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Endocannabinoids pp 59–93Cite as

Distribution of the Endocannabinoid System in the Central Nervous System

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 231))

Abstract

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degrade endocannabinoids, and the receptors that transduce the effects of endocannabinoids. Much of what we know about the function of endocannabinoids comes from studies that combine localization of endocannabinoid system components with physiological or behavioral approaches. This review will focus on the localization of the best-known components of the endocannabinoid system for which the strongest anatomical evidence exists.

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Abbreviations

2-AG:

2-Arachidonoylglycerol

ABHD4/6/12:

α/β-hydrolase domain 4/6/12

AEA or anandamide:

N-arachidonoylethanolamine

BLA:

Basolateral amygdala

CB1 and CB2 :

Cannabinoid receptor 1 and 2

CRIP1a:

Cannabinoid receptor interacting protein 1a

DAGLα/β:

Diacylglycerol lipase α/β

DRG:

Dorsal root ganglion

FAAH:

Fatty acid amide hydrolase

GDE1:

Glycerophosphodiesterase 1

M1:

Muscarinic cholinergic receptor

MAGL:

Monoacylglycerol lipase

mGluR5:

Metabotropic glutamate receptor 5

MSNs:

Striatal medium spiny neurons

NAAA:

N-acylethanolamine-hydrolyzing acid amidase

NAPE-PLD:

N-acyl phosphatidylethanolamine phospholipase D

PAG:

Periaqueductal gray

SN:

Substantia nigra

TH:

Tyrosine hydroxylase

VTA:

Ventral tegmental area

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Authors and Affiliations

  1. Department of Psychology, National Cheng Kung University, Tainan, 70101, Taiwan

    Sherry Shu-Jung Hu

  2. Department of Psychological and Brain Sciences, Indiana University, 47405, Bloomington, IN, USA

    Ken Mackie

  3. Gill Center for Biomolecular Science, Indiana University, 47405, Bloomington, IN, USA

    Ken Mackie

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  1. Sherry Shu-Jung Hu
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Correspondence to Ken Mackie .

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  1. Professor of Neuropharmacology, University of Aberdeen Institute of Medical Sciences, Aberdeen, United Kingdom

    Roger G. Pertwee

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Hu, S.SJ., Mackie, K. (2015). Distribution of the Endocannabinoid System in the Central Nervous System. In: Pertwee, R. (eds) Endocannabinoids. Handbook of Experimental Pharmacology, vol 231. Springer, Cham. https://doi.org/10.1007/978-3-319-20825-1_3

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