PubMed  CAS  Google Scholar 

  • Sijstermans K, Hack WW, Meijer RW, Van Der Voort-Doedens LM (2008) The frequency of undescended testis from birth to adulthood: a review. Int J Androl 31: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Snick HK, Snick TS, Evers JL, Collins JA (1997) The spontaneous pregnancy prognosis in untreated subfertile couples: the Walcheren primary care study. Hum Reprod 12: 1582–8

    Article  PubMed  CAS  Google Scholar 

  • Stalf T, Mehnert C, Hajimohammad A, Manolopoulos, Shen Y, Schuppe H-C, Diemer T, Schill W-B, Weidner W, Tinneberg H-R (2005) Influence of motility and vitality on intracytoplasmic sperm injection with ejaculated and testicular spermatozoa. Andrologia 37: 125–130

    Article  PubMed  CAS  Google Scholar 

  • Steger K, Wilhelm J, Konrad L, Stalf T, Greb R, Diemer T, Kliesch S, Bergmann M, Weidner W (2008) Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men. Hum Reprod 23: 11–16

    Article  PubMed  CAS  Google Scholar 

  • Steger K, Cavalcanti MC, Schuppe HC (2011) Prognostic markers for competent human spermatozoa: fertilizing capacity and contribution to the embryo. Int J Androl 34: 513–527

    Article  PubMed  CAS  Google Scholar 

  • Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB (2011) The CatSper channel mediates progesteroneinduced Ca2 +influx in human sperm. Nature 471: 382–386

    Article  PubMed  CAS  Google Scholar 

  • Stuhrmann M, Dörk T (2000) CFTR gene mutations and male infertility. Andrologia 32: 71–83

    Article  PubMed  CAS  Google Scholar 

  • Terquem A, Dadoune JP (1983) Aniline blue staining of human spermatozoon chromatin. Evaluation of nuclear maturation. In: Andre J (ed) The sperm cell. Martinus Nijhoff, The Hague, pp 249–252

    Chapter  Google Scholar 

  • Tiepolo L, Zuffardi O (1976) Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 34: 119–124

    Article  PubMed  CAS  Google Scholar 

  • Tournaye H (2006) Evidence-based management of male subfertility. Curr Opin Obstet Gynecol 18: 253–259

    Article  PubMed  Google Scholar 

  • Tournaye H, Merdad T, Silber S et al. (1999) No differences in outcome after intracytoplasmic sperm injection with fresh or with frozenthawed epididymal spermatozoa. Hum Reprod 14: 90–95

    Article  PubMed  CAS  Google Scholar 

  • Tournaye H, Goossens E, Verheyen G et al. (2004) Preserving the reproductive potential of men and boys with cancer: current concepts and future prospects. Hum Reprod Update 10: 525–532

    Article  PubMed  Google Scholar 

  • Tüttelmann F, Nieschlag E (2009) Nosologie andrologischer Krankheitsbilder. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes, 3. Aufl. Springer, Berlin Heidelberg New York, S 90–96

    Google Scholar 

  • Tüttelmann F, Gromoll J, Kliesch S (2008) Genetik der männlichen Infertilität. Urologe 47: 1561–1567

    Article  PubMed  Google Scholar 

  • Tüttelmann F, Werny F, Cooper TG, Kliesch S, Simoni M, Nieschlag E (2011) Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy. Int J Androl 34: 291–298

    Article  PubMed  Google Scholar 

  • van Casteren NJ, Looijenga LH, Dohle GR (2009) Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. Int J Androl 32: 279–287

    Article  PubMed  CAS  Google Scholar 

  • van Casteren NJ, Boellaard WP, Romijn JC et al. (2010) Gonadal dysfunction in male cancer patients before cytotoxic treatment. Int J Androl 33: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Van Der Steeg JW, Steures P, Eijkemans MJ, F Habbema JD, Hompes PG, Kremer JA, Van Der Leeuw-Harmsen L, Bossuyt PM, Repping S, Silber SJ, Mol BW, Van Der Veen F; Collaborative Effort for Clinical Evaluation in Reproductive Medicine Study Group (2011) Role of semen analysis in subfertile couples. Fertil Steril 95: 1013–1019

