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Trends in Reconstructive Neurosurgery pp 27–36Cite as

Update on Mechanism and Therapeutic Implications of Spinal Cord Stimulation and Cerebral Hemodynamics: A Narrative Review

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 124))

Abstract

Spinal cord stimulation (SCS) is well known for its early role in the management of chronic pain, mainly failed back surgery syndrome (FBSS), spasticity, and bowel and bladder dysfunction. In more recent years, SCS has been proposed for patients suffering from refractory angina or peripheral vasculopathies in order to gain symptom relief, thus indicating some hemodynamic effect on the peripheral circulation. Taking into account this scientific observation, since the late1980s, researchers have started to investigate the potential effect of SCS on cerebral blood flow (CBF) regulation and its possible application in certain pathological settings dealing with vascular pattern dysfunction, such as ischemia, subarachnoid hemorrhage, head trauma, and brain tumors. The aim of this study was to review the scientific literature about SCS and its effect on CBF, evaluating the results both in “physiological” experimental models and clinical studies, as well as in the particular pathological conditions we have mentioned above.

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Conflict of Interest Statement

Conflict of interest statement: the authors declare no conflict of interest and they have not received any financial support in conjunction with the generation of this manuscript

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Authors and Affiliations

  1. Neurosurgery, Catholic University Medical School, Rome, Italy

    Elisabetta Peppucci MD

  2. Institute of Neurosurgery, Catholic University School of Medicine, Largo A. Gemelli 8, Rome, 00168, Italy

    Elisabetta Peppucci MD

  3. Insitute of Neurosurgery, Medical School, Catholic University of Rome, Rome, Italy

    Rina Di Bonaventura MD & Massimiliano Visocchi MD

  4. Università la Sapienza Roma, IRCCS Neuromed Via Atinense 18, Pozzilli (IS), 86077, Italy

    Vincenzo Esposito MD

  5. Department of Neurosurgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China

    Jun Zhong MD, PhD

  6. Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Neurosurgical Clinic, University of Palermo, Palermo, Italy

    Gerardo Iacopino MD

  7. Division of Neurosurgery, Department of Neurosciences, Policlinico “G. Rodolico” University Hospital, Catania, Italy

    Giuseppe Barbagallo MD

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Correspondence to Elisabetta Peppucci MD .

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Editors and Affiliations

  1. Institute of Neurosurgery Medical School, Catholic University of Rome, Rome, Italy

    Massimiliano Visocchi

  2. Dept. of Neurosurgery, Christian-Albrechts-University of Kiel, Kiel, Germany

    H. Maximilian Mehdorn

  3. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Yoichi Katayama

  4. Medical Faculty University of Münster, Münster, Germany

    Klaus R. H. von Wild

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Peppucci, E. et al. (2017). Update on Mechanism and Therapeutic Implications of Spinal Cord Stimulation and Cerebral Hemodynamics: A Narrative Review. In: Visocchi, M., Mehdorn, H.M., Katayama, Y., von Wild, K.R.H. (eds) Trends in Reconstructive Neurosurgery. Acta Neurochirurgica Supplement, vol 124. Springer, Cham. https://doi.org/10.1007/978-3-319-39546-3_5

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