    Article  PubMed  Google Scholar 

  • van Voorhis BJ, Barnett M, Sparks AE, Syrop CH, Rosenthal G, Dawson J (2001) Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertil Steril 75: 661–668

    Article  PubMed  CAS  Google Scholar 

  • van Weert JM, Repping S, Van Der Steeg JW, Steures P, Van Der Veen F, Mol BW (2008) A prediction model for ongoing pregnancy after in vitro fertilization in couples with male subfertility. J Reprod Med 53: 250–256

    PubMed  Google Scholar 

  • von Eckardstein S, Simoni M, Bergmann M, Weinbauer GF, Gassner P, Schepers AG, Nieschlag E (1999) Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples. J Clin Endocrinol Metab: 84: 2496–2501

    Article  CAS  Google Scholar 

  • Wagenlehner FME, Naber KG, Bschleipfer T, Brähler E, Weidner W (2009) Prostatitis und männliches Beckenschmerzsyndrom: Diagnostik und Therapie. Dtsch Arztebl Int 106: 175–183

    PubMed  Google Scholar 

  • Walsh TJ, Croughan MS, Schembri M, Chan JM, Turek PJ (2009) Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med 169: 351–356

    Article  PubMed  Google Scholar 

  • Warne DW, Decosterd G, Okada H, Yano Y, Koide N, Howles CM (2009) A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin. Fertil Steril 92: 594–604

    Article  PubMed  CAS  Google Scholar 

  • Weidner W, Pilatz A, Rusz A, Altinkilic B (2011) Neues in der Varikozelen- Therapie bei männlicher Infertilität: Eine Momentaufnahme. Aktuelle Urol 42: 303–5

    Article  PubMed  CAS  Google Scholar 

  • Wikström AM, Raivio T, Hadziselimovic F, Wikström S, Tuuri T, Dunkel L (2004) Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion. J Clin Endocrinol Metab 89: 2263–2270

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization – WHO (1999) WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction, 4th edn. Univ Press, Cambridge

    Google Scholar 

  • World Health Organization – WHO (2010) WHO laboratory manual for the examination and processing of human semen, 5th edn. WHO Press, Geneva, Switzerland

    Google Scholar 

  • Zini A, Sigman M (2009) Are tests of sperm DNA damage clinically useful? J Androl 30: 219–229

    Article  PubMed  CAS  Google Scholar 

  • Zorn B, Virant-Klun I, Meden-Vrtovec H (2000) Semen granulocyte elastase: its relevance for the diagnosis and prognosis of silent genital tract inflammation. Hum Reprod 15: 1978–1984

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gaffky-Straße 14, 35392, Gießen

    Prof. Dr. med. H.-C. Schuppe

  2. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck

    Prof. Dr. med. H.-C. Schuppe

  3. Andrologicum, Burgstraße 7, 80331, München

    Prof. Dr. med. F.-M. Köhn

  4. Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Rudolf-Buchheim-Straße 7, 35392, Gießen

    Prof. Dr. med. W. Weidner

Authors
  1. Prof. Dr. med. H.-C. Schuppe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. med. F.-M. Köhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr. med. W. Weidner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinikum Schleswig-Holstein, Schleswig-Holstein, Campus Lübeck

    Klaus Diedrich  & Georg Griesinger  & 

  2. amedes, Zentrum für Endokrinologie, Kinderwunsch und Pränatale Medizin im Barkhof, Hamburg

    Michael Ludwig

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schuppe, HC., Köhn, FM., Weidner, W. (2013). Andrologie in der interdisziplinären Reproduktionsmedizin. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30181-0_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-30181-0_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-30180-3

  • Online ISBN: 978-3-642-30181-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation